The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

Ларина, В. Н.; Лунев, В. И.

doi:10.20514/2226-6704-2021-11-2-98-110

Cited by 5 publications

(1 citation statement)

References 45 publications

(59 reference statements)

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“…Так, отечественные авторы обнаружили максимальный риск смерти от сердечно-сосудистых осложнений и повторной декомпенсации сердечной недостаточности в течение года у пациентов, с концентрацией NT-proBNP при выписке из стационара ≥1696 пг/мл [2]. Однако стоит заметить, что биомаркер, отражая реакцию организма на «гемодинамический» (перегрузка давлением или объемом) миокардиальный стресс, может повышаться и по внекардиальным причинам, включая ХБП [16].…”

Section: Discussionunclassified

Biomarkers in predicting mortality from cardiovascular events in patients with heart failure and an implanted cardioverter-defibrillator

Ilov,

Petrova,

Tverdokhlebova

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study the role of blood biomarkers in predicting death from cardiovascular events in patients with heart failure with reduced ejection fraction (HFrEF) within one year after cardioverter defibrillator (ICD) implantation.Material and methods. This one-center observation study included 384 HFrEF patients (men, 84%, NYHA class III – 74%, NYHA class IV – 7%), who underwent prospective observation for 1 year after ICD implantation. The study of the original panel of modern biomarkers (blood electrolytes, C-reactive protein, creatinine, soluble growth stimulation expressed gene 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), galectin-3), allowing to evaluate HF pathogenesis was conducted. Based on the blood creatinine concentration, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was used to estimate the glomerular filtration rate (GFR).Results. In a one-year observation, the primary endpoint was recorded in 35 patients (11%). Single-factor logistic regression showed 3 biomarkers with the greatest predictive potential (p<0,01), related to the occurrence of the investigated endpoint. The concentration of potassium and NT-proBNP, the GFR (CKD-EPI) was included in the multi-factor predictive model with diagnostic efficiency of 68% (sensitivity of 60%, specificity 71%). It was shown that the cardiovascular death risk increased by 2,64 (OR=2,64; 95% CI: 1,28-5,46; p=0,007) at GFR <60 ml/min/1,73 m2 and increased by 3,32 (OR=3,32; 95% CI: 1,26-8,73; p=0,012) at NT-proBNP >2000 pg/ml.Conclusion. The study of blood biomarkers is promising and in demand for the prediction of adverse outcomes of HF. According to the data obtained, the factors «GFR <60 ml/min/1,73 m2» and «NT-proBNP >2000 pg/ml» may be relevant for one-year mortality prediction.

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Section: Discussionunclassified

Biomarkers in predicting mortality from cardiovascular events in patients with heart failure and an implanted cardioverter-defibrillator

Ilov,

Petrova,

Tverdokhlebova

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Prognostic significance of atrial natriuretic peptide in patients undergoing cardiac surgery

Akselrod,

Gubko,

Dymova

et al. 2023

Anaes. i reanim.

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The role of mitochondrial DNA in the pathogenesis of cardiovascular diseases

et al. 2022

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Diseases of the cardiovascular system keeps the lead among the main causes of invalidity, disability and mortality ofthe population. There is a steady increase in cardiovascular diseases, that is why the identification of new markers, that would allow calculating the risks of complications and associated pathological conditions, is one of the most important tasks of modern fundamental and applied medicine. The paper presents current information on the relationship between the qualitative and quantitative characteristics of mitochondrial DNA with the risk of organ failure. The reasons for the body's immune response to the mitochondrial DNA presence outside the cell are considered. The question of mitochondrial DNAs role in the pathogenesis of cardiovascular pathology and inflammatory processes is highlighted. Contradictory information about the change in the amount of freely circulating mitochondrial DNA during the development of organ failure was revealed. However, all authors agree that the number of mitochondrial DNA copies indicates disorders associated with the provision of vital functions of cells, organs and tissues. The study shows that the level of freely circulating mitochondrial DNA in blood plasma, which is currently used to predict the development of complications and mortality in a number of different diseases, is a promising nonspecific marker of cytolytic processes. A comprehensive study of cytological, biochemical and molecular biological indicators at various (especially at early) stages of organ failure development, as well as during the cardiovascular diseases establishment, will provide new important information about the cellular mechanisms of disease pathogenesis and will form the basis for the development of early diagnostic markers and new therapeutic schemes.

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The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

Cited by 5 publications

References 45 publications

Biomarkers in predicting mortality from cardiovascular events in patients with heart failure and an implanted cardioverter-defibrillator

Biomarkers in predicting mortality from cardiovascular events in patients with heart failure and an implanted cardioverter-defibrillator

Prognostic significance of atrial natriuretic peptide in patients undergoing cardiac surgery

The role of mitochondrial DNA in the pathogenesis of cardiovascular diseases

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