Nasal polyposis: Role of subclinical delayed food hypersensitivity

Pang, Yan; Eskici, O.; Wilson, Janet A.

doi:10.1016/s0194-5998(00)70259-2

Cited by 40 publications

(48 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NP is known to be associated with bronchial asthma and a number of topical and systemic diseases of different origins (11)(12)(13). The exact origin of NP is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The exact origin of NP is unknown. However, a variety of allergic, infectious, inflammatory, anatomic, and genetic factors are known to be involved as are autonomous dysfunction and ciliary, enzymatic, epithelial, and mucopolysaccharide abnormalities (12,13). No single pathogenic factor has been shown to apply to all types of polyps, although the potential mechanisms may converge on a single pathway.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Modification of the maxillary bone in adults with nasal polyposis: a CT morphometric study

Serter

Günhan²,

Can³

et al. 2009

Diagn Interv Radiol

View full text Add to dashboard Cite

Chronic nasal obstruction is a common complaint in otorhinolaryngology outpatient practice (1, 2). Causes of nasal obstruction, conditioning mouth breathing, include nasoseptal deviation, hypertrophied lower turbinates, adenoids and tonsils, chronic or especially allergic rhinitis, nasal trauma, congenital nasal deformities, foreign bodies, nasal polyps, and tumors (3). One of the most common causes of nasal obstruction in adults is nasal polyposis (NP) (1, 2). Computed tomography (CT) is the ideal imaging method to investigate nasal and paranasal sinus diseases (4, 5).In paranasal sinus CT scans, we have recently observed that the plane angle between the maxillary alveolar process (MAP) and palatine bone (PB) is increased and the depth of maxillary arch is decreased in many cases with NP.Pediatric orthodontics literature concerning how nasal obstruction relates to dentofacial development is extensive and whether a cause-effect relationship exists has been debated for over a century (6)(7)(8). Although recent studies suggest a relationship between chronic nasal obstruction and dentofacial deformities, many questions remain unanswered (9, 10). However, there is very limited data on the morphometry of the maxillary arch in adults with nasal obstruction.The objectives of the present study are to correlate the airway variables obtained by paranasal sinus CT findings of both patients with chronic nasal airway obstruction and a control group in adult population, and to investigate whether the bony structure of the airway is affected or not. Materials and methodsForty NP cases that were followed up by an otorhinolaryngologist at least for 1 year were included in this retrospective study. The control group consisted of 40 subjects that were randomly selected from our CT database. Control subjects had normal findings or trivial pathologies, which did not cause any nasal airway obstruction (e.g., minimal mucosal thickening, small retention cyst) reported in paranasal CT scans. Both groups were similar regarding the age and weight. The diagnosis of NP was established by direct visualization via nasal endoscopy.Paranasal sinus CT scans of all subjects were performed with the same parameters. A single slice spiral unit (Siemens Emotion, Siemens, Erlangen, Germany) was used for imaging. Unenhanced, 3 mm thick coronal and axial contiguous slices (pitch, 1.5) were obtained in the prone position with the head hyperextended. Although images were originally obtained with soft tissue and bone windows, we made the calculations on a single set of images obtained in the bone algorithm (window width, 2000-3000; window level, 400-760). The maxillary and palatine bones were evaluated on coronal images. The plane angle between MAP and There is yet no study in the literature measuring the morphometry of maxillary bone in NP. The objectives of this study are to correlate the airway variables obtained by CT findings of both chronic nasal airway obstruction and control group in an adult population, and to investigate whether the bony structur...

show abstract

“…NP is known to be associated with bronchial asthma and a number of topical and systemic diseases of different origins (11)(12)(13). The exact origin of NP is unknown.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Modification of the maxillary bone in adults with nasal polyposis: a CT morphometric study

Serter

Günhan²,

Can³

et al. 2009

Diagn Interv Radiol

View full text Add to dashboard Cite

show abstract

“…A few studies show higher sensitization rates to foods in patients with CRSwNP compared to controls, but the clinical implications are not known. 892,893 Despite an overlap of immunologic pathways and of symptoms, conflicting data in the literature prevents definitive conclusion about the association between atopy and nasal polyposis. Well-designed, prospective studies with defined inclusion and exclusion criteria among defined populations should shed additional light on this relationship.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

“…Si bien en los últimos años se ha retomado y profundizado el estudio de la hipersensibilidad a distintos alergenos (incluidos hongos y alimentos) en pacientes con poliposis nasosinusal [15][16][17] no existen datos clínicos ni epidemiológicos al respecto en nuestro país. Esta situación se ve favorecida por la ausencia habitual de alergenos fúngicos que pudieran ser relevantes en esta patología, en los exámenes alergológicos de rutina.…”

Section: Introductionunclassified

Diferencias en la sensibilización a aeroalergenos en pacientes con poliposis nasosinusal

et al. 2009

Rev. Otorrinolaringol. Cir. Cabeza Cuello

View full text Add to dashboard Cite

RESUMENIntroducción: La poliposis nasosinusal (PN) es una enfermedad inflamatoria crónica de la mucosa. Apoyado en los hallazgos clínicos, histológicos e inmunológicos, se postula a la alergia como un factor etiopatogénico, lo cual no ha sido plenamente demostrado.Objetivo: Evaluar la presencia de hipersensibilidad a aeroalergenos en pacientes con PN y compararla con pacientes normales.Material y método: Se realizó prick test a aeroalergenos a todos los pacientes utilizando 30 alergenos frecuentes en el área metropolitana de Santiago, incluyendo pólenes de árboles, malezas y pastos, ácaros, epitelio de animales y hongos habituales. Este test se amplió con el uso de tres hongos habitualmente no evaluados (Stemphyllium, Pullularia, Helminthosporium). Se utilizó la prueba de Chi cuadrado con una significancia de 0,05.Resultados: El 71% de los pacientes con PN (n =73) y el 66% del grupo control (n =44) presentaban un test cutáneo positivo, sin diferencia estadística significativa. El patrón de sensibilización a aeroalergenos fue similar, salvo para los alergenos fúngicos: los pacientes con PN estaban sensibilizados en 40% a Pullularia, 30% a Stemphyllium, y 10% a Helminthosporium. En tanto que los controles no presentaron sensibilización a estos hongos no habituales.Discusión y conclusiones: Existe una alta tasa de sensibilización a aeroalergenos en pacientes normales y con PN, lo que sugiere un probable rol de la alergia en la patogénesis de la poliposis nasal. Destaca un patrón diferente de sensibilización a alergenos fúngicos, cuya relevancia clínica debe ser evaluada a futuro.Palabras clave: Poliposis nasal, hipersensibilidad, hongos. ABSTRACTIntroduction: Nasal polyposis (NP) is a chronic inflammatory disease that leads to tissue oedema and eventually polyps. The pathogenesis of NP has not been fully understood yet, but there are clinical, histological, and immunological findings that suggest that allergy plays a role.

show abstract

Nasal polyposis: Role of subclinical delayed food hypersensitivity

Cited by 40 publications

References 13 publications

Modification of the maxillary bone in adults with nasal polyposis: a CT morphometric study

Modification of the maxillary bone in adults with nasal polyposis: a CT morphometric study

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Diferencias en la sensibilización a aeroalergenos en pacientes con poliposis nasosinusal

Contact Info

Product

Resources

About