National collection of embryo morphology data into Society for Assisted Reproductive Technology Clinic Outcomes Reporting System: associations among day 3 cell number, fragmentation and blastomere asymmetry, and live birth rate

Racowsky, Catherine; Stern, Judy E.; Gibbons, William E.; Behr, Barry; Pomeroy, Kimball O.; Biggers, John D.

doi:10.1016/j.fertnstert.2011.02.009

Cited by 103 publications

(78 citation statements)

References 27 publications

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“…In our companion paper (9) we show that the other collected fields-fragmentation, symmetry, and cell number-can be used to predict live birth in a manner that is consistent with that previously shown in a single program (11). Together, these observations show that the SART morphology collection system has validity for use in future studies of ART practice and outcome.…”

Section: Vernon Correspondence Fertil Steril 2011supporting

confidence: 76%

“…For cleavage-stage embryos, this system was accompanied by additional information on embryo cell number, fragmentation, and symmetry scores (7,8,9). Laboratories were also asked to identify which of five optical systems was used in assessing embryos for transfer: bright field illumination only, phase contrast, polarized light, Hoffman optics, Nomarski optics (differential interference contrast), or other.…”

mentioning

confidence: 99%

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Utility of the national embryo morphology data collection by the Society for Assisted Reproductive Technologies (SART): correlation between day-3 morphology grade and live-birth outcome

Vernon

Stern

Ball

et al. 2011

Fertility and Sterility

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Section: Vernon Correspondence Fertil Steril 2011supporting

confidence: 76%

mentioning

confidence: 99%

Utility of the national embryo morphology data collection by the Society for Assisted Reproductive Technologies (SART): correlation between day-3 morphology grade and live-birth outcome

Vernon

Stern

Ball

et al. 2011

Fertility and Sterility

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“…On day 3 all embryos were checked for cell number, fragmentation and cell symmetry, then embryos were scored according to SART scoring system [1]. In order to compile day 3 embryo data for comparison between patients, we developed a composite grade for all embryo dispositions by patient (embryos transferred, frozen or discarded).…”

Section: Methodsmentioning

confidence: 99%

“…Grading of day 3 embryos comprises cell number, degree of fragmentation, cell symmetry and presence or absence of cytoplasmic pitting, and has been shown to predict ART outcomes [1][2][3]. Better morphology grade embryos have been associated with significantly improved implantation rates and live birth rates [4,5].…”

Section: Introductionmentioning

confidence: 99%

Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF

Berger

Zapantis

Merhi

et al. 2014

J Assist Reprod Genet

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Purpose The association between pronuclear (PN) scoring of embryos from assisted reproductive technology (ART) and clinical pregnancy remains controversial. We hypothesized that embryos with PNs scored on the day of fertilization check offer better embryo selection on day 3 and higher CPR compared to non-PN scored embryos. Methods Patients (19-46 years) undergoing IVF/ICSI cycles at Montefiore's Institute for Reproductive Medicine and Health between January 2006 and December 2009 were included in our study. We analyzed fresh day 3 cycles only with autologous oocytes and partner's fresh sperm (n=344). A total of 1,899 embryos were included. We compared CPR from non-PN scored embryos (Group 1, n=835) with PN scored embryos (Group 2, n=1,064). Composite scores by patient were developed based on embryo disposition. We also assessed traditional embryo grading derived from cell number, fragmentation and cell symmetry. Data analysis included chi square and t test to determine if PN scoring was associated with improved CPR, and to compare the additional variables.Results CPR between Group 1 and Group 2 were not different (p=0.91). CPR was significantly associated with female age, number of mature oocytes retrieved, number of day 3 embryos and grade of embryos transferred on day 3 (p<0.05). Conclusion PN scoring was not associated with improved CPR in day 3 embryo transfers. Mean grade of transferred embryos continues to be a well-established, independent predictor of CPR. We conclude that further refinement of embryo grading by PN scoring is not beneficial.

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“…Slow cleavage and cell division arrest have been associated with chromosomal abnormalities in embryos such as mosaicism, polyspermia, and aneuploidies [5]. Also, it is well known that on day 3 after oocyte retrieval, 8-cell embryos are the best predictors of embryo quality [6][7][8]. However, there is limited information in the literature about the clinical outcome of faster developing embryos (> 10-cell) transferred on day 3.…”

Section: Introductionmentioning

confidence: 99%

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

Zhao

Liu

et al. 2019

Gynecol Obstet Invest

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Background/Aim: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3. Methods: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Seven hundred and forty four patients, with 1 blastocyst transferred derived from > 10-cell (n = 183) or 8-cell (n = 561) good quality embryos on day 3, were assigned in the frozen ET (FET) group. Results: In the ET group, the clinical pregnancy and live birth rates of the > 10-cell transfer patients were comparable with those of the 8-cell transfer group (62.67 vs. 69.27%, 60.00 vs. 59.90%, respectively); however, the miscarriage rate of > 10-cell transfers was significantly lower than that of 8-cell transfers (4.26 vs. 13.53%, p < 0.05). In the FET group, there were no statistically significant differences found in the clinical pregnancy, live birth, and miscarriage rates between one > 10-cell-derived and one 8-cell-derived blastocyst transfers (71.04 vs. 65.78%, 59.02 vs. 54.19%, and 16.92 vs. 17.62%, respectively). Conclusions: The results suggested that > 10- and 8-cell, good quality embryos on day 3, had comparable viability and clinical outcomes.

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National collection of embryo morphology data into Society for Assisted Reproductive Technology Clinic Outcomes Reporting System: associations among day 3 cell number, fragmentation and blastomere asymmetry, and live birth rate

Cited by 103 publications

References 27 publications

Utility of the national embryo morphology data collection by the Society for Assisted Reproductive Technologies (SART): correlation between day-3 morphology grade and live-birth outcome

Utility of the national embryo morphology data collection by the Society for Assisted Reproductive Technologies (SART): correlation between day-3 morphology grade and live-birth outcome

Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study

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