National prevalence of oral HPV infection and related risk factors in the US adult population reply

Sanders, AE; Slade, GD; Patton, Lauren L.

doi:10.1111/j.1601-0825.2012.01954.x

Cited by 12 publications

(11 citation statements)

References 5 publications

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“…Sanders et al showed that 3.7% of Americans had oral HPV, with 1.3% being oncogenic. In this study, education status, smoking, age, sex and number of sexual partners were not associated with HPV infection ( 11 ). Ragin et al evaluated buccal mucosa cells in 118 healthy women without oral lesions and reported a prevalence of 7.1% for oral HPV.…”

Section: Discussionmentioning

confidence: 58%

Detection of Salivary Human Papilloma Viruses 16 and 18 (HPV) in Smoker Men in an Iranian Population by PCR: A Pilot Study

Arbabi-Kalati

Nosratzehi

Bameri

et al. 2014

Int J High Risk Behav Addict

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Background:Human papilloma virus (HPV) infection of the oropharynx is acquired through a variety of sexual and social forms of transmission. Recent epidemiologic evidence has suggested that HPV may be an independent risk factor for oropharyngeal cancers, but risk factors for persistent HPV infection in the oropharynx are unknown. More evidence is needed regarding the prevalence of oral high-risk HPV among healthy smoker and nonsmoker adults.Objectives:The aim of this study was to compare salivary infection with human papilloma virus types 16 and 18 between smokers and nonsmokers.Patients and Methods:A hundred healthy adult subjects were selected from Zahedan dental school for this pilot study. DNA was isolated from saliva samples and screened for high-risk HPV strains of HPV 16 and 18. Then, further processed using Real Time PCR for quantification and confirmation of sensitivity and specificity of the test. Data was analyzed by t-test.Results:There were no high-risk types of virus in patients and no significant differences between the groups (P = 1).Conclusions:It seems that smoking cannot increase the prevalence of high risk HPV 16, 18 in saliva samples.

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Section: Discussionmentioning

confidence: 58%

Detection of Salivary Human Papilloma Viruses 16 and 18 (HPV) in Smoker Men in an Iranian Population by PCR: A Pilot Study

Arbabi-Kalati

Nosratzehi

Bameri

et al. 2014

Int J High Risk Behav Addict

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“…The prevalence of HPV within the oral cavity ranges from 0.9 to 12.0%, 12,23,24 with the prevalence of high-risk types reported to be between 1 and 3%. 17,25 HPV has also been detected in the oral cavity of children younger than age 20 with a prevalence of 1.9 to 6.0%. 23,26 However, most incident and prevalent HPV infections in the mouth are cleared within 1 to 2 years and high viral load predicts persistence of infection.…”

Section: Discussionmentioning

confidence: 99%

HPV-16 in a distinct subset of oral epithelial dysplasia

et al. 2017

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Human papillomavirus (HPV) 16 is the most common high-risk HPV type identified in oropharyngeal and cervical neoplasia. Recently, HPV-associated oral epithelial dysplasia with specific histopathologic features and demographics similar to HPV-oropharyngeal carcinoma has been identified. The objective of this study was to evaluate histopathologically all cases of HPV-oral epithelial dysplasia seen in one center and identify HPV types in a subset of cases. Cases with specific histopathology for HPV-oral epithelial dysplasia that were positive both by immunohistochemical studies for p16 and by in situ hybridization for high-risk types of HPV were further analyzed using QIAamp DNA Tissue Kits (Qiagen, Hilden, Germany). DNA was extracted, amplified, and digested with restriction enzymes and run on a polyacrylamide gel. Digestion patterns were visually compared with a database of known HPV digestion patterns for identification. There were 53 specimens included in the analysis. There were 47 males and six females (7.8:1), with a median age of 55 years (range 41-81). The most common site of involvement was the tongue/floor of mouth (77% of cases). Of the 53 cases, 94% exhibited parakeratosis and/or hyperkeratosis. All the cases featured karyorrhexis, apoptosis, and characteristics of conventional carcinoma in situ. The quantity of DNA extracted was sufficient for analysis in 22 cases. HPV-16 was identified in 20/22 (91%) cases. One case was associated with HPV-33 and one with HPV-58 (5% each). Eight of the 53 cases (15%) were associated with invasive squamous cell carcinomas.

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“…Histological similarities between cervicovaginal and oropharyngeal districts, both coated with squamous or slightly keratinized epithelium (23), and the capacity of the virus to immortalize in vitro human oral keratinocytes, have allowed to transfer the concept of HPV-induced oncogenicity in the gynaecological area, to the oral cavity.…”

Section: Hpv Oral Infection: Oral Manifestationsmentioning

confidence: 99%

“…In the past, due to the clinical presentation (white plaque with irregular surface and verrucous surface) and the first virological studies indicating a high frequency of HPV 16, it was strongly associated with infection, so to be defined as "viroplasia". However, subsequent studies (20,23) provided others results: as the sensitivity and specificity of the diagnostic tests used increase, the frequency of infection rate is reduced or, however, does not increase significantly with respect to OL. The OE is a rare PMOD characterized by a major neoplastic risk.…”

Section: Clinical Infection Benign Lesionsmentioning

confidence: 99%

HPV Infection in the Oral Cavity: Epidemiology, Clinical Manifestations and Relationship With Oral Cancer

Candotto

Lauritano

Nardone

et al. 2017

ORL

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209nomas (OPSCCs) (3, 4). The etiologic role of human papillomavirus infection in the development of Squamous Cell Carcinomas (SCC) of the uterine cervix has been widely demonstrated, so that this tumour is caused, in almost of the cases, by the persistent infectious status by high-risk atypical genotypes. There is also strong evidence to support a causal role of these viruses in the etiopathogenesis of SCC, both in the anogenital area and in the head area (for example, pharynx, larynx and oral cavity) (5). Genital HPV infection is one of SUMMARY Purpose. The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions. Materials and methods. A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Therapeutic protocols are also described where necessary. Results. In recent years there has been a growing interest in HPV oral medicine, suggesting a role of such a family of viruses in the development of neoplasms of the oropharyngeal district as well as of the uterine cervix. Even if the mass media have increasingly faced the problem, causing frequent alarming among patients, the dentist therefore needs a complete and up-to-date knowledge of this infectious condition that is one of the most common causes of sexually transmitted mucous membrane infections (e.g. genital, anal and oral). Conclusions. Recent studies about HPV infection are a basic requirement in order to promote the health of patients and provide them with the most exhaustive indications from dentists.

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National prevalence of oral HPV infection and related risk factors in the US adult population reply

Cited by 12 publications

References 5 publications

Detection of Salivary Human Papilloma Viruses 16 and 18 (HPV) in Smoker Men in an Iranian Population by PCR: A Pilot Study

Detection of Salivary Human Papilloma Viruses 16 and 18 (HPV) in Smoker Men in an Iranian Population by PCR: A Pilot Study

HPV-16 in a distinct subset of oral epithelial dysplasia

HPV Infection in the Oral Cavity: Epidemiology, Clinical Manifestations and Relationship With Oral Cancer

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