Effects of the number of drugs used on the prevalence of adverse drug reactions in children

Sugioka, Mayuko; Tachi, Tomoya; Mizui, Toshiyuki; Koyama, Aisa; Murayama, Azusa; Katsuno, Hayato; Matsuyama, Takuya; Aoyama, Satoshi; Osawa, Tomohiro; Noguchi, Yoshihiro; Yasuda, Masahiro; Goto, Chitoshi; Teramachi, Hitomi

doi:10.1038/s41598-020-78358-3

Cited by 19 publications

(12 citation statements)

References 24 publications

(45 reference statements)

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“…The ADR incidence had signi cantly increased more than two times with increasing the number of drugs from 1-5 drugs to six drugs and above. In the previous studies, ADR incidence had a statistically signi cant relationship with the number of drugs used [32,50,51]. Both comorbidities and the number of medications contribute to complexities in patients' condition and are associated with an increased risk for ADR [32].…”

Section: Discussionmentioning

confidence: 92%

Incidence of Adverse Drug Reactions in Two Tertiary Hospitals: A Prospective Observational Study

Khalili¹,

Sharifi²,

Mesgarpour³

et al. 2021

Preprint

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Background: Monitoring and detecting adverse drug reactions (ADRs) in hospitals is crucial to improving drug safety and healthcare delivery quality. Nevertheless, there was not enough information on ADR incidence and its figure in Iran. Aim: this study aimed to determine the incidence of ADRs in hospitalized patients and investigate their characteristics in Iran.Methods: We conducted a three-month prospective study in two tertiary hospitals in 2019. All admitted patients were intensively monitored for all suspected ADRs through daily visiting hospital wards and soliciting information from physicians, nurses and interviewing suspicious patients. We calculated the incidence of ADRs, and 95% confidence intervals (95% CI). Poisson regression was used to evaluate risk factors for ADR incidence. Results: Among 13,613 admitted patients, we detected 115 ADRs in 114 patients. The incidence of ADR was 8.4 per 1000 admissions (95% CI: 7.0-10.1), and 13.9% of them were ADR-related hospital admissions. The risk of ADRs was significantly predicted by age, length of hospital stay, patients’ diagnostics, number of drug usage, and using respiratory system agents and anti-infectives for systemic use. The most common ADRs were skin and subcutaneous manifestations (52.2%), and 62.6% of ADRs were caused by anti-infectives (commonly vancomycin, ceftriaxone, and ciprofloxacin). Conclusion: This study indicated that ADRs occurrence during the hospital stay or resulting in hospital admissions are considerable. Given that ADR occurrence could be associated with increased morbidity, mortality, and economic burden, constant intensive monitoring is required to address the drug safety issue and promote actions to improve patient safety and reduce the health and economic burden.

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Section: Discussionmentioning

confidence: 92%

Incidence of Adverse Drug Reactions in Two Tertiary Hospitals: A Prospective Observational Study

Khalili¹,

Sharifi²,

Mesgarpour³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Between 8 and 12% of children and young people are exposed to excessive polypharmacy (≥10 unique medications each year), increasing their risk of adverse effects and drug interactions. 2 The study also provides important insights about which children and young people are most likely to experience polypharmacy. These include children with a main diagnosis of a respiratory, neurological or metabolic life-limiting condition when compared to those with a congenital condition.…”

Section: Discussionmentioning

confidence: 98%

Polypharmacy in Children and Young People With Life-limiting Conditions From 2000 to 2015: A Repeated Cross-sectional Study in England

Fraser¹,

Gibson-Smith²,

Jarvis³

et al. 2022

Journal of Pain and Symptom Management

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“…Polypharmacy is a risk factor for the development of ADR in outpatients and hospitalized patients. 18 It is not realistic to establish the use of two or more drugs as the cut-off point to avoid polypharmacy-inducing adverse drug reactions (ADRs), according to Receiver Operating Curves (ROC). The prevalence of ADR was significantly higher among patients who used 4–5 or 6 drugs rather than just one drug.…”

Section: Discussionmentioning

confidence: 99%

Adverse Drug Reaction and Its Predictors Among Psychiatric Patients Taking Psychotropic Medications at the Mizan-Tepi University Teaching Hospital

Ejeta¹,

Aferu²,

Feyisa³

et al. 2021

NDT

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Introduction Psychotropic medications are crucial in the treatment of a variety of psychiatric disorders. Use of second-generation antipsychotics (SGA) has been associated with many adverse events. Assessment and monitoring of ADRs is required to develop appropriate interventional strategies to manage, prevent and minimize the risks of undesirable effects and thus improve quality of life and adherence, avoid relapse, and reduce treatment costs. Objective The objectives of this study were to assess adverse drug reactions and its predictors in psychiatric patients taking psychotropic medications from the outpatient pharmacy of MTUTH. Methods A cross-sectional study design was conducted using a structured questionnaire interviewing a psychiatric patient. One way ANOVA and bivariate logistic regression was computed for all independent variables to identify variables that fit for multivariate logistic regression. A p-value less than 0.05 was considered significant. Results and Discussions A total of 101 patients (91.8%) experienced one or more types of ADR in the current study. There was a statistically significant relationship between ADRs management and age, marital status, educational status, occupation, and monthly income of the study participants. The odds of having experienced autonomic adverse drug reactions experience among respondents aged 30 years and older higher than those under 30 years. Participants taking multiple medications were more likely to face psychiatric adverse drug reactions compared to those taking a single medication. Patients taking multiple psychotropic medications were ten times more likely to develop autonomic adverse drug reactions compared to those taking a single drug. Conclusion The study revealed a moderate incidence of ADR in patients attending the psychiatric OPD. Age and number of antipsychotics were predictors of ADR (autonomic and psychiatric). This study revealed that there is a gap in the role of clinicians in the monitoring and reporting of ADRs.

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Effects of the number of drugs used on the prevalence of adverse drug reactions in children

Cited by 19 publications

References 24 publications

Incidence of Adverse Drug Reactions in Two Tertiary Hospitals: A Prospective Observational Study

Incidence of Adverse Drug Reactions in Two Tertiary Hospitals: A Prospective Observational Study

Polypharmacy in Children and Young People With Life-limiting Conditions From 2000 to 2015: A Repeated Cross-sectional Study in England

Adverse Drug Reaction and Its Predictors Among Psychiatric Patients Taking Psychotropic Medications at the Mizan-Tepi University Teaching Hospital

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