Natural Course of Melanocytic Tumors of the Iris

Territo, Carla; Shields, Carol L.; Shields, Jerry A.; Augsburger, James J.; Schroeder, Robert P.

doi:10.1016/s0161-6420(88)33022-8

Cited by 64 publications

(32 citation statements)

References 9 publications

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“…41,42 Because pigmented iris lesions are more easily observed against a light than dark colored iris, it is likely that this association is partly due to detection bias. Iris melanomas in light-colored eyes progress more rapidly, 43 however, and this may suggest the action of a stimulus to proliferation that also influences their occurrence. 44 Our low numbers of cases of iris and conjunctival melanoma prevented an adequate assessment of their associations with pigmentary characteristics.…”

Section: Discussionmentioning

confidence: 99%

Eye color and cutaneous nevi predict risk of ocular melanoma in Australia

Vajdic¹,

Kricker

Giblin

et al. 2001

Int. J. Cancer

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Ethnicity, cutaneous nevi and eye color are generally accepted risk factors for melanoma of the eye, although casecontrol studies have produced conflicting results. We sought to determine the constitutional risk factors for melanomas of the choroid, ciliary body, iris and conjunctiva in Australia. A population-based case-control study was conducted, with case ascertainment from a prospective national incidence survey and randomly selected community controls. Two hundred and ninety cases aged 18 -79 years and diagnosed between 1st January 1996 and 31st July 1998 were enrolled with 916 controls frequency matched by age, sex and State or Territory of residence. Risk of choroidal and ciliary body melanoma (n ‫؍‬ 246) was increased in people with grey (OR 2.9, 95% CI 1.5-5.5), hazel (OR 2.2, 95% CI 1.4 -3.7) and blue eyes (OR 1.7, 95% CI 1.0 -2.7) compared with brown eyes. Risk was also increased in those with 4 or more nevi on their back, those unable to tan, and those who squinted when outdoors as a child. Risk was reduced in people born other than in Australia and New Zealand (OR 0.7, 95% CI 0.5-1.0). Non-brown eye color was a risk factor for iris melanoma (n ‫؍‬ 25). No risk factors were identified for conjunctival melanoma (n ‫؍‬ 19). Eye color is the strongest constitutional predictor of choroidal and ciliary body melanoma, and may indicate a protective effect of melanin density at these sites. An independent association with cutaneous nevi suggests a role for other genetic factors.

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Section: Discussionmentioning

confidence: 99%

Eye color and cutaneous nevi predict risk of ocular melanoma in Australia

Vajdic¹,

Kricker

Giblin

et al. 2001

Int. J. Cancer

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“…Pupil distortion, ectropion uveae, localised cataract, iridocorneal angle involvement, pigment dispersion, raised intraocular pressure, and spontaneous hyphaema may be found in iris melanomas. 284,330 Diffuse iris melanomas are extremely rare, accounting for 7-10% of all iris melanomas. 330,333 Clinically, diffuse iris melanomas classically present as a patient with unilateral hyperchromatic heterochromia and ipsilateral glaucoma.…”

Section: Eyementioning

confidence: 99%

Don’t it make my blue eyes brown: heterochromia and other abnormalities of the iris

Rennie

2011

Eye

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“…Due to the good prognosis of low malignant iris melanomas in adolescents (Territo et al 1988;Shields et al (2001), we suggest that close follow-up examinations should be scheduled. …”

mentioning

confidence: 87%

“…It is estimated that 4À5% of iris naevi transform into malignant melanomas (Territo et al 1988;Workman & Weiner 1990).…”

mentioning

confidence: 99%