Natural articular cartilage: A smart biointerface

Pawlak, Zenon; Pai, Raghuvir; Mreła, Aleksandra; Kaczmarek, Mariusz; Yusuf, Kehinde Quasim; Urbaniak, Wiesław

doi:10.3233/jcm-181104

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…A low P v value can easily lead to poor fluid flow in cartilage, but a high P v value can easily lead to cartilage brittleness, resulting in fractures, cartilage loss, and other diseases [ 10 , 11 , 12 ]. For health reasons, the P v values of cartilaginous materials should be as close as possible to that of natural cartilage, which must be between 30% and 47% [ 15 , 16 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…It is worth noting that smaller additions of FANC 12.5 are more favorable for pore formation than a higher addition of FANC 12.5 . In fact, FANC 12.5 easily agglomerates and becomes tangled as FANC 12.5 is added at a higher level (i.e., >3%), which may cause NaCl particles to be wrapped up; thus, more NaCl particles cannot be filtered out by distilled water, resulting in a decrease in porosity [ 37 , 38 ]. The P v of the porous UHMWPE/FANC 12.5 specimens were all above 30% when the addition of NaCl particles exceeded 60% and could reach 38.4% as FANC 12.5 and NaCl particles were added at 3% and 60%, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Fan

Xiuqin

et al. 2021

Materials

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Ultrahigh molecular weight polyethylene (UHMWPE) materials have been prevalent joint replacement materials for more than 45 years because of their excellent biocompatibility and wear resistance. In this study, functionalized activated nanocarbon (FANC) was prepared by grafting maleic anhydride polyethylene onto acid-treated activated nanocarbon. A novel porous UHMWPE composite was prepared by incorporating the appropriate amount of FANC and pore-forming agents during the hot-pressing process for medical UHMWPE powder. The experimental results showed that the best prepared porous UHMWPE/FANC exhibited appropriate tensile strength, porosity, and excellent hydrophilicity, with a contact angle of 65.9°. In vitro experiments showed that the porous UHMWPE/FANC had excellent biocompatibility, which is due to its porous structure and hydrophilicity caused by FANC. This study demonstrates the potential viability for our porous UHMWPE/FANC to be used as cartilage replacement material for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Fan

Xiuqin

et al. 2021

Materials

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“…Each of the many joints that form the human skeleton contributes to the preservation of posture and contributes to the realization of movements of the body and its individual parts in space, however, from a biomechanical point of view, large synovial joints of limbs (primarily the lower ones), among other things, perform bearing functions. It is in them that all the qualities that correspond to the so-called "smart friction units" are most clearly manifested [2,3], but at the same time they are also most often susceptible to diseases and injuries that limit the physical activity of people and in many cases lead to disability.…”

Section: Introductionmentioning

confidence: 99%

Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

2021

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Synovial joints are unique biological tribosystems that allow a person to perform a wide range of movements with minimal energy consumption. In recent years, they have been increasingly called “smart friction units” due to their ability to self-repair and adapt to changing operating conditions. However, in reality, the elements of the internal structure of the joints under the influence of many factors can degrade rather quickly, leading to serious disease such as osteoarthritis. According to the World Health Organization, osteoarthritis is already one of the 10 most disabling diseases in developed countries. In this regard, at present, fundamental research on synovial joints remains highly relevant. Despite the fact that the synovial joints have already been studied fully, many issues related to their operating, prevention, development of pathology, diagnosis and treatment require more detailed consideration. In this article, we discuss the urgent problems that need to be solved for the development of new pharmacological agents, biomaterials, scaffolds, implants and rehabilitation devices for the prevention, rehabilitation and improvement of the treatment effectiveness of synovial joints at various stages of osteoarthritis.

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Natural articular cartilage: A smart biointerface

Cited by 2 publications

References 28 publications

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

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