National Seroprevalence of Toxoplasma gondii in India

Dhumne, M.; Sengupta, C.; Kadival, G V; Rathinaswamy, A.; Velumani, A.

doi:10.1645/ge-1159.1

Cited by 50 publications

(35 citation statements)

References 8 publications

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“…In addition, the age in which seroconversion and parasitemia takes place might also play a role. Seroprevalence for T. gondii in Thailand was 17 % [17], comparable to China (14.8 %) [18] and India (24 %) [19], but lower than in Indonesia (58-70 %) [20,21] and higher than in Vietnam (4.2 %) [22]. When compared to the West, seroprevalence for T. gondii in Thailand was lower than in the Netherlands (41 %) and France (75 %), but similar to the US (14-22.5 %) where T. gondii infections represent the most common cause of intraocular infections in PU [1,23].…”

Section: Discussionmentioning

confidence: 83%

Infectious causes of posterior uveitis and panuveitis in Thailand

et al. 2012

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Section: Discussionmentioning

confidence: 83%

Infectious causes of posterior uveitis and panuveitis in Thailand

et al. 2012

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“…The organism is zoonotically important and up to one-third of the human population in the world is chronically infected (Dubey and Beattie 1988;Tenter et al 2000). A recent national survey revealed that 24.3% of Indian population is exposed to this parasite (Dhumne et al 2007). Postnatal infection in humans occurs through ingestion of undercooked meat containing tissue cysts or through consumption of food or water contaminated with oocysts (Dubey and Beattie 1988;Dubey et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Genetic characterization of Toxoplasma gondii isolates from chickens in India by GRA6 gene sequence analysis

Biradar¹,

Saravanan

Tewari

et al. 2014

Acta Parasitologica

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PCR-RFLP and nucleotide sequencing based genotyping of Toxoplasma gondii Indian isolates (Izatnagar and Chennai isolates and Chennai clone) vis-a vis RH-IVRI strain was conducted by targeting GRA6 as genetic marker. The 791 bp GRA6 product was PCR amplified from the genomic DNA of different T. gondii Indian isolates, including the RH-IVRI strain. Tru1I restriction endonuclease based PCR-RFLP of GRA6 sequence produced polymorphic digestion pattern that discriminated the virulent RH-IVRI strain (as type I) from the moderately virulent local isolates as type III. The PCR amplicon of T. gondii GRA6 from RH-IVRI strain as well as from the local isolates were cloned in cloning vector and custom sequenced. The nucleotide and deduced amino acid sequences of T. gondii isolates were aligned with that of the type I, II and III strains (RH, BEVER-LEY, ME49, C56, TONT and NED) available in public domain and analyzed in silico using MEGA version 4.0 software. Nucleotide sequencing and phylogenetic analysis of GRA6 marker from the Indian isolates revealed a close genetic relationship with type III strains of T. gondii. Further, detection of a single nucleotide polymorphism (SNP) at positions 162 and 171 of the GRA6 marker, established the lineage of Indian isolates as type III. This is the first report on characterization of T. gondii lineage as type III in selective chicken population of India based on PCR-RFLP and sequence analysis of GRA6 gene.

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“…[6] Seroprevalence average of T. gondii infection in India has been reported to be 24.3%, lowest being in the northern parts of India, and highest in the south and seroconversion rate of 1.5% has been reported. [7] The seroprevalence of toxoplasma in Chandigarh area has been reported to be about 5% with more women showing seropositivity than males. [8] Moreover, since only the acute infection during pregnancy is associated with congenital infections, it is important to know the incidence of acute infection during pregnancy.…”

Section: Introductionmentioning

confidence: 99%