Nasal symptoms among residents in moldy housing

Ruoppi, Pirkko; Husman, Tuula; Reiman, Marjut; Nuutinen, Juhani; Hyvärinen, Anne; Nevalainen, Aino

doi:10.5271/sjweh.754

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…A similar result has been shown among habitants of dwellings where 5% developed asthma after living in damp and moldy homes [97]. Another study showed the presence of rhinitis among adult habitants in moldy dwellings [98]. In addition to rhinitis and asthma, general nasal symptoms such as irritated, stuffy or runny nose, have been shown together with other mucosal symptoms, such as coughing, hoarseness and dry throat and irritated eyes [93].…”

Section: Damp and Moldy Buildingssupporting

confidence: 58%

Upper Airway Mucosal Inflammation : Proteomic Studies after Exposure to Irritants and Microbial Agents

Fornander¹

2015

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People are, in their daily lives, exposed to a number of airborne foreign compounds that do not normally affect the body. However, depending on the nature of these compounds, dose and duration of exposure, various airway symptoms may arise. Early symptoms are often manifested as upper airway mucosal inflammation which generates changes in protein composition in the airway lining fluid.This thesis aims at identifying, understanding mechanisms and characterizing protein alterations in the upper airway mucosa that can be used as potential new biomarkers for inflammation in the mucosa. The protein composition in the mucosa was studied by sampling of nasal lavage fluid that was further analyzed with a proteomic approach using two-dimensional gel electrophoresis and mass spectrometry. Additionally, by studying factors on site through environmental examination, health questionnaires and biological analyses, we have tried to understand the background to these protein alterations and their impact on health.Respiratory symptoms from the upper airways are common among people who are exposed to irritative and microbial agents. This thesis have focused on personnel in swimming pool facilities exposed to trichloramine, metal industry workers exposed to metalworking fluids, employees working in damp and moldy buildings and infants diagnosed with respiratory syncytial virus infection. The common denominator in these four studies is that the subjects experience upper airway mucosal inflammation, which is manifested as cough, rhinitis, phlegm etc. In the three occupational studies, the symptoms were work related. Notably, a high prevalence of perceived mucosal symptoms was shown despite the relatively low levels of airborne irritants revealed by the environmental examination. Protein profiling verified an ongoing inflammatory response by identification of several proteins that displayed altered levels. Interestingly, innate immune proteins dominated and four protein alterations occurred in most of the studies; SPLUNC1, protein S100A8 and S100A9 and alpha-1-antitrypsin. Similarly, these proteins were also found in nasal fluid from children with virus infection and in addition a truncated form of SPLUNC1 and two other S100 proteins (S100A7-like 2 and S100A16), not previously found in nasal secretion, were identified.Altogether, the results indicate the potential use of a proteomic approach for identifying new biomarkers for the upper respiratory tract at an early stage in the disease process after exposure to irritant and microbial agents. The results indicate an effect on the innate immunity system and the proteins; SPLUNC1, protein S100A8 and S100A9 and alpha-1-antitrypsin are especially promising new biomarkers. Moreover, further studies of these proteins may help us to understand the molecular mechanisms involved in irritant-induced airway inflammation. POPULÄRVETENSKAPLIG SAMMANFATTNING FÖRÄNDRAD PROTEINSAMMANSÄTTNING I DE ÖVRE LUFTVÄGARNA EFTER EXPONERING FÖR SLEMHINNEIRRITERANDE ÄMNENVarje dag utsätts vi för partikla...

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Section: Damp and Moldy Buildingssupporting

confidence: 58%

Upper Airway Mucosal Inflammation : Proteomic Studies after Exposure to Irritants and Microbial Agents

Fornander¹

2015

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“…Although IgE-mediated sensitization to some molds recently has been identified as a risk factor for adulthood asthma, 12 this evaluation supports the previous conclusion that the majority of the nasal symptoms in moisture-damaged buildings are other than immediate IgE-mediated allergy. 13…”

Section: Discussionmentioning

confidence: 99%

Inhalation Challenge Test in the Diagnosis of Occupational Rhinitis

Airaksinen¹,

Tuomi

Tuppurainen

et al. 2008

American Journal of Rhinology

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“…Environmental stimulants, including indoor allergens, can affect the development of allergic responses [ 3 ]. Indoor allergens involved in this process can include arthropod allergens, mammalian allergens, fungal allergens, and also occupational allergens [ 3 – 6 ]. Occupational asthma and allergic rhinitis are common respiratory diseases in industrialized countries [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Occupational Allergic Diseases in Kitchen and Health Care Workers: An Underestimated Health Issue

Bilge

Ünlüoğlu

Son

et al. 2013

BioMed Research International

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Objective. This study evaluated the frequencies of allergic symptoms and rate of upper respiratory infections during the past year in the general population, kitchen workers (KW) and health care workers (HCW). Methods. The European Community Respiratory Health Survey (ECRHS) was used to inquire retrospectively about asthma and asthma-like symptoms and the number of treatments required for previous upper respiratory tract infections (URTI: acute pharyngitis, acute sinusitis, etc.) during the past year for health care workers, kitchen workers, and members of the general population. Adjusted odds ratios by gender, age, and smoking status were calculated. Results. 579 subjects (186 from the general population, 205 KW, and 188 HCW; 263 females, 316 males) participated in the study. Noninfectious (allergic) rhinitis was significantly higher in the HCW and KW groups than in the general population (P < 0.001). Cumulative asthma was significantly higher only in the HCW group (P < 0.05). In addition, the HCW and KW groups had significantly higher risks of ≥2/year URTI (OR: 1.59, 95% CI: 1.07–2.38 versus OR: 1.57, 95% CI: 1.05–2.38) than the general population. Conclusion. Occupational allergic respiratory diseases are an important and growing health issue. Health care providers should become familiar with workplace environments and environmental causes of occupational rhinitis and asthma.

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Nasal symptoms among residents in moldy housing

Cited by 7 publications

References 27 publications

Upper Airway Mucosal Inflammation : Proteomic Studies after Exposure to Irritants and Microbial Agents

Upper Airway Mucosal Inflammation : Proteomic Studies after Exposure to Irritants and Microbial Agents

Inhalation Challenge Test in the Diagnosis of Occupational Rhinitis

Occupational Allergic Diseases in Kitchen and Health Care Workers: An Underestimated Health Issue

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