Nasal septal and mucosal disease associated with pyoderma gangrenosum in a cocaine user

Cocaine‐induced pyoderma gangrenosum‐like lesions

“…Histopathologically, in addition to the diffuse dermal infi ltrate of neutrophils typical of classic forms of PG, distinctive traits such as fi brinoid necrosis, LCV and thrombotic vasculopathy have been described (Table 1 ). Furthermore, the reported immunological profi le resembles that of cases of RP induced by levamisole (Table 1 ) [ 1,[7][8][9][10][11][12][13][14] . Additionally, many patients with CIPG lesions presented with concomitant RP [ 1 ] .…”

Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature

“…3 It is thought to enhance its psychotropic effect, prolong the euphoria and act as an indirect serotonin agonist. 8,9 Levamisole was also found in heroin. 3 Beyond the skin manifestations, levamisole toxicity can manifest with several systemic adverse events including: fatigue, arthralgia, isolated neutropenia or leukopenia, agranulocytosis, seizure, pulmonary hemorrhage, hyponatremia and renal failure.…”

“…15 Few other cases with negative ANCA and APL like our patients are also described. 8,11,14,16 Establishing a specific immunologic/serologic profile for CIPG is therefore challenging, but positive p-ANCA is still the most frequent finding.…”

Pyoderma gangrenosum associated to the use of cocaine/levamisole. Series of three cases and literature review

“…PG associated with cocaine/levamisole is a recently described disease. Twenty-three cases published in the English-speaking literature were retrieved 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 9 , 11 ( Table 1 ), none of them in Colombia. Unlike the classic form, PG associated with cocaine is accompanied by vasculopathy and cutaneous or systemic vasculitis.…”

“…Artrhalgias (n = 1) ACL+ (n = 5), AL+ (n = 3), B2GP+ (n = 4) p-ANCA+ (n = 7), anti PR3+ (n = 4) y anti-MPO+ (n = 7), ANAs+ (n = 3) and FR+ (n = 1) Prednisone were administered in 6 of 8 patients. Gentle wound care and cocaine avoidance in all patients with improvement Yes 8 Carola Baliu-Piqué et al (2016) 9 40 F NR 2 weeks Breast, hips, upper and lower extremities Yes No No No Methylprednisolone bolus, cyclosporine, infliximab, and mycophenolic acid Yes 9 Ricardo Ruiz-Villaverde et al (2016) 7 38 M NR NR Armpits, chest, pubis, and lumbar region Yes No No No Prednisone Yes 10 Rahul Sehgal et al (2017) 8 53 F NR 6 months On the upper back. Ulceration of bilateral nasal passages and nasal septum perforation Yes No Right-sided multifocal pneumonitis and mild reactive lymphadenopathy.…”