Background: The medical aesthetics industry is a very profitable and rapidly growing branch of medicine. Currently, somatologists or beauty therapists who either independently perform or assist medical directors in these aesthetic procedures, are not regulated by a professional body in most countries including South Africa. The absence of a prescribed scope of practice, attributed to absence of formal professional regulation, has resulted in an increase in anecdotal reports of complications and malpractice being referred to medical professionals. Since the mandate of regulatory bodies is to guide the professions and to protect patients and the public, currently, the absence of regulation in the somatology profession exposes patients/clients to unsafe practices predominately in the private sector. The objective of this scoping review is to map evidence on the somatology practices and regulations for non-medical aesthetic treatments. Methods: We will conduct a scoping review using peer reviewed journal articles that present literature on the practice of non-medical aesthetic treatments. Grey literature including media reports, and unpublished theses will be included. Electronic searches of databases and search engines such as Scopus, CINAHL, EBSCOhost, Health Source - Consumer Edition; Health Source: Nursing/Academic Edition, Open Dissertations, Google Scholar and MEDLINE will be undertaken to attain published articles and reports from all study designs. Duplicated documents will be deleted prior to title screening commencing. All retrieved literature will be exported into an Endnote X20 library. The quality of each publication will be appraised using the mixed methods appraisal tool (MMAT) – version 2018.Discussion: We will map the evidence of how non-medical treatments are commonly being performed by non-physicians and somatologists, including identifying which treatments and procedures are more at risk in resulting in adverse reactions if not administered ethically or correctly. Once summarised, the data could be used to develop relevant and current good practice guidelines that could be later integrated into a framework for somatologists performing non-medical aesthetics treatments in South Africa. Systematic review registration: Open Science Framework registration (https://osf.io/4fk8g/)