Natural Compounds Derived from Foods Modulate Nitric Oxide Production and Oxidative Status in Epithelial Lung Cells

Zaslaver, Maayan; Offer, Sarit; Kerem, Zohar; Stark, Aliza H.; Weller, J. I.; Eliraz, and Avraham; Madar, Zecharia

doi:10.1021/jf052000u

Cited by 12 publications

(8 citation statements)

References 30 publications

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“…Olive leaf extract. Olive leaf extract was prepared from olive leaves as described by Zaslaver et al 16 Briefly, the leaves were randomly picked from the Barnea cultivar in the Jezreel Valley region of Israel and immediately freeze dried on dry ice. After being thoroughly rinsed with sterile distilled water to remove dust, insecticides, and contaminating material, the olive leaves were ground and Soxhlet extracted with hexane for 3 h followed by 80% aqueous ethanol for 6 h. The alcoholic extract was concentrated under reduced pressure at 25°C, and the powder was encapsulated.…”

Section: Interventionmentioning

confidence: 99%

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

Wainstein

Ganz

Boaz

et al. 2012

Journal of Medicinal Food

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181

142

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Olive tree (Olea europaea L.) leaves have been widely used in traditional remedies in European and Mediterranean countries as extracts, herbal teas, and powder. They contain several potentially bioactive compounds that may have hypoglycemic properties. To examine the efficacy of 500 mg oral olive leaf extract taken once daily in tablet form versus matching placebo in improving glucose homeostasis in adults with type 2 diabetes (T2DM). In this controlled clinical trial, 79 adults with T2DM were randomized to treatment with 500 mg olive leaf extract tablet taken orally once daily or matching placebo. The study duration was 14 weeks. Measures of glucose homeostasis including Hba1c and plasma insulin were measured and compared by treatment assignment. In a series of animal models, normal, streptozotocin (STZ) diabetic, and sand rats were used in the inverted sac model to determine the mechanism through which olive leaf extract affected starch digestion and absorption. In the randomized clinical trial, the subjects treated with olive leaf extract exhibited significantly lower HbA1c and fasting plasma insulin levels; however, postprandial plasma insulin levels did not differ significantly by treatment group. In the animal models, normal and STZ diabetic rats exhibited significantly reduced starch digestion and absorption after treatment with olive leaf extract compared with intestine without olive leaf treatment. Reduced digestion and absorption was observed in both the mucosal and serosal sides of the intestine. Though reduced, the decline in starch digestion and absorption did not reach statistical significance in the sand rats. Olive leaf extract is associated with improved glucose homeostasis in humans. Animal models indicate that this may be facilitated through the reduction of starch digestion and absorption. Olive leaf extract may represent an effective adjunct therapy that normalizes glucose homeostasis in individuals with diabetes.

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Section: Interventionmentioning

confidence: 99%

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

Wainstein

Ganz

Boaz

et al. 2012

Journal of Medicinal Food

Self Cite

181

142

View full text Add to dashboard Cite

show abstract

“…Excess inflammatory mediators (NO and PGE 2 ) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) produced by activated macrophages induce inflammatory process and act synergistically with other inflammatory mediators [2,4,5]. Natural compounds able to inhibit the production of inflammatory mediators or pro-inflammatory cytokines may be attractive as anti-inflammatory agents and, for this reason, the inhibitory effects of phytochemicals on the production of inflammatory mediators or pro-inflammatory cytokines have been intensively studied to develop therapeutic agents for preventing inflammatory diseases [8,11,21]. Recent studies have shown that in vivo or in vitro treatments of natural compounds are effective in reducing inflammation by the suppression of pro-inflammatory cytokines, which may treat inflammation-related diseases, including atherosclerosis, cancer, and inflammatory arthritis [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema

Joung¹,

Lee²,

Choi³

et al. 2012

International Immunopharmacology

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“…Previous studies had verified their effects on regulating cholesterol levels and hypertension, two risk factors commonly associated with heart disease and Alzheimer's disease.the Polyphenols could prevent damage caused by oxidation or neural death in cell cultures [28].…”

Section: D Di Is Sc Cu Us Ss Si Io On Nmentioning

confidence: 99%

Chronic effect of olive oil on some neurotransmitter contents in different brain regions and physiological, histological structure of liver and kidney of male albino rats

Bawazir¹

2011

WJNS

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Olive oil is an important source of mono-unsaturated fat and a prime component of the Mediterranean diet. The beneficial health effects of olive oil are due to both its high content of mono-unsaturated fatty acids and its high content of anti-oxidative substances. The objective of this study was to investigate the basis for the epidemiological information relating to the health benefits associated with the consumption of ex-tra-virgin olive oil (EVOO). The effect of olive oil on norepinephrine (NE), dopamine (DA), serotonin (5-HT) and gamm-aminobutyric acid (GABA) con-tents in different brain regions and histological structure of liver and kindey of male albino rats was studied. The chronic administration of olive oil (7.5 mg/kg body wt.) caused a significant increase in norepinephrine (NE), dopamine (DA) , serotonin (5-HT) and gamm-aminobutyric acid (GABA) con-tent in different brain regions (Cerebellum, striatum, cerebral cortex, hypothalamus, brain steam and hip-pocampus) of male albino rats. The increase in NE, DA, 5-HT, and GABA content in the different CNS areas of male albino rat may be due to the inhibition of Ca2+/calmodulin binding which plays an important role in the release of these neurotransmitters. The results, also, revealed that urea and creatinne con-centrations in rats with oral administration with olive oil were decreased. Meanwhile, the activities of the enzymes AsT, AlT and ALP were elevated. The pre-sent results indicated that there is no change in tis-sues of kidney after treated with virgin olive oil. Olive oil may potentially be safe for use as a sedative drug. improvement also led to the reductions in risk of Alzheimer’s and Parkinson’s diseases

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Natural Compounds Derived from Foods Modulate Nitric Oxide Production and Oxidative Status in Epithelial Lung Cells

Cited by 12 publications

References 30 publications

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats

Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema

Chronic effect of olive oil on some neurotransmitter contents in different brain regions and physiological, histological structure of liver and kidney of male albino rats

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