NatA is required for suspensor development in Arabidopsis

Feng, Jinlin; Ma, Ligeng

doi:10.1080/15592324.2016.1231293

Cited by 3 publications

(2 citation statements)

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“…In A. thaliana, NAA10 and NAA15 are classified as embryo defective genes [61]. Indeed, characterization of A. thaliana T-DNA insertion mutant NAA10 and NAA15 lines confirmed that loss of both subunits arrested embryos at the dermatogen to early globular stage and that AtNatA is required for the asymmetric division of the hypophysis, root meristem formation, and proper suspensor development [13,62,63]. Additionally, artificial miRNA (ami) AtNAA10 and AtNAA15 lines displayed severe developmental defects and growth retardation compared to wild-type A.…”

Section: Physiological Relevance Of Nats In Phototrophic Organismsmentioning

confidence: 98%

Evolution-Driven Versatility of N Terminal Acetylation in Photoautotrophs

Giglione

Meinnel

2021

Trends in Plant Science

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Section: Physiological Relevance Of Nats In Phototrophic Organismsmentioning

confidence: 98%

Evolution-Driven Versatility of N Terminal Acetylation in Photoautotrophs

Giglione

Meinnel

2021

Trends in Plant Science

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“…This enzymatic process is catalyzed by a group of N-terminal acetyltransferases (NATs) and plays a pivotal role in various cellular processes, including protein stability, protein-protein interactions, and cellular localization (Aksnes et al, 2015; Bienvenut et al, 2012; Dikiy & Eliezer, 2014). There are seven known NAT types, with NatA being the most prominent, believed to be responsible for modifying 40-50% of the human proteome(Deng et al, 2019; Feng & Ma, 2016; Van Damme, 2021). The NatA complex is composed of the catalytic sub-unit NAA10, and the auxiliary sub-units NAA15 and HYPK (Deng et al, 2019; Dörfel et al, 2017; Feng et al, 2016; Knorr et al, 2019; Weidenhausen et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

A Natural History ofNAA15-related Neurodevelopmental Disorder Through Adolescence

Makwana,

Christ,

Patel

et al. 2024

Preprint

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NAA15 is a member of the NatA N-terminal acetyltransferase complex which acts by interacting with the NAA10 enzymatic sub-unit. Individuals with variants in the NAA15 coding region develop NAA15-related neurodevelopmental syndrome which presents with a wide array of manifestations that affect the heart, brain, musculoskeletal system, and behavioral and cognitive development. We tracked a cohort of 26 participants (8 females and 18 males) over time, each with a pathogenic NAA15 variant, and administered the Vineland-3 assessment to them to assess their adaptive functioning. We found that the cohort performed significantly worse compared to the normalized Vineland values. On average, females performed better than males across all domains. They performed significantly better on the Motor Domain and Fine Motor Sub-Domain portions of the assessment. Over time, females showed a decrease in adaptive functioning with the decline being especially strongly correlated at the Coping sub-domain, Domestic sub-domain, and Fine motor sub-domains. It is difficult to determine the strength of these correlations due to limited power. Males (after excluding one outlier) showed a moderate positive correlation between age and ABC standard score. Ultimately, additional longitudinal data should be collected to determine the validity of the between sex-differences and to better understand the change in adaptive behavioral outcomes of individuals with NAA15-neurodevelopmental disorder as they age.

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The short and intricate life of the suspensor

Downs

2020

Physiologia Plantarum

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The suspensor is a short‐lived tissue critical for proper embryonic development in many higher plants. While the tissue was initially thought to simply suspend the embryo in the endosperm, it has been found through decades of research that it serves multiple important purposes. The suspensor has been found to be vital for proper embryo patterning and numerous studies have been undertaken into the complex transcriptional cross‐talk between the suspensor and the embryo proper. Indeed, many suspensor mutants also display abnormalities in the embryo. The suspensor's role as a nutrient conduit has been shown using ultrastructural and histochemical techniques. Biochemical approaches have found that the suspensor is a centre of early embryonic hormone production in several species. The suspensor has also been frequently used as a model for programmed cell death as it shows signs of termination almost immediately upon developing. This review covers the essential functions of the suspensor throughout its short existence from multiple disciplines including structural, genetic and biochemical perspectives.

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NatA is required for suspensor development in Arabidopsis

Cited by 3 publications

References 31 publications

Evolution-Driven Versatility of N Terminal Acetylation in Photoautotrophs

Evolution-Driven Versatility of N Terminal Acetylation in Photoautotrophs

A Natural History ofNAA15-related Neurodevelopmental Disorder Through Adolescence

The short and intricate life of the suspensor

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