Nasal saline irrigations for the symptoms of chronic rhinosinusitis

Abstract

Saline irrigations are well tolerated. Although minor side effects are common, the beneficial effect of saline appears to outweigh these drawbacks for the majority of patients. The use of topical saline could be included as a treatment adjunct for the symptoms of chronic rhinosinusitis.

Nasal saline irrigation: therapeutic or homeopathic

“…In 2007, a Cochrane review on nasal saline therapy demonstrated a large shift in symptom improvement on meta-analysis of randomized controlled trials, with a 1.41 standardized mean difference (SMD) in favor of saline therapy. 2 This represents an improvement of 1.41 standard deviations on the symptom scale compared to placebo and compares favorably to the treatment effect observed in other sinonasal interventions with intranasal corticosteroids for CRS (SMD 0.49) and immunotherapy for AR (SMD 0.71). This large symptom effect underscores its growing popularity.…”

Nasal saline irrigation: therapeutic or homeopathic

“…In 2007, a Cochrane review on nasal saline therapy demonstrated a large shift in symptom improvement on meta-analysis of randomized controlled trials, with a 1.41 standardized mean difference (SMD) in favor of saline therapy. 2 This represents an improvement of 1.41 standard deviations on the symptom scale compared to placebo and compares favorably to the treatment effect observed in other sinonasal interventions with intranasal corticosteroids for CRS (SMD 0.49) and immunotherapy for AR (SMD 0.71). This large symptom effect underscores its growing popularity.…”

The management of cystic fibrosis chronic rhinosinusitis: An evidenced‐based review with recommendations

“…The use of saline irrigations is better studied in patients with non-CF CRS, in whom there is substantial evidence supporting the use of this treatment. [26][27][28]33 The evidence supports a recommendation of CFTR modulators for the management of CF CRS. Pulmonologists with experience in CF generally prescribe and manage these novel pharmacotherapies.…”

Necessary Factors for Efficient Frontal Sinus Irrigation After Endoscopic Sinus Surgery: A Systematic Review

“…Furthermore, a previous study demonstrated that the irrigation efficiency was volume-dependent. 50,51 The present study showed that squeeze bottles likely provided the best irrigation for the frontal sinus. 15,17,18,30 This advantage was related to high flow momentum during the effective squeeze, increasing penetration into the frontal sinus.…”

“…However, some human studies suggested that the squeeze bottle may have some side effects, including Eustachian tube dysfunction. 50 , 51 It should be noted that the squeeze pressure of the squeeze bottle was adjustable. Appropriate squeeze pressure and patient selection can reduce the side effects.…”

Nasal saline irrigation: therapeutic or homeopathic

“…In 2007, a Cochrane review on nasal saline therapy demonstrated a large shift in symptom improvement on meta-analysis of randomized controlled trials, with a 1.41 standardized mean difference (SMD) in favor of saline therapy. 2 This represents an improvement of 1.41 standard deviations on the symptom scale compared to placebo and compares favorably to the treatment effect observed in other sinonasal interventions with intranasal corticosteroids for CRS (SMD 0.49) and immunotherapy for AR (SMD 0.71). This large symptom effect underscores its growing popularity.…”

The management of cystic fibrosis chronic rhinosinusitis: An evidenced‐based review with recommendations

“…The use of saline irrigations is better studied in patients with non-CF CRS, in whom there is substantial evidence supporting the use of this treatment. [26][27][28]33 The evidence supports a recommendation of CFTR modulators for the management of CF CRS. Pulmonologists with experience in CF generally prescribe and manage these novel pharmacotherapies.…”

Necessary Factors for Efficient Frontal Sinus Irrigation After Endoscopic Sinus Surgery: A Systematic Review

“…Furthermore, a previous study demonstrated that the irrigation efficiency was volume-dependent. 50,51 The present study showed that squeeze bottles likely provided the best irrigation for the frontal sinus. 15,17,18,30 This advantage was related to high flow momentum during the effective squeeze, increasing penetration into the frontal sinus.…”

“…However, some human studies suggested that the squeeze bottle may have some side effects, including Eustachian tube dysfunction. 50 , 51 It should be noted that the squeeze pressure of the squeeze bottle was adjustable. Appropriate squeeze pressure and patient selection can reduce the side effects.…”

Nasal saline irrigation: therapeutic or homeopathic

“…In 2007, a Cochrane review on nasal saline therapy demonstrated a large shift in symptom improvement on meta-analysis of randomized controlled trials, with a 1.41 standardized mean difference (SMD) in favor of saline therapy. 2 This represents an improvement of 1.41 standard deviations on the symptom scale compared to placebo and compares favorably to the treatment effect observed in other sinonasal interventions with intranasal corticosteroids for CRS (SMD 0.49) and immunotherapy for AR (SMD 0.71). This large symptom effect underscores its growing popularity.…”

The management of cystic fibrosis chronic rhinosinusitis: An evidenced‐based review with recommendations

“…The use of saline irrigations is better studied in patients with non-CF CRS, in whom there is substantial evidence supporting the use of this treatment. [26][27][28]33 The evidence supports a recommendation of CFTR modulators for the management of CF CRS. Pulmonologists with experience in CF generally prescribe and manage these novel pharmacotherapies.…”

Necessary Factors for Efficient Frontal Sinus Irrigation After Endoscopic Sinus Surgery: A Systematic Review

“…Furthermore, a previous study demonstrated that the irrigation efficiency was volume-dependent. 50,51 The present study showed that squeeze bottles likely provided the best irrigation for the frontal sinus. 15,17,18,30 This advantage was related to high flow momentum during the effective squeeze, increasing penetration into the frontal sinus.…”

“…However, some human studies suggested that the squeeze bottle may have some side effects, including Eustachian tube dysfunction. 50 , 51 It should be noted that the squeeze pressure of the squeeze bottle was adjustable. Appropriate squeeze pressure and patient selection can reduce the side effects.…”