Nationwide prevalence of inflammatory bowel disease in Sweden: a population-based register study

Büsch, Katharina; Ludvigsson, Jonas F.; Ekström-Smedby, Karin; Ekbom, Anders; Askling, Johan; Neovius, Martin

doi:10.1111/apt.12528

Cited by 121 publications

(104 citation statements)

References 38 publications

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“…In the Western society the prevalence of inflammatory bowel disease is approaching 1% and in Sweden the percentage is around 0.65%. [205]. IBD is divided into ulcerative colitis (UC), Crohn's disease (CD), microscopic colitis (MC) and indeterminate colitis.…”

Section: Inflammatory Bowel Disease and Microscopic Colitismentioning

confidence: 99%

Aquaporins in Infection and Inflammation

Holm¹

2016

Linköping University Medical Dissertations

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About the cover:The front cover displays a human, blood-derived macrophage stained for aquaporin 9.During the course of the research underlying this thesis, Angelika Holm was enrolled in Forum Scientium, a multidisciplinary doctoral programme at Linköping University Printed by LiU-Tryck, Linköping, Sweden, 2016 "Be brave, even if you're not, pretend to be. No one can tell the difference."To that young, awkward, tall girl who dared to dream of something else, something more:You did it. SUPERVISOR Elena VikströmDepartment of Clinical and Experimental Medicine Linköping University Linköping Sweden When cells of the innate immune system encounter pathogens they need to respond and prepare for migration and phagocytosis and do so through volume regulatory processes. The Gramnegative bacterium Pseudomonas aeruginosa utilizes a small molecule-based communication system, called quorum sensing (QS) to control the production of its virulence factors and biofilms. We found that P. aeruginosa with a complete QS system elicits a stronger phagocytic response in human blood-derived macrophages compared to its lasI-/rhlI-mutant lacking the production of the QS molecules N-butyryl-L-homoserine lactone (C4-HSL) and N-3-oxododecanoyl-L-homoserine lactone (3O-C12-HSL). Infection with P. aeruginosa further increases the expression of AQP9 and induces re-localisation of AQP9 to the front and trailing ends of macrophages. Moreover, the 3O-C12-HSL alone elevates the expression of AQP9, redistribute the water channel to the front and rear ends and increases the cell area and volume of macrophages. Both infection with the wild type P. aeruginosa and the treatment with 3O-C12-HSL change the nano-structural architecture of the AQP9 distribution in macrophages. ASSISTANT SUPERVISORS Karl-Eric MagnussonViruses use the intracellular machinery of the invaded cells to produce and assemble new viral bodies. Intracellular AQPs are localised in a membranes of cellular organelles to regulate their function and morphology. C3H10T1/2 fibroblasts transiently expressing green fluorescent protein (GFP)-AQP6 show a reduced expression of AQP6 after Hazara virus infection and an increased cell area. Overexpressing AQP6 in C3H10T1/2 cells reduces the infectivity of Hazara virus indicating that AQP6 expression has a protective role in virus infections.Ion and water channels in the epithelial cell lining tightly regulate the water homeostasis. In microscopic colitis (MC), patients suffer from severe watery diarrhoeas. For the first time, we have shown that the expression of AQP1, 8 and 11 and the sodium/hydrogen exchanger NHE1 are reduced in colonic biopsies from MC patients compared to healthy control individuals. Following treatment with the glucocorticoid budesonide the patients experienced a rapid recovery and we observed a restored or increased expression of the AQPs and NHE1 during treatment, suggesting a role for AQPs in the diarrhoeal mechanisms in MC.Taken together, this thesis provides new evidence on the importance of water homeostasis regulatio...

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Section: Inflammatory Bowel Disease and Microscopic Colitismentioning

confidence: 99%

Aquaporins in Infection and Inflammation

Holm¹

2016

Linköping University Medical Dissertations

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“…This is the first survey in Sweden on treatment with TNF inhibitors in IBD, a country where the prevalence of IBD is approaching 0.7% [1] . Anti-TNF treatment in IBD is constantly evolving and it is now 5 years since the last survey regarding practice patterns of anti-TNF treatment in IBD was conducted in Europe [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Crohn's disease and ulcerative colitis are chronic inflammatory disorders that affect more than 60,000 people in Sweden [1] . Here, anti-TNF-α antibodies have been used in the treatment of Crohn's disease (CD) since 1999 and in recent years also in the treatment of ulcerative colitis (UC).…”

Section: Introductionmentioning

confidence: 99%

Current Practice of Anti-TNF-α Treatment in Inflammatory Bowel Disease: Results From A National Survey in Sweden

Hindorf

Almér

2014

Journal of Gastroenterology and Hepatology Research

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“…Abdulkader Mohammed Albasri regarding IBD, there is abundant scientific material on epidemiology and related parameters from the Western and developed world (Lakatos et al, 2011;Mangat et al, 2011;Achitei et al, 2013;Klarin et al, 2013;Penn et al, 2013;Burisch., 2014;Busch et al, 2014;Golovics et al, 2014, Ko et al, 2014Nguyen et al, 2014;Norgard et al, 2014). Asian scientists have contributed to IBD literature significantly suring the last five years (Ahuja & Tandon, 2010;Al-Jashamy et al, 2010;Ren & Fang, 2011;Ng et al, 2013;Wei et al, 2013;Zeng et al, 2013;Huai et al, 2014;Kasturiratne et al, 2014).…”

Section: Histopathological Profile Of Benign Colorectal Diseases In Amentioning

confidence: 99%

Histopathological Profile of Benign Colorectal Diseases in Al-Madinah Region of Saudi Arabia

Albasri

2014

Asian Pacific Journal of Cancer Prevention

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Nationwide prevalence of inflammatory bowel disease in Sweden: a population-based register study

Abstract: SUMMARY BackgroundRegional studies on inflammatory bowel disease (IBD) suggest an increasing prevalence over time, but no nationwide estimate has been published so far.

Cited by 121 publications

References 38 publications

Aquaporins in Infection and Inflammation

Aquaporins in Infection and Inflammation

Current Practice of Anti-TNF-α Treatment in Inflammatory Bowel Disease: Results From A National Survey in Sweden

Histopathological Profile of Benign Colorectal Diseases in Al-Madinah Region of Saudi Arabia

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