Nasolacrimal duct obstruction as a complication of iodine-131 therapy in patients with thyroid cancer

Abstract

NLDO may be considered as a side effect of I-131 therapy, especially with a cumulative dose of 11.1 GBq or more.

Nasolacrimal duct obstruction following radioactive iodine 131 therapy in differentiated thyroid cancers: review of 19 cases

“…Other possible causes (allergic or viral conjunctivitis, keratoconjunctivitis sicca, trichiasis, canaliculitis, iritis, and functional causes of excessive tears) should be ruled out to reach a definitive diagnosis of 131 I therapy-acquired NLDO. 14 131 I therapy-acquired NLDO is defined as: 1) the presence of NLDO in 131 I therapy-treated patients; 2) an 131 I dose–NLDO relationship; 3) immediate onset of symptoms after 131 I therapy; and 4) the bilateral nature of NLDO in most of cases. CT dacryography using diluted contrast medium was found to be an easy and highly sensitive tool to evaluate NLDO in our cohort, which endorsed the findings of Garcier et al 15…”

Adverse effects of radioactive iodine-131 treatment for differentiated thyroid carcinoma

“…Nasolacrimal obstruction (NLDO) after RAIT has been reported by several studies [90][91][92][93][94]. RAI uptake by Conclusion RAIT for DTC generally causes relatively mild shortterm toxicity and, infrequently, serious complications.…”

“…However, our study on the possible hazard of 131 I on the lacrimal drainage system, performed using dacryoscintigraphy, which has been proved to be a valuable method for this purpose [95], showed that 18% of exposed eyes had evidence of NLDO on scintigraphic images. The frequency of complete NLDO significantly increases when the cumulative dose of radioiodine exceeds 11.1 GBq (300 mCi) [90].…”

“…However, these effects can be overlapping, as some of the effects classified as early effects may well be seen later in life.Nasolacrimal obstruction (NLDO) after RAIT has been reported by several studies [90][91][92][93][94]. Although generally safe, radioiodine therapy has some potential side effects, classified as early and late complications, which we have reviewed in this paper.…”

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

“…Fard-Esfahani et al 48 evaluated nasolacrimal duct obstruction as a complication ofiodine-131 therapy in 81 patients with thyroid cancer. A total of 17 age-matched sex-matched individuals were selected as control group.…”