Don’t it make my blue eyes brown: heterochromia and other abnormalities of the iris

Abstract

Eye colour is one of the most important characteristics in determining facial appearance. In this paper I shall discuss the anatomy and genetics of normal eye colour, together with a wide and diverse range of conditions that may produce an alteration in normal iris pigmentation or form.

Genetics of eye colours in different rural populations on the Silk Road

“…1 The iris is a thin diaphragm composed mostly of connective tissue and smooth muscle fibres regulating the amount of light entering the pupil. 2 The colours, texture, and patterns of each person's eyes are unique and are due to different factors, such as the density and structure of the iris stroma, the pigment epithelium, the pigment content within the melanocytes of the iris stroma, and the light-absorption properties of the melanin colouring skin, hair, and eyes.…”

Focal cortical dysplasia and heterochromia of the iris

“…Though HI may occur in healthy individuals as a rare variant,1 in this patient it was likely related to the brain malformation,2 in view of the affected iris of variegated colour being ipsilateral to the somatic findings, and the association with an ipsilateral eighth nerve deficit 3. Neurological conditions associated with HI include Sturge–Weber syndrome, congenital Horner's syndrome and Waardenburg's syndrome 4. Polygenic inheritance of eye colour is suggested, but is incompletely understood,2 4 and the HI seen in our patient suggests that contralateral cerebral hemispheric development may be a determinant of this trait.…”

“…Neurological conditions associated with HI include Sturge–Weber syndrome, congenital Horner's syndrome and Waardenburg's syndrome 4. Polygenic inheritance of eye colour is suggested, but is incompletely understood,2 4 and the HI seen in our patient suggests that contralateral cerebral hemispheric development may be a determinant of this trait.…”

Congenital Heterochromia: A Case Report

“…İris stroması; pupilla dilatör/sfinkter kasları, kan damarları, sinirleri, Adress for correspondence: Uzm.Dr.Rahmi Duman, çamlıtepe mah, Kıbrıs caddesi 9/4, Çankaya, Ankara, Türkiye, 06620 e-mali:drrahmi42@yahoo.com Available at www.actaoncologicaturcica.com Copyright ©Ankara Onkoloji Hastanesi fibroblast, melanosit ve mast hücrelerini içermektedir. Posterior pigment epiteli ise oldukça fazla sayıda hücrelerarası sıkı bağlantı ile birbirlerine bağlı iki sıra küboid pigment hücrelerinden meydana gelmektedir (1).…”

“…Sektöriyel heterokromide iris farklı renkte bölgeler içermekte iken bilateral olarak da görülebilmektedir. Binoküler heterokromide ise etkilenen irisin tamamında renk değişikliği izlenmektedir, diğer gözde her hangi bir patoloji yoktur (1).…”