Nasal Mucociliary Clearance in Subjects With COPD After Smoking Cessation

Ito, Juliana Tiyaki; Ramos, Dionei; Lima, Fernando Parra dos Anjos; Rodrigues, Fernanda; Gomes, Paulo R.; Moreira, Graciane Laender; Macchione, Mariângela; Toledo, Alessandra Choqueta de; Ramos, Ercy Mara Cípulo

doi:10.4187/respcare.03266

Cited by 18 publications

(10 citation statements)

References 59 publications

(63 reference statements)

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“…So far, this parameter has not been affected by interventions expected to improve COPD disability such as aerobic training [75] or inhaled tiotropium [76]. The mucociliary clearance was improved after smoking cessation at nasal level only [77].…”

Section: Functional Assessment Of Small Airwaysmentioning

confidence: 99%

COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is characterised by nonreversible proximal bronchial obstruction leading to major respiratory disability. However, patient phenotypes better capture the heterogeneously reported complaints and symptoms of COPD. Recent studies provided evidence that classical bronchial obstruction does not properly reflect respiratory disability, and symptoms now form the new paradigm for assessment of disease severity and guidance of therapeutic strategies. The aim of this review was to explore pathways addressing COPD pathogenesis beyond proximal bronchial obstruction and to highlight innovative and promising tools for phenotyping and bedside assessment. Distal small airways imaging allows quantitative characterisation of emphysema and functional air trapping. Micro-computed tomography and parametric response mapping suggest small airways disease precedes emphysema destruction. Small airways can be assessed functionally using nitrogen washout, probing ventilation at conductive or acinar levels, and forced oscillation technique. These tests may better correlate with respiratory symptoms and may well capture bronchodilation effects beyond proximal obstruction.Knowledge of inflammation-based processes has not provided well-identified targets so far, and eosinophils probably play a minor role. Adaptative immunity or specific small airways secretory protein may provide new therapeutic targets. Pulmonary vasculature is involved in emphysema through capillary loss, microvascular lesions or hypoxia-induced remodelling, thereby impacting respiratory disability.

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Section: Functional Assessment Of Small Airwaysmentioning

confidence: 99%

COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside

et al. 2019

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“…These results in vivo 34: 845-848 (2020) 846 suggest an increased risk of pneumonia due to impaired mucociliary clearance in nursing home residents. Dehydration (15), history of smoking (16,17), chronic obstructive pulmonary disease (COPD) (18), chronic sinusitis (19), sinobronchial syndrome (20), and gastroesophageal reflux disease (21) have been reported as factors associated with a prolonged ST. While individuals presenting these factors were excluded from the adult group in the present study, those with smoking habits, COPD may have been included in the elderly group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Saccharin Time in Nursing Home Residents With and Without Pneumonia: A Preliminary Study

Uchida

Nohara

Tanaka

et al. 2020

In Vivo

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“…The technique for measuring nasal MC has been described elswhere 9,14,15 . In brief, granulated sodium saccharin (250 μg) was deposited under visual control about 2 cm inside the right nostril.…”

Section: Methodsmentioning

confidence: 99%

Função pulmonar e depuração mucociliar nasal de cortadores de cana-de-açúcar brasileiros expostos à queima de biomassa

Ferreira¹,

Ramos

Trevisan

et al. 2018

Rev. bras. saúde ocup.

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Nasal Mucociliary Clearance in Subjects With COPD After Smoking Cessation

Cited by 18 publications

References 59 publications

COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside

COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside

Comparison of Saccharin Time in Nursing Home Residents With and Without Pneumonia: A Preliminary Study

Função pulmonar e depuração mucociliar nasal de cortadores de cana-de-açúcar brasileiros expostos à queima de biomassa

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