Real-World Experiences of Patients With Cellulite: Implications for Newer Treatment Modalities

Wang, Jordan V; Bajaj, Shirin; Mehrabi, Joseph N; Geronemus, Roy G.

doi:10.1097/dss.0000000000003551

Cited by 3 publications

(5 citation statements)

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“…Previous studies have indicated that women with cellulite often experience psychological distress and low self-esteem, particularly in social settings. 12 , 13 Future studies that elucidate the potential impact of RAP treatment on psychological distress and quality of life are warranted. Treatment with the acoustic subcision device was also well-tolerated, as evidenced by the lack of device or treatment-related UAEs or SAEs in participants.…”

Section: Discussionmentioning

confidence: 99%

“…11 Studies and surveys have demonstrated that cellulite can negatively affect self-esteem, body image, and quality of life. 12,13 Current treatment options for cellulite include vacuumassisted manual subcision of septa via microblade, thermal lipolysis of adipocytes and thermal subcision of septa by lasers, or chemical subcision via collagenase clostridium histolyticum injections. [14][15][16] Recently, Kaminer and colleagues 17 showed lasting improvement in the appearance of cellulite via mechanical subcision of fibrous septa.…”

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confidence: 99%

“… 11 Studies and surveys have demonstrated that cellulite can negatively affect self-esteem, body image, and quality of life. 12 , 13 …”

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confidence: 99%

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Improvement in Cellulite Appearance After a Single Treatment Visit With Acoustic Subcision: Long-Term Findings From a Multicenter Clinical Trial

Tanzi,

Capelli,

Robertson

et al. 2023

Dermatol Surg

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BACKGROUND Cellulite is an aesthetically displeasing rippling or dimpling of the skin, primarily on the buttocks/thighs. A recent study showed a novel acoustic subcision device produced significant short-term (12-week) improvement in the appearance of cellulite after a single rapid acoustic pulse (RAP) treatment. OBJECTIVE To evaluate the long-term (>52-weeks) efficacy and safety of RAP treatment for improvement in the appearance of cellulite. MATERIALS AND METHODS In this prospective, multicenter trial, female participants (n = 42) with severe cellulite were treated with the acoustic subcision device in a single visit. At >52 weeks, blinded board-certified dermatologists assessed efficacy by correctly identifying post-treatment photographs and using a 6-point simplified Cellulite Severity Scale (CSS). Participant satisfaction was also collected. Safety was assessed throughout. RESULTS The blinded panel correctly identified post-treatment photographs at a rate of 95.2%; 70.4% of participants had a >1-point reduction in the CSS score from baseline (mean reduction of 1.09). All participants (100%) reported improved cellulite appearance. Overall pain during treatment was rated as 2.4 and 0.3 post-treatment (pain scale 0–10). No device or treatment-related adverse events were reported at the >52-week follow-up. CONCLUSION Rapid acoustic pulse treatment significantly improved the long-term appearance of cellulite and was well-tolerated.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Improvement in Cellulite Appearance After a Single Treatment Visit With Acoustic Subcision: Long-Term Findings From a Multicenter Clinical Trial

Tanzi,

Capelli,

Robertson

et al. 2023

Dermatol Surg

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“…2 Although physically benign, cellulite is a psychologically distressing condition that drives many to seek treatment. 4,5 Available therapeutic options include topical agents, injectables, energy-based modalities, and surgical procedures, which provide varying levels of efficacy. 6 Specifically, invasive subcision techniques that sever and release the fibrous septa have been shown to lead to better and more durable responses than techniques targeting other features such as adipocytes, when performed in appropriate patients.…”

Section: Introductionmentioning

confidence: 99%

“…Although physically benign, cellulite is a psychologically distressing condition that drives many to seek treatment 4,5 . Available therapeutic options include topical agents, injectables, energy‐based modalities, and surgical procedures, which provide varying levels of efficacy 6 .…”

Section: Introductionmentioning

confidence: 99%

Comparing safety and efficacy of acoustic subcision at two different rapid acoustic pulse rates to improve the appearance of cellulite

Biesman,

Capelli

2023

Lasers Surg Med

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BackgroundA recent study showed the safety and efficacy of a noninvasive acoustic subcision device to improve the appearance of cellulite via delivery of rapid acoustic pulses in a single treatment visit.ObjectiveTo evaluate and compare the safety and efficacy of a single rapid acoustic pulse treatment visit using an equivalent number of rapid acoustic pulses at a pulse rate of 100 or 50 Hz.MethodsThis single‐center, prospective study enrolled 15 adult women with moderate to severe cellulite according to the Cellulite Dimple—At Rest Scale. Each participant would receive nominally 72,000 rapid acoustic pulses at a pulse rate of 50 Hz on the left buttock and thigh, and nominally 72,000 rapid acoustic pulses at a pulse rate of 100 Hz on the right buttock and thigh within one treatment visit. Efficacy was assessed by the ability of blinded, independent reviewers to correctly distinguish the pre‐ and post‐treatment photos, participant satisfaction, and the change in Cellulite Dimple—At Rest scores for each treatment side. Safety was monitored throughout the conduct of the study.ResultsFor both 100 and 50 Hz pulse rate treated areas, the majority (two out of three) of blinded reviewers correctly identified 100% of the pre/post‐treatment photos. For both the 100 and 50 Hz treated areas, 80% of participants agreed/strongly agreed that their cellulite appeared improved at the 12‐week follow‐up visit. Significant improvements in Cellulite Dimple—At Rest scores were seen for both the 100 and 50 Hz treated areas. All participants thought both the 100 and 50 Hz pulse rate treatments were tolerable, and the pain (mean score ± SD; 2.2 ± 1.2) associated with each was identical. No unexpected or serious adverse events occurred.ConclusionAcoustic subcision delivered via rapid acoustic pulses at 100 Hz, compared to 50 Hz, provides equivalent improvement in the appearance of cellulite while maintaining a similar safety and efficacy profile. For both pulse rates, treatment pain was minimal, and participant satisfaction was high.

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High-Intensity, High-Frequency, Parallel Ultrasound Beams for Cellulite of the Buttocks and Thighs

Wang,

Ugonabo,

Bajaj

et al. 2024

Dermatol Surg

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BACKGROUND Ultrasound energy can successfully treat fine lines and wrinkles, as well as lift the eyebrow and submentum. Ultrasound waves of high intensity induce thermal injury in the dermis with subsequent tissue remodeling. OBJECTIVE To examine the utility of a novel ultrasound device that utilizes high-intensity, high-frequency, parallel ultrasound beams to improve the clinical appearance of cellulite on the thighs and buttocks. MATERIALS AND METHODS A prospective, multicenter, clinical study investigated this novel ultrasound device using 2 treatments. RESULTS Sixty-five subjects completed both treatments. The mean age was 46 years, and 100% were women. Fitzpatrick skin types I to VI were represented. Assessments compared 3-month follow-up with baseline. Two blinded reviewers agreed in identifying pretreatment and post-treatment photographs for 89.2%. For Cellulite Severity Scale rating, there was significant improvement of 1.61 units (p < .001). For cellulite Global Aesthetic Improvement Scale (GAIS), 89.2% had improvement, with a mean of 0.87 units (p < .001). For Laxity Scale rating, there was significant improvement of 0.70 units (p < .001). For skin laxity GAIS, 89.2% had improvement, with a mean of 0.76 units (p < .001). No device-related adverse events occurred. CONCLUSION A novel ultrasound device that utilizes high-intensity, high-frequency, parallel ultrasound beams can safely and effectively improve the clinical appearance of cellulite on the thighs and buttocks.

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Real-World Experiences of Patients With Cellulite: Implications for Newer Treatment Modalities

Cited by 3 publications

References 5 publications

Improvement in Cellulite Appearance After a Single Treatment Visit With Acoustic Subcision: Long-Term Findings From a Multicenter Clinical Trial

Improvement in Cellulite Appearance After a Single Treatment Visit With Acoustic Subcision: Long-Term Findings From a Multicenter Clinical Trial

Comparing safety and efficacy of acoustic subcision at two different rapid acoustic pulse rates to improve the appearance of cellulite

High-Intensity, High-Frequency, Parallel Ultrasound Beams for Cellulite of the Buttocks and Thighs

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