NASPGHAN Capsule Endoscopy Clinical Report

Friedlander, Joel A.; Liu, Quin Y.; Sahn, Benjamin; Kooros, Koorosh; Walsh, Catharine M.; Krämer, Robert; Lightdale, Jenifer R.; Khlevner, Julie; McOmber, Mark; Kurowski, Jacob A.; Giefer, Matthew J.; Pall, Harpreet; Troendle, David M.; Utterson, Elizabeth C.; Brill, Herbert; Zacur, George M.; Lirio, Richard A.; Lerner, Diana; Reynolds, Carrie; Gibbons, Troy; Wilsey, Michael; Liacouras, Chris A.; Fishman, Douglas S.

doi:10.1097/mpg.0000000000001413

Cited by 29 publications

(29 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study reported that use of PC is a useful screening tool in adolescents, 31 but it is controversial whether younger children should undergo PC examination because they cannot swallow the PC and sedation solely for endoscopic deployment of PC is not recommended. 32 At the same time, several studies have shown that radiological SB imaging, such as barium SB follow through, computed tomographic enteroclysis and magnetic resonance enteroclysis does not exclude SB stenosis. 30 , 32 Our low capsule retention rate can be explained by careful patient selection with frequent use of PC in patients older than 10 years.…”

Section: Discussionmentioning

confidence: 99%

“… 32 At the same time, several studies have shown that radiological SB imaging, such as barium SB follow through, computed tomographic enteroclysis and magnetic resonance enteroclysis does not exclude SB stenosis. 30 , 32 Our low capsule retention rate can be explained by careful patient selection with frequent use of PC in patients older than 10 years.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Video capsule endoscopy in pediatric patients with Crohn’s disease: a single-center experience of 180 procedures

Németh

Agardh

Johansson

et al. 2018

Therap Adv Gastroenterol

View full text Add to dashboard Cite

BackgroundVideo capsule endoscopy (VCE) is a noninvasive method enabling excellent visualization of the small bowel (SB) mucosa. The aim of this study was to examine the impact and safety of VCE performed in children and adolescents with suspected or established Crohn’s disease (CD).MethodsA total of 180 VCE examinations in 169 consecutive patients conducted in 2003–14 in a single center were retrospectively analyzed. The median age was 13 years (range 3–17 years) and indications for VCE were suspected (125 cases, 69%) and established (55 cases, 31%) CD. VCE was performed with a PillCam SB (Given Imaging, Yokneam, Israel) VCE system with 8–12 h of registration without bowel preparation.ResultsA total of 154 of 180 (86%) patients swallowed the capsule and 26 (14%) had the capsule endoscopically placed in the duodenum. Patency capsule examination was performed in 71 cases prior to VCE to exclude SB obstruction. VCE detected findings consistent with SB CD in 71 (40%) examinations and 17 (9%) procedures showed minor changes not diagnostic for CD. A total of 92 (51%) examinations displayed normal SB mucosa. The capsule did not reach the colon within the recording time in 30 (17%) procedures and were defined as incomplete examinations. A change in diagnosis or therapy was recommended in 56 (31%) patients based on VCE results. Capsule retention occurred in one patient.ConclusionsVCE is a safe method in children with suspected or established CD. VCE often leads to a definitive diagnosis and has a significant impact on the clinical management of pediatric patients with CD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Video capsule endoscopy in pediatric patients with Crohn’s disease: a single-center experience of 180 procedures

Németh

Agardh

Johansson

et al. 2018

Therap Adv Gastroenterol

View full text Add to dashboard Cite

show abstract

“…The indications for VCE in the pediatric population outlined in the ESPHGAN guidelines were followed. [ 3 ] VCE was used when a diagnosis could not be confirmed with gastroscopy or to supplement the diagnosis reached via colonoscopy. The groups were identified by their chief complaints and main clinical features.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…[ 1 , 2 ] The United States Food and Drug Administration approved the use of CE for the evaluation of small bowel diseases in adults in 2001. In 2004, CE was approved for children 10 years or older; [ 3 ] Both CE and patency capsules were approved for use in children older than 2 years in 2009. [ 4 ] VCE is used for the diagnosis and assessment of the extent of disease in the small bowel, such as for Crohn's disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical features of capsule endoscopy in 825 children

Huang

Wang

et al. 2020

Medicine

View full text Add to dashboard Cite

Video capsule endoscopy (VCE) can detect mucosal lesions in the intestine, especially in the small bowel. Our study aims to evaluate the applications of VCE for pediatric gastrointestinal diseases. In this retrospective study, we included all patients who underwent VCE between December 2012 and December 2018. Clinical information and VCE data were analyzed. Among 828 patients, the completion rate was 99.6% (n = 825), with an average age of 10.2 ± 3.3 years old. A total of 459 VCE procedures showed abnormalities, and the overall diagnostic yield was 55.6%. The most common indications for VCE were abdominal pain among 505 (61.2%) patients and hematochezia (10.1%) among 83. Among the positive results of VCE, small bowel ulcers accounted for the highest percentage (57.7%), of which 164 cases were diagnosed as inflammatory bowel disease. For obscure gastrointestinal bleeding, 12 cases were diagnosed as Meckel's diverticulum. In terms of the small bowel transit time of VCE, compared with the negative group [288 (216.5, 390.3) min] and the enteritis group [277 (192.5, 374.8) min], a longer transit time was needed in the small bowel ulcer group [332.5 (240, 451.5) min, P < .01]. There were no correlations of positive VCE findings with anemia, the white blood cell count, the C-reactive protein level or the small bowel transit time according to Spearman rank analysis. VCE is relatively well tolerated and safe in children and has great value for the diagnosis and treatment of abdominal pain, especially inflammatory bowel disease and obscure gastrointestinal bleeding.

show abstract

“…Several studies have been performed to identify risk factors associated with CR. CR rate does not correlate with capsule size (13)(14)(15)(16)(17), and/or patient's age (18)(19)(20). Conversely, the rate strictly depends on clinical indication.…”

Section: Preventing Crmentioning

confidence: 97%

Capsule retention: prevention, diagnosis and management

Rondonotti¹

2017

Ann. Transl. Med.

View full text Add to dashboard Cite

Capsule retention (CR) has been defined as capsule remaining in the digestive tract for a minimum of two weeks. CR occurs approximately in 2% of all patients undergoing small bowel capsule endoscopy (CE). Prompt diagnosis of CR is important, as it has relevant clinical implications. CR should be suspected in (I) all asymptomatic patients who do not report capsule excretion within 15 days from capsule ingestion; and (II) patients with obstructive or perforation-related symptoms in which the capsule has not been excreted, regardless of the time between the onset of symptoms and capsule ingestion. Abdominal plain X-ray is the preferred test to confirm CR. An abdominal CT scan should be performed, on individual basis, if knowledge of the precise location of the retained capsule is necessary or whenever clinically indicated. Since CR is usually asymptomatic, an initial watchful monitoring is suggested. In inflammatory bowel disease (IBD) patients, a short course of medical therapy may allow capsule excretion. Nevertheless, in long-term CR, some cases of capsule fragmentation, acute obstruction and perforation have been described. Therefore, retrieval of the retained capsule is recommended if asymptomatic CR lasts for long time. A safe capsule retrieval is usually performed by endoscopy, whereas surgery remains a viable alternative if the first is unsuccessful or when clinically indicated. Either Patency Capsule (PC) or dedicated small bowel cross-sectional imaging techniques have been proposed to prevent CR. Both have pros and cons, but head-to-head comparative studies are lacking.

show abstract

NASPGHAN Capsule Endoscopy Clinical Report

Cited by 29 publications

References 107 publications

Video capsule endoscopy in pediatric patients with Crohn’s disease: a single-center experience of 180 procedures

Video capsule endoscopy in pediatric patients with Crohn’s disease: a single-center experience of 180 procedures

Clinical features of capsule endoscopy in 825 children

Capsule retention: prevention, diagnosis and management

Contact Info

Product

Resources

About