Nasal Melanophoroma in a Captive Green Iguana (Iguana Iguana)

Macêdo, Isabel Luana de; Sousa, Davi Emanuel Ribeiro de; Hirano, Líria Queiroz Luz; Name, Khesller Patrícia Olázia; Báo, Sônia Nair; Castro, Márcio Botelho de

doi:10.1016/j.tcam.2020.100463

Cited by 2 publications

(6 citation statements)

References 9 publications

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“…While histologic examination is typically adequate to reach a diagnosis, IHC can be helpful for diagnosing poorly pigmented or amelanotic cases [ 13 , 17 ]. Reports of IHC effectiveness varies among studies and species, emphasizing the need for validation of IHC markers in reptilian species [ 9 , 12 , 13 , 16 , 17 , 39 , 40 , 41 , 42 , 44 , 45 ]. Transmission electron microscopy can be used to definitely identify the chromatophore type based on visualization of pigment structures or platelets.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis is fairly uncommon, but has been reported, with the most commonly affected organs being lungs, livers, kidneys, intestine, and fat bodies [ 8 , 9 , 40 ]. In the family Iguanidae (green iguanas), there have been reports of metastasis [ 8 , 36 , 37 , 44 ]. In the family Eublepharidae (leopard geckos), malignant iridophoromas are most common with occasional metastasis being described [ 8 , 9 , 25 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemistry (IHC) can be helpful to diagnose amelanotic or non-pigmented chromatophoromas [ 13 , 17 ]. Reported IHC results conflict depending on the study, but overall, antibodies utilized to detect mammalian melanocytes do not appear to have the same sensitivity and specificity for detecting reptilian chromatophoromas compared to their mammalian counterparts [ 9 , 12 , 13 , 16 , 17 , 39 , 40 , 41 , 42 , 44 , 45 ]. MelanA and S-100 have been shown to be most consistently expressed in a number of chromatophoromas in reptiles.…”

Section: Diagnosismentioning

confidence: 99%

“…In human melanomas, HBM45 has a relatively high specificity, but low sensitivity [ 49 ]. In cases of reptile chromatophoromas where IHC was performed, 84 out of 95 cases had immunoreactivity for S-100; 31 out of 90 cases had immunoreactivity for MelanA; 8 out of 60 cases had immunoreactivity for PNL2; and 2 out of 43 cases had immunoreactivity for HMB45 [ 9 , 12 , 13 , 16 , 17 , 39 , 40 , 41 , 42 , 44 , 45 ]. Immunohistochemistry does not appear to be helpful to differentiate the different types of chromatophoromas.…”

Section: Diagnosismentioning

confidence: 99%

“…Chromatophoromas have been described in green iguanas ( Iguana iguana ) [ 8 , 36 , 37 , 44 ] ( Table 2 ). A search for “chromatophoromas, melanoma, melanophoromas, iridophoromas, and xanthophoromas” of the archives of Northwest ZooPath revealed no additional affected species.…”

Section: Chromatophoromas In Lacertillamentioning

confidence: 99%

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Chromatophoromas in Reptiles

Monahan

Garner²,

Kiupel

2022

Veterinary Sciences

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Chromatophoromas are neoplasms that arise from pigment cells of reptiles, amphibians, and fish. They include melanophoromas (melanomas), iridophoromas, and xanthophoromas. Most chromatophoromas develop spontaneously, but genetic and environmental factors may also play a role in their oncogenesis. The diagnosis is typically through histologic examination. Immunohistochemistry and electron microscopy can be helpful for diagnosing poorly differentiated and/or poorly pigmented neoplasms. Aggressive surgical excision is the current treatment of choice. This review describes the clinical presentation, gross appearance, diagnostic applications, clinical behavior, and treatment of chromatophoromas in reptiles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Chromatophoromas In Lacertillamentioning

confidence: 99%

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Chromatophoromas in Reptiles

Monahan

Garner²,

Kiupel

2022

Veterinary Sciences

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Melanophoroma in a Lichtenstein's green racer snake

Beanes,

dos Passos,

Cavalcanti

et al. 2023

Veterinary Clinical Pathol

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Melanophoroma is a neoplasm of reptilian pigment cells, considered uncommon and part of a group of neoplasms called chromatophoromas. The objective of this work was to describe a case of melanophoroma in a free‐living Lichtenstein's green racer snake (Philodryas olfersii), presenting with an ulcerative nodular neoformation in the integument of the head region. In the neurologic evaluation, a proprioceptive deficit was observed. Ultrasound, X‐ray, and mass cytology examinations were performed. Radiographic and ultrasound findings of the tumor indicated infiltrative behavior, and cytology indicated a presumptive diagnosis of a melanocytic neoplasm. Based on the results of the examinations and the patient's clinical condition, euthanasia was chosen. At necropsy, there was a nodule measuring 4.5 × 2.5 × 2.0 cm, with a blackish‐colored cut surface, mottled by gray areas, which infiltrated soft tissue and bone, and extended dorsally from the mouth to the cervical musculature. On microscopy, a non‐delimited, non‐encapsulated, and invasive neoplastic proliferation was observed, with moderate cellularity, which was predominantly composed of fusiform cells with distinct borders and foci of epithelioid cells. The cells had ample cytoplasm, which had a brown to black (melanocytic) granular pigment compatible with a melanophoroma. To the best of the authors' knowledge, this is a unique description of a melanophoroma in P. olfersii.

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Nasal Melanophoroma in a Captive Green Iguana (Iguana Iguana)

Cited by 2 publications

References 9 publications

Chromatophoromas in Reptiles

Chromatophoromas in Reptiles

Melanophoroma in a Lichtenstein's green racer snake

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