Focal cortical dysplasia and heterochromia of the iris

Heterochromia iridis: More than beautiful eyes

“…The article on focal cortical dysplasia and heterochromia of the iris in the ‘Images in Medicine’ section reported an association between brain malformation and heterochromia iridis 1 . Although rare, this entity has drawn our attention to the often trivialised heterochromia iridis and its overlooked underlying pathology.…”

“…Besides that, HI can occur following ocular trauma, foreign body, melanocytic infiltration and impaired sympathetic tone 8 . HI associated with large malformation of the cortical development has also been reported 1. Iris colour can be affected by ageing, siderosis, metastatic carcinoma, juvenile xanthogranuloma, acquired Horner syndrome and Fuchs heterochromic iridocyclitis in addition to medication-induced pigmentation, such as by latanoprost, a prostaglandin analogue 9 10 …”