Histopathological Profile of Benign Colorectal Diseases in Al-Madinah Region of Saudi Arabia

Albasri, Abdulkader M.

doi:10.7314/apjcp.2014.15.18.7673

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…On the contrary CD was more common in females than males with a female: male ratio of 1.2:1 and was found in patients between 15 and 40 years of age, with a mean age of 27.1 years. 20 Dysplasia has been widely accepted as a progenitor to CRC in patients with IBD. It is a highly significant determinant of further intervention and management of the disease.…”

Section: Discussionmentioning

confidence: 99%

Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

Almottowa

Alkhars

Hassan

et al. 2022

Int J Community Med Public Health

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Ulcerative colitis (UC) and Crohn’s disease (CD) are two major inflammatory disorders of the intestinal wall collectively known as inflammatory bowel disease (IBD). Colorectal carcinoma (CRC) is the most significant and grave consequence of IBD and is preceded by dysplasia in majority of the cases. In this review we aim to discuss the various types of dysplasia found in patients with CRC due to IBD. A thorough literature search was conducted in online databases such as PubMed, Google Scholar, from which all studies published in the last ten years were included in this review. The major development in diagnostic procedures and visualization modalities have aided our understanding of dysplasia, which is now known to be the strongest predictor and marker for CRC development. However, the unpredictable behavior and progression of dysplasia still warrants vigilant surveillance. Dysplasia has been classified on histological characteristics using grades of dysplasia from ‘negative for dysplasia’ to ‘high grade dysplasia’. On visibility via an endoscope from ‘visible dysplasia’ to ‘invisible dysplasia’ and macroscopic features of ‘conventional dysplasia’ and ‘non-conventional dysplasia’. No single classification can be utilized to define the stage of dysplasia and more importantly predict its progression and outcome of CRC. Using evidence-based medicine an integrated classification expanding on a management algorithm must be formulated by a panel of experts to steer management of the disease. A multidisciplinary, tailored approach with a strong emphasis on regular and timely surveillance to ensure early detection of CRC can enhance quality of life and patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

Almottowa

Alkhars

Hassan

et al. 2022

Int J Community Med Public Health

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“…Of these, sixty patients were female and 75 were male. Table 1 shows the demographic characteristics of patients in different countries that have been studied in the large centers for treatment of gastrointestinal diseases (8)(9)(10)(11)(12). As the table shows, males have been affected more than females, although the difference is not significant.…”

Section: Prevalence and Demographic Findingsmentioning

confidence: 99%

Solitary Rectal Ulcer: A Literature Review

2015

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Context: Solitary rectal ulcer (SRU) is a disease with many challenging issues. There are several controversies about the basic pathophysiology of this disease. Despite its name, "solitary rectal ulcer", more than a quarter of patients do not show any ulcer in colonoscopy. Instead, many patients show multiple polypoid lesions. Some previous reports have suggested calling this disease "rectal mucosal prolapse" instead of SRU, however, most of the patients do not have mucosal prolapse. In addition, colonoscopic findings can be very similar to cancer and inflammatory bowel disease, so without histologic evaluation, accurate diagnosis is not always possible. In patients with SRU, sometimes the rectal mucosa is so fibrotic that mucosal biopsy is inadequate, and even a pathologist cannot diagnose the characteristic histologic findings. There are various therapeutic approaches for the treatment of SRU, both surgical and nonsurgical, all of which are not optimal, and recurrence rates are still high with many patients experiencing complications even after surgery, resection and rectopexy. Evidence Acquisition: Although this disease is not uncommon in Iran, there are very few studies from Iran, therefore, in this review we will describe our experience with patients with SRU in affiliated hospitals of Shiraz University of Medical Sciences. We will also review previously published articles about SRU that are indexed in PubMed and Google scholar, emphasizing the challenging issues. Results: SRU is not an uncommon disease in Iran, however the number of published articles about it, is very low. Multicentric studies are necessary to find out the definite reason of this issue. Conclusions: There are still many conflicting controversies about the etiology, pathogenesis, diagnosis and also treatment of SRU, which need further investigation and longer follow up of the patient in each therapeutic approach to be better understood.

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“…In Saudi Arabia, CRC ranks first in males and third in females [ 3 ]. An increase in the CRC incidence rate for males and females in a study published in 2017 pointed to a continuous increase since 2002, along with a variation in the rates between males and females [ 4 ]. The purpose of this review was to reflect on the current state of CRC screening in Saudi Arabia, using recently published papers concerning CRC, the lack of countrywide policy, participants' awareness, and barriers ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update

Hassan Alqarni,

Alamri,

Pushparaj

et al. 2024

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Colorectal cancer (CRC) is the second most common cancer in the world. In Saudi Arabia, CRC is the most common cancer in males and the third most common in females, and its incidence rate is rising as the country continues to develop. However, the country does not have a national CRC screening program for CRC. This review aims to review recent studies that have attempted to address and rectify this issue and discern the most notable and prevalent barriers. Despite these efforts, guidelines are still lacking. Two prospective studies have been conducted in recent years, one of which was a national pilot screening program conducted by the Ministry of Health (MOH). While both had a similar number of participants, the colonoscopy rate for patients with a positive fecal immunochemical test (FIT) in the MOH program was only 20% compared to 75.8% in the Al-Kharj program. Awareness of the Saudi population regarding CRC and its screening appears to be insufficient. The most common barriers to patients' willingness to undergo screening were embarrassment, fear, and pain. Barriers to physicians are mostly related to factors outside their hands, such as lack of equipment and time. We conclude that efforts should be made to establish a national screening program and improve awareness of the population and physicians.

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Histopathological Profile of Benign Colorectal Diseases in Al-Madinah Region of Saudi Arabia

Cited by 8 publications

References 32 publications

Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

Types of colorectal cancer and dysplasia associated with inflammatory bowel disease

Solitary Rectal Ulcer: A Literature Review

Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update

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