HPV Infection in the Oral Cavity: Epidemiology, Clinical Manifestations and Relationship With Oral Cancer

Abstract

209nomas (OPSCCs) (3, 4). The etiologic role of human papillomavirus infection in the development of Squamous Cell Carcinomas (SCC) of the uterine cervix has been widely demonstrated, so that this tumour is caused, in almost of the cases, by the persistent infectious status by high-risk atypical genotypes. There is also strong evidence to support a causal role of these viruses in the etiopathogenesis of SCC, both in the anogenital area and in the head area (for example, pharynx, larynx and oral cavity) (5). Genital HPV infection is one of SUMMARY Purpose. The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions. Materials and methods. A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Therapeutic protocols are also described where necessary. Results. In recent years there has been a growing interest in HPV oral medicine, suggesting a role of such a family of viruses in the development of neoplasms of the oropharyngeal district as well as of the uterine cervix. Even if the mass media have increasingly faced the problem, causing frequent alarming among patients, the dentist therefore needs a complete and up-to-date knowledge of this infectious condition that is one of the most common causes of sexually transmitted mucous membrane infections (e.g. genital, anal and oral). Conclusions. Recent studies about HPV infection are a basic requirement in order to promote the health of patients and provide them with the most exhaustive indications from dentists.

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

“…Most of them exhibited some lesions related to chronic mechanical irritation, and no clinical manifestations suggestive of HPV infection were found in any of the HPV positive subjects [30]. However, oral HPV prevalence range is very wide, and it is influenced by the demographic and ethnic differences of the populations investigated, as well as the different diagnostic procedures [2].…”

“…Despite the fact that oral transmission of HPV is unclear, different sexual habits, such as the onset of sexual activity at an earlier age, an increase in the number of partners, and orogenital sex have made HPV an endemic infection [2]. As a result, some studies have shown the role of viruses in head and neck cancer [15][16][17].…”

“…HPV was reported in several benign oral lesions, especially verruca vulgaris, squamous papilloma, and the rare focal epithelial hyperplasia [2]. Malignant [20].…”

“…Human Papillomavirus (HPV) is one of the most frequent sexually transmitted infections (STIs) that could play a role in the pathogenesis of head and neck cancer. This infection is a major health problem worldwide that manifests as progressive squamous dysplasia and results from cumulative genetic and epigenetic alterations induced by exposure to carcinogenic agents [1,2].…”

Oral squamous papilloma: a view under clinical, fluorescence and histopathological aspects

“…Oral squamous papilloma is a benign tumor and its pathogenesis has been associated with human papillomavirus (HPV) infection. (1)(2)(3)(4)(5) The HPV einstein (São Paulo). 2019;17(2):1-4 infection is one of the risk factors associated with the development of cervical, anogenital, pharynx, larynx and oral cavity carcinomas.…”