“…In fact, due to intermolecular exchange of some hydrogens of the carbohydrate skeleton with the aqueous medium at several steps of the bioconversion (4-6), many factors are likely to exert an influence on the relative percentages of intra-and intermolecular transfers and on the related kinetic isotope effects. In a previous paper we have examined the role of the nature of the yeast and of the initial concentration of sugars (7). We have shown that, provided that the yield of the bioconversion is sufficiently high, different yeast species lead to very close values of the isotopic ratio of the methyl site of ethanol, (D/H) I .…”