Natural and Nanotechnology Based Treatment: An Alternative Approach to Psoriasis

Yadav, Nishu; Aggarwal, Remica; Targhotra, Monika; Sahoo, Prabhat K.; Chauhan, Meenakshi Kanwar

doi:10.2174/2468187310999201022192318

Cited by 8 publications

(5 citation statements)

References 149 publications

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“…In addition, the persistence of a dose may cause skin irritation and other negative effects. Topical drug delivery technologies have been investigated for the delivery of therapies to get around these restrictions [ 104 , 105 , 106 ]. The urgent need for novel treatments is also brought by the notion that the scope and application have several negative adverse effects, such as skin shrinkage, susceptibility to sunlight, itchy skin, increased cancer risk, malignancy, inflammatory diseases, and medical complications [ 107 , 108 , 109 ].…”

Section: Biosafetymentioning

confidence: 99%

Pathology and Treatment of Psoriasis Using Nanoformulations

Thirumal,

Sindhu,

Goyal

et al. 2023

Biomedicines

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Psoriasis (PSO) is an inflammatory skin condition that causes a variety of diseases and significantly decreases the life characteristics of patients, and substantially diminishes patients’ quality of life. PSO usually impairs the skin and is linked to various disorders. Inflammation pathology does not only damage psoriatic skin; it shows how PSO impinges other body parts. Many variables interact with one another and can impact the etiology of psoriasis directly or indirectly. PSO has an effect on approximately 2% of the world’s population, and significant progress has been made in comprehending and treating the alternative PSO by novel drug delivery systems. Topical, systemic, biological, biomaterials, and phototherapy are some of the useful therapies for PSO. Nonetheless, topical treatments remain the gold standard for treating moderate PSO. The applicability of several nanocarrier systems, such as lipid nanoparticles, metallic nanoparticles, and certain phytocompounds, has been briefly explored. The present review focuses mainly on traditional therapeutic strategies as well as on breakthroughs in nanoformulations and drug delivery methods for several anti-psoriatic drugs.

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Section: Biosafetymentioning

confidence: 99%

Pathology and Treatment of Psoriasis Using Nanoformulations

Thirumal,

Sindhu,

Goyal

et al. 2023

Biomedicines

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“…Ethanol also facilitates effortless permeation and ensures maximum drug delivery as it generates flexible or easily deformable vesicles (transferosomes) due to its action on phospholipid bilayer to form a channel by disrupting lipid membrane 14 . Ethosomes release entrapped drug for extended period of time while shielding it from degradation and act as drug depot 15 . In skin care products, ethosomes were mostly used to encapsulate antioxidants, vitamins (e.g., retinol and tocopherol), and other active substances.…”

Section: Introductionmentioning

confidence: 99%

“…14 Ethosomes release entrapped drug for extended period of time while shielding it from degradation and act as drug depot. 15 In skin care products, ethosomes were mostly used to encapsulate antioxidants, vitamins (e.g., retinol and tocopherol), and other active substances. They are available in the form of dispersion in creams, serums, and gels.…”

mentioning

confidence: 99%

Development of stable tocopherol succinate‐loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations

Akhtar

2022

J of Cosmetic Dermatology

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Background Tocopherol succinate (TS) represents synthetic derivative of α‐tocopherol (vitamin E), it act as anti‐aging, moisturizing, and antioxidant. Ultraviolet (UV) photo stability of TS is low, and it cause skin irritation. Aim To develop tocopherol succinate loaded ethosomal gel for topical TS delivery and to evaluate its moisturizing and anti‐aging effects. Method Cold method technique was used to produce ethosomal formulations (N = 9) by varying ethanol and lipid concentrations (F1–F9). The most optimized formulation (F5) was selected for further study on the basis of characterization. F5 Formulation was incorporated into gel. Ex vivo permeation study was done by using Franz diffusion cell. Non‐invasive in vivo study was performed using corneometer for the evaluation of skin moisture content and skin mechanical properties by using cutometer, for 12 weeks on human subjects (N = 13). Results Particle size (PS), zeta potential (ZP) and polydispersity index (PDI), Entrapment efficiency were found to be 179.1 nm, −13.7 mV and 0.345, and 99.71%, respectively. Transmission electron microscopy (TEM) depicted spherical ethosomal particles. Ethosomal gel and control gel were evaluated for conductivity and pH. Rheological analysis revealed a non‐Newtonian flow. The release profile showed initial burst and then, sustained release, release data followed Korsmeyer–Peppas model. TS‐loaded ethosomal gel appeared physically stable and showed significant results in terms of skin capacitance and mechanical properties. Conclusion The prepared ethosomal gel formulation containing TS is more stable with enhanced antioxidant, moisturizing properties, and increased TS deposition into the skin layer.

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“…This novel method efficiently ensures the site-specific administration of medications throughout the skin to treat psoriatic lesions. Nanotechnology is one of the most promising technologies with various possibilities and great potential to contribute to innovative option treatments [8][9][10]. The present manuscript aims to discuss the chemistry and pharmacology of calcipotriene, conventional pharmacotherapy and contemporary research on calcipotriene, and its combinations used as nanomedicines for the better management of psoriasis.…”

Section: Introductionmentioning

confidence: 99%