Nationwide survey of indications for oral antimicrobial prescription for pediatric patients from 2013 to 2016 in Japan

Uda, Kazuhiro; Okubo, Yusuke; Iwamoto, Noriko; Morisaki, Naho; Kasai, Masahi; Horikoshi, Yuho; Miyairi, Isao

doi:10.1016/j.jiac.2019.03.004

Cited by 32 publications

(24 citation statements)

References 23 publications

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“…Our result also suggests that fluoroquinolone resistance can occur based on genetic changes other than QRDR mutations, and it is necessary to clarify the resistance mechanism in the future. In Japan, fluoroquinolones are being overused 20 , and there is a concern regarding the increase of fluoroquinolone-resistant isolates in M. fortuitum . Because M. fortuitum shows induced resistance to macrolides, fluoroquinolones play an important role in the treatment of M. fortuitum infections as an oral antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Nationwide surveillance of antimicrobial susceptibility of 509 rapidly growing mycobacteria strains isolated from clinical specimens in Japan

Kamada

Yoshida

Iguchi

et al. 2021

Sci Rep

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This study aimed to identify effective treatments against rapidly growing mycobacteria (RGM) infections by investigating the minimum inhibitory concentrations (MIC) of 24 antimicrobial agents and their molecular mechanisms of resistance. In total, 509 clinical RGM isolates were identified by analyzing the sequences of three housekeeping genes (hsp65, rpoB, and sodA), and their susceptibilities to 24 antimicrobial agents were tested. We also performed sequencing analysis of antimicrobial resistance genes (rrl, rrs, gyrA, and gyrB). To identify Mycobacteroides abscessus group subspecies, we performed PCR-based typing and determined the sequevar of erm(41). We identified 15 RGM species, most of which were susceptible to amikacin and linezolid. Among these species, arbekacin and sitafloxacin had the lowest MIC among the same class of antimicrobials. The MIC of rifabutin for M. abscessus subsp. abscessus (MAB) was lower than that for M. abscessus subsp. massiliense (MMA). The proportion of MAB isolates with MIC ≤ 2 mg/L for rifabutin was significantly higher than that of MMA [MAB: 50/178 (28.1%) vs. MMA: 23/130 (17.7%); p = 0.041]. In summary, our study revealed the antimicrobial susceptibility profile of 15 RGM species isolated in Japan and indicated that arbekacin, sitafloxacin, and rifabutin may be possible therapeutic options for RGM infections.

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Section: Discussionmentioning

confidence: 99%

Nationwide surveillance of antimicrobial susceptibility of 509 rapidly growing mycobacteria strains isolated from clinical specimens in Japan

Kamada

Yoshida

Iguchi

et al. 2021

Sci Rep

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“…In addition, serious ADRs of grade ≥ 3 could also be improved to mild or moderate ADRs of grade ≤ 2 following these measures. Furthermore, it is essential for doctors to prescribe antibiotics more judiciously because, currently, more antibiotics than necessary are being prescribed for pediatric patients in Japan 27 . www.nature.com/scientificreports/ A previous review discussed how many drugs should be considered polypharmacy in pediatric patients 11 .…”

Section: Discussionmentioning

confidence: 99%

Effects of the number of drugs used on the prevalence of adverse drug reactions in children

Sugioka

Tachi

Mizui

et al. 2020

Sci Rep

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In pediatric individuals, polypharmacy would increase the prevalence of adverse drug reactions (ADRs). However, there is no report on the ADR increase adjusted for the influence of concomitant disease types. We conducted a retrospective study in pediatric patients to determine whether polypharmacy is a risk factor for ADR development, after the adjustment. Patients aged 1–14 years on medication who visited Gifu Municipal Hospital (Gifu, Japan) were included. We evaluated patient characteristics, ADR causality, ADR classification and severity, and ADR-causing drugs. We examined the association between ADR prevalence and number of drugs used. We performed multiple logistic regression analyses to investigate risk factors for ADR development. Of 1330 patients, 3.5% sought medical attention for ADRs. ADR causality was most often assessed as “possible,” with gastrointestinal ADRs being the most common. Grade 1 ADRs were the most and antibiotics were the most common suspected ADR-inducing drug. The multiple logistic regression analysis showed that ≥ 2 or ≥ 4 drug use, neoplasms, mental and behavioral disorders, and circulatory system diseases significantly increased ADR prevalence. Polypharmacy increased the prevalence of ADR resulting in hospital visits in children, after adjusting for the influence of disease types. Therefore, proactive polypharmacy control measures are necessary for children.

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“…35 These findings were consistent with those of our previous studies with respect to overuse and physician preference of broad-spectrum antibiotics in common pediatric infectious diseases. [36][37][38][39] The discontinuation of ineffective, inappropriate, or potentially harmful treatment may be necessary for sustainable medicine. A previous study in the United States based on a large database reported that 60% of adults hospitalized with asthma received antibiotics in the absence of an indication for antibiotics with a wide variation in antibiotic treatment patterns in adults.…”

Section: Discussionmentioning

confidence: 99%

Association between early antibiotic treatment and clinical outcomes in children hospitalized for asthma exacerbation

Okubo

Horimukai

Michihata

et al. 2021

Journal of Allergy and Clinical Immunology

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Nationwide survey of indications for oral antimicrobial prescription for pediatric patients from 2013 to 2016 in Japan

Cited by 32 publications

References 23 publications

Nationwide surveillance of antimicrobial susceptibility of 509 rapidly growing mycobacteria strains isolated from clinical specimens in Japan

Nationwide surveillance of antimicrobial susceptibility of 509 rapidly growing mycobacteria strains isolated from clinical specimens in Japan

Effects of the number of drugs used on the prevalence of adverse drug reactions in children

Association between early antibiotic treatment and clinical outcomes in children hospitalized for asthma exacerbation

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