Nasal saline irrigation: therapeutic or homeopathic

Barham, Henry P.; Harvey, Richard J.

doi:10.1016/j.bjorl.2015.07.002

Cited by 19 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It can be used in allergic or nonallergic rhinitis, postoperative care of endoscopic sinus surgery or septal surgery, and atrophic rhinitis [2,3]. Nasal irrigation works by mechanically removing inflammatory mucin and therefore enhancing mucociliary function [4].…”

Section: Introductionmentioning

confidence: 99%

Mupirocin in the Treatment of Staphylococcal Infections in Chronic Rhinosinusitis: A Meta-Analysis

Kim

Kwon

2016

PLoS ONE

View full text Add to dashboard Cite

BackgroundSaline irrigation of the nasal cavity is a classic and effective treatment for acute or chronic rhinosinusitis. Topical antibiotics such as mupirocin have been widely used for recalcitrant chronic rhinosinusitis. Therefore, the purpose of this study was to evaluate the effect of saline irrigation using mupirocin.MethodsA systematic literature review and meta-analysis of mupirocin saline irrigation were performed using EMBASE, MEDLINE, and Cochrane library through December 2015. Data were analyzed with R 3.2.2 software. A random effects model was used because of the diversity of included studies. Sensitivity analysis of particular tested groups and single proportion tests were also performed. The main outcome measure was residual staphylococcal infection, as confirmed by culture or PCR.ResultsTwo RCTs, two prospective studies and two retrospective studies were included. A random effects model meta-analysis of the pooled data identified a relative risk of residual infection of 0.13 (95% CI: 0.06–0.26, p<0.05) with low heterogeneity (I2 = 0%). The proportion of residual staphylococcal infections after 1 month was 0.08 (95% CI: 0.04–0.16). However, this proportion increased to 0.53 at 6 months (95% CI: 0.27–0.78).ConclusionsThe short-term use of mupirocin has a strongly reductive effect on staphylococcal infection in chronic rhinosinusitis. Although there is currently a lack of clear evidence, future studies with well-designed inclusion criteria and randomized controlled trials are needed to examine mupirocin’s long-term effect on chronic rhinosinusitis.

show abstract

Section: Introductionmentioning

confidence: 99%

Mupirocin in the Treatment of Staphylococcal Infections in Chronic Rhinosinusitis: A Meta-Analysis

Kim

Kwon

2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Higher IL-5, eotaxin, MIP-1α, and IL-17 levels have been found in the nasal fluid of patients with seasonal AR [24]. Irrigation with saline may remove the inflammatory mediators and decrease the subsequent inflammatory cascades of AR [25,26,27]. Moreover, irrigation may remove sticky secretions and restore the muco-ciliary function [28,29,30,31,32].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Hypertonic Saline Nasal Irrigation for Alleviating Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis

Lin

et al. 2019

JCM

View full text Add to dashboard Cite

We aimed to explore the efficacy of hypertonic saline nasal irritation (HSNI) for improving nasal symptoms and quality of life, and for decreasing oral antihistamine consumption in children with allergic rhinitis (AR). We conducted a systematic search of PubMed, Medline, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Chinese Electronic Periodicals Service, and Cochrane Library of Controlled Trials databases for prospective randomized, controlled trials assessing HSNI effects in children with AR and published before December 2017. Two authors independently assessed each trial’s quality and extracted data for a meta-analysis. We included four trails comprising 351 patients. HSNI improved patients’ nasal symptom scores (mean difference 1.82 points after treatment; 95% confidence interval (CI), 0.35–3.30; I2 = 64%; p = 0.02) and a significantly lower rescue antihistamine use rate (risk ratio (RR), 0.68; 95% CI, 0.48–0.95; I2 = 28%; p = 0.02). Analyses comparing HSNI with isotonic saline nasal irrigation (ISNI) showed better nasal symptom scores (mean difference, 1.22 points; 95% CI, 1.01–1.44; I2 = 0%; p < 0.001) in patients in the HSNI group, although the antihistamine use (RR, 0.84; 95% CI, 0.64–1.10; I2 = 0%; p = 0.2) and adverse effect rates were similar between groups. Compared with ISNI, HSNI may be a reasonable adjunctive treatment for children with AR.

show abstract

“…They are more common (10–20% of the cases) when very high volume devices are used. However, because they are mild in most of the cases, compliance is high [40]. Attention should be paid to the temperature of the solution because solutions that are either too cold or too hot can cause problems of tolerance.…”

Section: Tolerability and Safety Of Nasal Irrigation (Ni)mentioning

confidence: 99%

Nasal Irrigation: An Imprecisely Defined Medical Procedure

Principi

Esposito

2017

IJERPH

View full text Add to dashboard Cite

Nasal irrigation (NI) is an old practice of upper respiratory tract care that likely originated in the Ayurvedic medical tradition. It is used alone or in association with other therapies in several conditions—including chronic rhinosinusitis and allergic rhinitis—and to treat and prevent upper respiratory tract infections, especially in children. However, despite it being largely prescribed in everyday clinical practice, NI is not included or is only briefly mentioned by experts in the guidelines for treatment of upper respiratory tract diseases. In this review, present knowledge about NI and its relevance in clinical practice is discussed to assist physicians in understanding the available evidence and the potential use of this medical intervention. Analysis of the literature showed that NI seems to be effective in the treatment of several acute and chronic sinonasal conditions. However, although in recent years several new studies have been performed, most of the studies that have evaluated NI have relevant methodologic problems. Only multicenter studies enrolling a great number of subjects can solve the problem of the real relevance of NI, and these studies are urgently needed. Methods for performing NI have to be standardized to determine which solutions, devices and durations of treatment are adequate to obtain favorable results. This seems particularly important for children that suffer a great number of sinonasal problems and might benefit significantly from an inexpensive and simple preventive and therapeutic measure such as NI.

show abstract

Nasal saline irrigation: therapeutic or homeopathic

Cited by 19 publications

References 7 publications

Mupirocin in the Treatment of Staphylococcal Infections in Chronic Rhinosinusitis: A Meta-Analysis

Mupirocin in the Treatment of Staphylococcal Infections in Chronic Rhinosinusitis: A Meta-Analysis

Effectiveness of Hypertonic Saline Nasal Irrigation for Alleviating Allergic Rhinitis in Children: A Systematic Review and Meta-Analysis

Nasal Irrigation: An Imprecisely Defined Medical Procedure

Contact Info

Product

Resources

About