Nasopharyngeal Angiofibroma: True Neoplasm or Vascular Malformation?

Beham, Alfred; Beham‐Schmid, Christine; Regauer, Sigrid; Auböck, L; Stammberger, Heinz R.

doi:10.1097/00125480-200007010-00006

Cited by 126 publications

(86 citation statements)

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“…The recurrence rate was found to be 7.5% in our series and all recurrent presented with intermittent epistaxis. Baham et al [13] carried out immunohistological and electron microscopic examination of nasopharyngeal angiofi broma and found unusual vascular architect suggesting it to be a vascular malformation. Nagai et al [14] found signifi cantly increased expression of growth factor, such as insulin-like growth factor II (IGF-II), in biopsies of 25 juvenile nasopharyngeal angiofi bromas and suggested that IGF-II might be a potential growth regulator on nasopharyngeal angiofi broma…”

Section: Discussionmentioning

confidence: 99%

Juvenile nasopharyngeal angiofibroma—our experience at a referral hospital

Sinha

Ninama

Prajapati

et al. 2009

Indian J Otolaryngol Head Neck Surg

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Nasopharyngeal angiofi broma is a rare, highly vascular locally invasive tumor with a strong tendency to bleed. It usually occurs in young adolescent males. This is a retrospective study of 53 patients with nasopharyngeal angiofi broma. All the cases were treated surgically by different conventional approaches depending upon the extent of the mass. Transpalatal approach was used in 32 cases, lateral rhinotomy in 13 cases and a combination of transpalatine + lateral rhinotomy + caldwel-luc in 8 cases. There is no recurrence in 49 cases till date. However, recurrence was noted in four cases within six months. Three out of four patients with recurrence had to undergo repeat surgery for the removal of angiofi broma within six months while the remaining one was referred to radiotherapy as the mass was invading the cavernous sinus. The various clinical presentation and treatment modalities are discussed.

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Section: Discussionmentioning

confidence: 99%

Juvenile nasopharyngeal angiofibroma—our experience at a referral hospital

Sinha

Ninama

Prajapati

et al. 2009

Indian J Otolaryngol Head Neck Surg

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“…Juvenile nasopharyngeal angiofibromas are rare, histologically benign, locally invasive tumors 57 or vascular malformations 9 of the nasopharynx that are found primarily in the pubescent male. We have recently reported on a 12-year-old boy who harbored paranasal tumor that extended into the cavernous sinus; we performed preoperative embolization and then resected the lesion via a subfrontal transbasal approach, orbitozygomatic osteotomy, lateral rhinotomy, and medial maxillotomy.…”

Section: Juvenile Nasopharyngeal Angiofibromas Of the Middle Cranial mentioning

confidence: 99%

Tumors of the skull base in children: review of tumor types and management strategies

Tsai¹,

Santoreneos²,

Rutka³

2002

FOC

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Although many treatment strategies for skull base tumors in adults have been reported, relatively little has been reported regarding such therapies in the pediatric population. Skull base tumors in children present a therapeutic challenge because of their unique pathological composition, the constraints of the maturing skull and brain, and the small size of the patients. In this review, the authors examine the pediatric skull base lesions that occur in the anterior, middle, and posterior cranial base, focusing on unique pediatric tumors such as encepahalocele, fibrous dysplasia, esthesioneuroblastoma, craniopharyngioma, juvenile nasopharyngeal angiofibroma, cholesteatoma, chordoma, chondrosarcoma, and Ewing sarcoma. They review management strategies that include radio- and chemotherapy, as well as surgical approaches with emphasis on the modifications and complications associated with the procedures as they apply in children. Evidence for the advantages and limitations of radiotherapy, chemotherapy, and surgery as it pertains to the pediatric population will be examined. With a working knowledge of skull base anatomy and special considerations of the developing craniofacial skeleton, neurosurgeons can treat skull base lesions in children with acceptable morbidity and mortality rates. Outcomes in this population may be better than those in adults, in part because of the benign histopathology that frequently affects the pediatric skull base, as well as the plasticity of the maturing nervous system.

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“…The disorder typically occurs in adolescent males. Recently, some studies have reported that the lesion has an immunohistological and electron microscopic profile more consistent with a vascular malformation rather with a tumor (Beham et al, 1997(Beham et al, , 2000. The site of origin of JA appears to be the sphenopalatine foramen or the bone of the vidian canal.…”

Section: Juvenile Angiofibromamentioning

confidence: 96%