Multifocal cocaine-induced pyoderma gangrenosum: A report of two cases and review of literature

Lemieux, Alexandre; Cai, Zhuo Ran; Bélisle, Annie; Chartier, Suzanne; Bolduc, Chantal

doi:10.1177/2050313x20935736

Cited by 3 publications

(2 citation statements)

References 17 publications

(42 reference statements)

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“…Behind pyoderma gangrenosum there may be underlying causes such as inflammatory bowel disease, or it may be secondary to identifiable causes such as cocaine use as in this patient [2,3] . This case is interesting not only because of the extension of the lesions, explained by the absence of previous treatment and the persistence of cocaine abuse, but also because of the low probability of the diagnosis made [4] .…”

Section: Discussionmentioning

confidence: 95%

Disseminated necrotic suppurative ulcers as a manifestation of cocaine abuse

García Tellado,

Lasa Teja,

Rodríguez Vidriales

et al. 2023

European Journal of Case Reports in Internal Medicine

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Introduction/Aims/Background: Pyoderma gangrenosum is an immune-mediated illness that can be caused by several affections, such as inflammatory bowel disease, rheumatoid arthritis, and drug use. We present a rare case of pyoderma gangrenosum induced by levamisole-adulterated cocaine. There have been few cases of this disease reported in the world. Levamisole is an anthelmintic drug used to adulterate cocaine to boost its effect. It also has immune-modulating effects causing, among others, vasculitis and dermatological problems. Materials and Methods: Clinical case of a 46-year-old man admitted to the hospital University Marqués de Valdecilla in Santander, Spain, in August 2022. We diagnosed pyoderma gangrenosum based on clinical, analytical, and histological parameters. Results: We report a case of pyoderma gangrenosum induced by consumption of levamisole-adulterated cocaine. Discussion: This patient suffered from a rare and extensive immune-mediated affection with characteristic primary lesions in the form of suppurative ulcers that responded to immunosuppressive treatment. Behind pyoderma gangrenosum there may be underlying conditions such as inflammatory bowel disease, or pyoderma gangrenosum may be secondary to identifiable causes such as cocaine use as in this patient.

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Section: Discussionmentioning

confidence: 95%

Disseminated necrotic suppurative ulcers as a manifestation of cocaine abuse

García Tellado,

Lasa Teja,

Rodríguez Vidriales

et al. 2023

European Journal of Case Reports in Internal Medicine

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“…Disease control was eventually achieved with oral corticosteroids together with mycophenolic acid, infliximab, and abstinence from cocaine consumption. Another case describes a 46-year-old man with a 1-year history of generalized PG resistant to treatments [ 6 ]. He presented with 22 cribriform ulcers and atrophic scars located predominantly on the trunk, with two lesions in the pre-auricular region previously treated with prednisone 50 mg daily combined with cyclosporine but had multiple disease relapses.…”

Section: Discussionmentioning

confidence: 99%