Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet activating factor: Different degrees of responsiveness in atopic and nonatopic subjects*

Local and systemic proteolytic responses in chronic rhinosinusitis with nasal polyposis and asthma

“…This is consistent with the earlier results in CRSwNP and asthma . Atopic patients have been shown to exhibit faster and stronger neutrophil activation in the nasal cavity . Could atopy then be the sole explanation for the elevated nasal MMP and MPO levels detected in the control group; ie, when SPT+ and SPT− subjects were evaluated as one group?…”

An update on the diagnosis and treatment of sinusitis and nasal polyposis

“…Today, little is known about the interaction between the microorganisms and the mucous lining of the paranasal sinuses in terms of neutrophilic chemotaxis induction. In healthy people, more neutrophil granulocytes were found in nasal irrigation fluid (35%) than in the tissue itself (26, 33, 34). The continuous influx of neutrophil granulocytes is attributed to the chemotactic effect of IL‐8, which is constitutively synthesized by epithelial cells, glandular cells and leukocytes (31, 35–38).…”

Avaliação da inflamação das vias aéreas. Vias áreas superiores e compartimento broncopulmonar

“…Embora esta avaliação não permita localizar o processo inflamatório quando analisado num contexto clínico específico, poderá fornecer informação fidedigna sobre a inflamação do órgão onde ocorreram as manifestações clínicas 20,21 . 36,37,38 .…”