Native Valve Endocarditis due toRalstonia pickettii: A Case Report and Literature Review

Orme, Joseph; Rivera-Bonilla, Tomas; Loli, Akil; Blattman, Negin N.

doi:10.1155/2015/324675

Cited by 13 publications

(18 citation statements)

References 57 publications

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“…Our patient was treated with ciprofloxacin and trimethoprim-sulfamethoxazole, both considered first-choice antibiotics. This turned out to be the best management of the patient; other treatment recommendations include third-generation cephalosporins or carbapenems, which would probably have not been able to eradicate the infection 11. Despite Ralstonia spp.…”

Section: Discussionmentioning

confidence: 99%

A case of persistent bacteraemia by Ralstonia mannitolilytica and Ralstonia pickettii in an intensive care unit

Basso¹,

Venditti²,

Raponi³

et al. 2019

IDR

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The Ralstonia spp . genus is a group of non-fermentative, Gram-negative bacteria often resistant to many antibiotics, which are emerging as opportunistic pathogens frequently associated with infections in hospital settings. We present herein a case of combined R. pickettii and R. mannitolilytica persisting and relapsing bacteraemia, possibly caused by a septic arterial thrombosis secondary to the rupture of an internal carotid artery aneurysm. Microbiology studies showed that both Ralstonia isolates produced biofilm and carried class D oxacillinase genes. When confronted with infections caused by members of the Ralstonia genus, identification to the species level is crucial for correct clinical management, as the two species show different antibiotic susceptibility patterns.

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Section: Discussionmentioning

confidence: 99%

A case of persistent bacteraemia by Ralstonia mannitolilytica and Ralstonia pickettii in an intensive care unit

Basso¹,

Venditti²,

Raponi³

et al. 2019

IDR

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“…Contaminated solutions including water for injection, saline solutions made with purified water, and sterile drug solutions were regarded as the cause of R. pickettii infections in many of the cases. Major conditions associated with R. pickettii infection are bacteraemia/septicaemia and respiratory infections/pneumonia [41, 43, 44].…”

Section: Main Textmentioning

confidence: 99%

Accurate identification and epidemiological characterization of Burkholderia cepacia complex: an update

Ragupathi

Veeraraghavan

2019

Ann Clin Microbiol Antimicrob

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Bacteria belonging to the Burkholderia cepacia complex (Bcc) are among the most important pathogens isolated from cystic fibrosis (CF) patients and in hospital acquired infections (HAI). Accurate identification of Bcc is questionable by conventional biochemical methods. Clonal typing of Burkholderia is also limited due to the problem with identification. Phenotypic identification methods such as VITEK2, protein signature identification methods like VITEK MS, Bruker Biotyper, and molecular targets such as 16S rRNA, recA, hisA and rpsU were reported with varying level of discrimination to identify Bcc. rpsU and/or 16S rRNA sequencing, VITEK2, VITEK MS and Bruker Biotyper could discriminate between Burkholderia spp. and non-Burkholderia spp. Whereas, Bcc complex level identification can be given by VITEK MS, Bruker Biotyper, and 16S rRNA/rpsU/recA/hisA sequencing. For species level identification within Bcc hisA or recA sequencing are reliable. Identification of Bcc is indispensable in CF patients and HAI to ensure appropriate antimicrobial therapy.

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“…R. pickettii and R. mannitolilytica are not considered primary pathogens and, hence, are not screened in routine monitoring analyses in hospitals (Coenye et al 2002;Orme et al 2015;Waugh et al 2010). Nevertheless, it has been argued that the low frequency of infection episodes attributed to Ralstonia spp.…”

Section: Introductionmentioning

confidence: 99%

Association between gentamicin resistance and stress tolerance in water isolates of Ralstonia pickettii and R. mannitolilytica

2018

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Members of the species Ralstonia pickettii and R. mannitolilytica, although ubiquitous and lacking major virulence factors, have been associated with nosocomial outbreaks. Tolerance to metals, antibiotics, and disinfectants may represent an advantage for their ubiquity and opportunistic pathogenic potential. In this study, we compared five strains that differed on the origin (hospital effluent, tap water, mineral water) and in the susceptibility to aminoglycosides, regarding their tolerance to metals and disinfection. The growth kinetics and biofilm formation capacity were tested in four R. pickettii strains and one R. mannitolilytica at sub-inhibitory concentrations of aminoglycosides or arsenite. The survival to UV radiation, chlorine, or hydrogen peroxide was also compared in aminoglycoside resistant and susceptible strains. Aminoglycoside-resistant strains presented a higher tolerance to arsenite than the susceptible ones and either aminoglycosides or arsenite was observed to stimulate the biofilm formation. Sub-inhibitory concentrations of the aminoglycoside gentamicin or arsenite significantly decreased the growth rate and yield, but only arsenite caused a significant increase of the lag phase. Hydrogen peroxide presented higher disinfection effectiveness against aminoglycoside susceptible than against resistant strains, an effect that was not observed for UV or chlorine. Although this conclusion needs validation based on a larger number of isolates, including clinical, the results suggest that aminoglycoside resistance may be associated with traits that influence Ralstonia spp. fitness in the environment.

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Native Valve Endocarditis due toRalstonia pickettii: A Case Report and Literature Review

Cited by 13 publications

References 57 publications

<p>A case of persistent bacteraemia by <em>Ralstonia mannitolilytica</em> and <em>Ralstonia pickettii</em> in an intensive care unit</p>

<p>A case of persistent bacteraemia by <em>Ralstonia mannitolilytica</em> and <em>Ralstonia pickettii</em> in an intensive care unit</p>

Accurate identification and epidemiological characterization of Burkholderia cepacia complex: an update

Association between gentamicin resistance and stress tolerance in water isolates of Ralstonia pickettii and R. mannitolilytica

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