Natriuretic peptides in fish physiology

Loretz, Christopher A.; Pollina, Catherine M.

doi:10.1016/s1095-6433(99)00178-6

Cited by 92 publications

(49 citation statements)

References 90 publications

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“…It is evident that ANP is a hormone intimately involved in blood volume regulation in mammals (51). ANP is secreted in response to an increase in blood volume (atrial stretch) (70), and released ANP restores blood volume to normal by decreasing the uptake and increasing the excretion of both water and Na ϩ .…”

Section: Anp Is a Volume-regulating Hormone In Mammalsmentioning

confidence: 99%

“…There are several studies on the osmoregulatory actions of ANP in teleost species other than eels, the results of which are not always consistent with those of eels, as summarized in a number of reviews (23,26,51,86). Plasma ANP concentration is generally higher in SW fish than in FW fish or in euryhaline fish that are in SW than in FW (25,31,77,105).…”

Section: Osmoregulatory Actions Of Anp In Fish Other Than Eelsmentioning

confidence: 99%

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The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Takei

Hirose

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Takei, Yoshio, and Shigehisa Hirose. The natriuretic peptide system in eels: a key endocrine system for euryhalinity? Am J Physiol Regulatory Integrative Comp Physiol 282: R940-R951, 2002; 10.1152/ajpregu. 00389.2001.-The natriuretic peptide system of a euryhaline teleost, the Japanese eel (Anguilla japonica), consists of three types of hormones [atrial natriuretic peptide (ANP), ventricular natriuretic peptide (VNP), and Ctype natriuretic peptide (CNP)] and four types of receptors [natriuretic peptide receptors (NPR)-A, -B, -C, and -D]. Although ANP is recognized as a volume-regulating hormone that extrudes both Na ϩ and water in mammals, ANP more specifically extrudes Na ϩ in eels. Accumulating evidence shows that ANP is secreted in response to hypernatremia and acts to inhibit the uptake and to stimulate the excretion of Na ϩ but not water, thereby promoting seawater (SW) adaptation. In fact, ANP is secreted immediately after transfer of eels to SW and ameliorates sudden increases in plasma Na ϩ concentration through inhibition of drinking and intestinal absorption of NaCl. ANP also stimulates the secretion of cortisol, a long-acting hormone for SW adaptation, whereas ANP itself disappears quickly from the circulation. Thus ANP is a primary hormone responsible for the initial phase of SW adaptation. By contrast, CNP appears to be a hormone involved in freshwater (FW) adaptation. Recent data show that the gene expression of CNP and its specific receptor, NPR-B, is much enhanced in FW eels. In fact, CNP infusion increases 22 Na uptake from the environment in FW eels. These results show that ANP and CNP, despite high sequence identity, have opposite effects on salinity adaptation in eels. This difference apparently originates from the difference in their specific receptors, ANP for NPR-A and CNP for NPR-B. VNP may compensate the effects of ANP and CNP for adaptation to respective media, because it has high affinity to both receptors. On the basis of these data, the authors suggest that the natriuretic peptide system is a key endocrine system that allows this euryhaline fish to adapt to diverse osmotic environments, particularly in the initial phase of adaptation. atrial natriuretic peptide; ventricular natriuretic peptide; C-type natriuretic peptide; membrane guanylyl cyclase; water and electrolyte balance; molecular evolution; functional evolution; volume regulation; sodium regulation; Anguilla japonica ATRIAL NATRIURETIC PEPTIDE (ANP) was the first member of the natriuretic peptide (NP) family identified in mammals (17,63,69,86). Subsequent to the isolation and sequencing of ANP from the rat atria in 1983, brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were isolated from the porcine brain in 1988 and 1990, respectively, and they were identified as members of the NP family (Fig. 1). Whereas ANP and BNP are circulating hormones secreted from the heart, CNP is principally a paracrine factor in the brain and periphery (71). The basic structure of the NP peptides consists of an intramolecular...

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Section: Anp Is a Volume-regulating Hormone In Mammalsmentioning

confidence: 99%

Section: Osmoregulatory Actions Of Anp In Fish Other Than Eelsmentioning

confidence: 99%

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Takei

Hirose

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Of the studies that do exist on the neuropeptides of fish hearts, the majority have focused on ANP (Donald et al 1992, Loretz & Pollina 2000. In the current study, an ANP-like substance was found in the nerve fibres and nerve cell bodies of the powan hearts.…”

Section: Resultsmentioning

confidence: 47%

“…In the current study, an ANP-like substance was found in the nerve fibres and nerve cell bodies of the powan hearts. The natriuretic peptide system plays a pivotal role in cardiovascular and body fluid homeostasis (Takey 1999), and both hypernatremia (high amounts of sodium in the blood) and hypervolemia (an increase in the volume of circulating blood) in teleosts have been shown to be effective stimuli for the cardiac secretion of natriuretic peptides such as ANP (Loretz & Pollina 2000).…”

Section: Resultsmentioning

confidence: 99%

Histopathology, ultrastructure and immunohistochemistry of Coregonus lavaretus hearts naturally infected with Ichthyocotylurus erraticus (Trematoda)

Dezfuli¹,

Giari²,

Simoni³

et al. 2005

Dis. Aquat. Org.

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Histopathological, ultrastructural and immunohistochemical investigations were conducted on 26 specimens of powan Coregonus lavaretus (L.) from Loch Lomond (Scotland). The hearts of all 26 powan (15 females and 11 males) investigated harboured metacercariae of the digenean trematode Ichthyocotylurus erraticus (Rudolphi, 1809). The vast majority of metacercariae were located either singly or as an aggregation of white cysts on the surface of the bulbus arteriosus. The intensity of infection ranged from 2 to 200 larvae heart -1 , although the number of metacercariae found on male powan did not exceed 13. Histochemically, the parasite cyst wall gave a strong positive reaction with periodic acid schiff (PAS) and a faint positive signal with Azan-Mallory stain. All the metacercariae cysts were embedded in a granulomatous proliferation of heart epicardium tissue, forming a reactive fibroconnective capsule around the parasite. The capsule enclosing the parasite (produced by the host's reaction to the parasite) measured 13.57 to 90.20 µm (37.43 ± 3.56) in thickness. Within the capsule wall, eosinophilic granular cells (EGCs), granulocytes, melanocytes and, in some instances, partially degenerated or vacuolated epithelioid cells were observed in close proximity to the cyst wall. Pigment-bearing macrophages were scattered throughout the granulomatous host-tissue reaction and as macrophage aggregates (MAs) within the capsules surrounding parasites. Immunohistochemical tests were applied to infected heart sections using 12 different antisera. Nerve fibres immunoreactive to bombesin, substance P (SP), and atrial natriuretic peptide (ANP) antisera were observed in close proximity to the parasite larvae. The presence of a serotonin-like substance was also observed within host immune-cells surrounding trematode cysts. Large cells of the epicardium were found to be immunoreactive to met-enkephalin and vasoactive intestinal peptide (VIP) antisera but not immunoreactive to anti-protein gene-product 9.5 (PGP9.5) sera. KEY WORDS: Trematode infection · Immunohistochemistry · Neuromodulators · Heart · Coregonus lavaretusResale or republication not permitted without written consent of the publisher

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“…Natriuretic peptides (NPs) are a hormone family that plays a pivotal role in cardiovascular and body fluid homeostasis in vertebrates (Brenner et al 1990, Evans 1990, Farrell & Olson 2000, Loretz & Pollina 2000, Takei 2000. While the NP family consists of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) in mammals and amphibians, ANP, VNP (ventricular natriuretic peptide) and CNP occur in teleost fish.…”

Section: Introductionmentioning

confidence: 99%

A single and novel natriuretic peptide is expressed in the heart and brain of the most primitive vertebrate, the hagfish (Eptatretus burgeri)

Kawakoshi

Hyodo²,

Yasuda³

et al. 2003

Journal of Molecular Endocrinology

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In teleost fish and tetrapods, the natriuretic peptide (NP) family consists of ANP (atrial natriuretic peptide), BNP (brain natriuretic peptide) and VNP (ventricular natriuretic peptide) that are secreted from the heart, and C-type natriuretic peptide (CNP) that is found in the brain. However, CNP is the only NP identified in the heart and brain of elasmobranchs, suggesting that it is the ancestral type of the NP family and that ANP, BNP and VNP appeared later in the vertebrate phylogeny. To delineate more clearly the molecular evolution of this hormone family, we determined the sequence of NP molecule(s) in evolutionarily the oldest vertebrate group, the cyclostomes. We have cloned a novel NP cDNA from the heart and brain of hagfish, Eptatretus burgeri, using the RACE method and degenerate primers that amplify all known types of NP cDNAs. The novel NP, named EbuNP after the scientific name of this hagfish, appears to be the only NP in the heart and brain, as no other NP cDNAs were amplified even after specific removal of the cloned EbuNP mRNA from the mRNA pool, except for a minor alternatively spliced EbuNP cDNA with a truncated 3′-untranslated sequence. The EbuNP was equally similar to known NPs but was not considered to be a CNP because of the presence of a C-terminal tail sequence. The EbuNP gene was abundantly expressed in the cardiac atrium, ventricle, portal heart and brain but scarcely in the intestine; no expression was observed in the gill and kidney. Mass spectrometry of affinity-purified EbuNP in plasma, heart and brain revealed a 68 amino acid peptide circulating in the blood and stored in the heart, which is cleaved at the typical cleavage signal of a processing enzyme, furin, as observed in mammalian BNP. The C-terminal Gly residue was used for amidation as is the case in eel ANP. The immunoreactive EbuNP was not detected in the brain, suggesting the presence of a different processing form in the brain. These results show that the molecular evolution of the NP family in vertebrates is more complex than previously thought.

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Natriuretic peptides in fish physiology

Cited by 92 publications

References 90 publications

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Histopathology, ultrastructure and immunohistochemistry of Coregonus lavaretus hearts naturally infected with Ichthyocotylurus erraticus (Trematoda)

A single and novel natriuretic peptide is expressed in the heart and brain of the most primitive vertebrate, the hagfish (Eptatretus burgeri)

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