Natriuretic Peptides: Biochemistry, Physiology, Clinical Implication

Kozlov, I. A.; Харламова, И. Е.

doi:10.15360/1813-9779-2009-1-89

Cited by 12 publications

(6 citation statements)

References 80 publications

(142 reference statements)

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“…НУП обладают сходной биохимической структурой, включающей кольцеобразное аминокислотное ядро, N-аминный и C-карбоксильный концевые фрагменты, что позволяет объединить их в одну группу [12,14] (табл. 1).…”

Section: натрийуретические пептидыunclassified

“…N-terminal pro-B-type natriuretic peptide, или NT-proBNP -N-концевой-проМНУП) биологически инертны и имеют диагностическое значение. С-концевые фрагменты обладают активностью и являются гормонами -ПНУП (ANP) и МНУП (BNP) [12,14].…”

Section: натрийуретические пептидыunclassified

“…Основные физиологические эффекты НУП представлены ниже [12,14,[19][20][21] НУП обладают как рядом преимуществ (простота и доступность исследования, высокая прогностическая значимость), так и недостатков (широкая вариабельность значений, обусловленная зависимостью от пола, возраста и сопутствующей патологии) (табл. 2).…”

Section: натрийуретические пептидыunclassified

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The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

Ларина

Лунев

2021

Arhivʺ vnutrennej mediciny

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The search for reliable algorithms for diagnosing heart failure with preserved left ventricular ejection fraction (LVEF) in elderly patients is an urgent problem due to the low specificity of clinical manifestations and the peculiarities of involutive processes occurring in the human body. As an alternative diagnostic approach, it is possible to determine in the blood laboratory biochemical markers — a promising method of diagnosis, prognosis and control of the effectiveness of treatment. The article examines the significance of myocardial stress markers (brain natriuretic peptide, N-terminal brain natriuretic peptide, median fragment of atrial natriuretic peptide); «mechanical» myocardial stress (soluble stimulating growth factor expressed by gene 2 — sST2), copeptin, galectin-3 in patients with heart failure and preserved LVEF, including older persons, as well as the possibility of their use in outpatient practice to predict the course of heart failure. The contribution of the multimarker model for a comprehensive assessment of prognosis is discussed, taking into account both the «hemodynamic» side of myocardial stress (pressure or volume overload, markers — natriuretic peptides), and «mechanical» (fibrosis / hypertrophy / heart remodeling, marker — sST2) myocardial changes.

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Section: натрийуретические пептидыunclassified

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The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

Ларина

Лунев

2021

Arhivʺ vnutrennej mediciny

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“…Увеличение секреции натрийуретических пептидов клетками предсердий и желудочков является ответом на перегрузку сердца объемом или давлением [21]. Основ ные эффекты натрийуретических пептидов связаны с подавлением ренин-ангиотензин-альдостероновой и симпатической нервной системы и проявляются расширением сосудов, снижением уровня вазопрессина и стимулированием натрийуреза и диуреза [22].…”

Section: физиология и патофизиология натрийуретических пептидовunclassified

The Role of Natriuretic Peptides in Management of Premature Infants with Hemodynamically Significant Patent Arterial Duct

Furman

Биянов

Porodikov

et al. 2019

Vopr. sovr. pediatr.

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Hemodynamically significant patent arterial duct in premature infants can be the reason of life-threatening complications. Thus it is topical to define the high risk of such complications and mortality in early neonatal period. We have reviewed researches results covering prognostic value of natriuretic peptides level in premature infants with hemodynamically significant patent arterial duct. The data on management planning of such patients according to the A-type and B-type natriuretic peptides levels is presented.

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“…COPD among the patients with ICMP apparently contributes to increased hypoxemia, oxidative stress and cytokine imbalance, which has an additional negative impact on the state of cardiomyocytes among the patients with ICMP. In addition, COPD leads to more pronounced structural changes in the heart (hypertrophy and dilatation of the right heart, development of pulmonary hypertension), which increases the mechanical stretching of cardiomyocytes and increases the expression of NT-proBNP [7,8,9]. The detected high levels of NT-proBNP in the ICMP group are explained by pronounced structural and functional dysfunction of the left ventricle with ICMP, since this peptide is known to be secreted by The revealed change in the MR-proADM level with ICMP is consistent with the data of other researchers, indicating its increase in various forms of IHD.…”

Section: Table 2 Nt-probnp and Mr-proadm Levels In The Studied Groupmentioning

confidence: 99%

The Effect of Associated Chronic Obstructive Pulmonary Disease on Theindicators of Precursor Oftype B Naturauretic Peptide and Proadrenomedullin Among Patientswith Ischemic Ca

Myasoedova¹,

Воронина²,

Попов³

et al. 2019

AREM

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The study showed that a statistically significant increase of NT-proBNP levels (779,36 [473; 2193] pg/ml) and MR-proADM (1,72 [1,56; 1,98] nmol/l) relative to the control values (69.90 [48.96; 91.00] pg / ml and 0,49 [0,18; 0,58] nmol/l, respectively) is common for the patients with ischemic cardiomyopathy. The presence of concomitant chronic obstructive pulmonary disease among the patients is associated with more pronounced increase in the level of NT-proBNP (872,37 [510; 2355] pg/ml) and MR-proADM (1,97 [1,75; 2,19] nmol/l) compared with a group of patients with isolated ischemic cardiomyopathy. This can be considered as one of the compensation links for this comorbid combination

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Natriuretic Peptides: Biochemistry, Physiology, Clinical Implication

Cited by 12 publications

References 80 publications

The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

The Role of Natriuretic Peptides in Management of Premature Infants with Hemodynamically Significant Patent Arterial Duct

The Effect of Associated Chronic Obstructive Pulmonary Disease on Theindicators of Precursor Oftype B Naturauretic Peptide and Proadrenomedullin Among Patientswith Ischemic Ca

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