Chromatophoromas in Reptiles

Monahan, Colleen F; Garner, Michael M.; Kiupel, Matti

doi:10.3390/vetsci9030115

Cited by 5 publications

(2 citation statements)

References 49 publications

(371 reference statements)

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“…The increasing number of neoplastic disorders that are being diagnosed in captive reptiles can at least be partly attributed to the fact that reptile owners more readily seek veterinary advice as well as to the increasing availability and use of appropriate diagnostic tools. In addition, the increasing lifespan of reptile pets as well as predisposing environmental and genetic factors may also contribute to the seemingly increasing prevalence of neoplastic disorders [ 3 , 5 , 6 , 8 , 9 , 10 ]. Nevertheless, the diagnosis of neoplasms in reptile patients can easily be missed at initial presentation as associated clinical signs are often non-specific [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Histological Variants of Squamous and Basal Cell Carcinoma in Squamates and Chelonians: A Comprehensive Classification

Vilanova

Hellebuyck

Chiers

2023

Animals

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In the present study, the histological characteristics of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) obtained from 22 squamate and 13 chelonian species were retrospectively evaluated. While the examined tissues were originally diagnosed as 28 SCCs and 7 BCCs based on histological evaluation by a specialty diagnostic service, eight SCCs could be re-classified as BCCs and three SCCs proved to be non-neoplastic lesions. In addition, all SCCs and BCCs were classified into distinct histological variants. The SCCs could be categorized as one SCC in situ, three moderately differentiated SCCs, seven well-differentiated SCCs, and six keratoacanthomas. BCCs were classified as five solid BCCs, four infiltrating BCCs, five keratotic BCCs, and one basosquamous cell carcinoma. In addition, the present study reports the occurrence of BCCs in seven reptile species for the first time. In contrast to what has been documented in humans, IHC staining with the commercially available epithelial membrane antigen and epithelial antigen clone Ber-EP4 does not allow differentiation of SCCs from BCCs in reptiles, while cyclooxygenase-2 and E-cadherin staining seem to have discriminating potential. Although the gross pathological features of the examined SCCs and BCCs were highly similar, each tumor could be unequivocally assigned to a distinct histological variant according to the observed histological characteristics. Based on the results of this study, a histopathological classification for SCCs and BCCs is proposed, allowing accurate identification and differentiation of SCCs and BCCs and their histological variants in the examined reptile species. Presumably, BCCs are severely underdiagnosed in squamates and chelonians.

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Section: Introductionmentioning

confidence: 99%

Histological Variants of Squamous and Basal Cell Carcinoma in Squamates and Chelonians: A Comprehensive Classification

Vilanova

Hellebuyck

Chiers

2023

Animals

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“…Chromatophoromas are a group of neoplasms arising from pigment-bearing cells (chromatophores) in the skin of reptiles and include melanophoromas (melanomas), iridophoromas, and xanthophoromas. The review by Monahan and colleagues comprehensively catalogues the occurrence and aetiology of chromatophoromas in the different species of reptiles (lizards, snakes and turtles), as well as providing clinical perspectives on their diagnosis (gross appearance, cytology, histology, immunohistochemistry and electron microscopy), staging and treatment [ 4 ]. Melanocytic neoplasms in dogs occur at a range of sites and display a variety of biological behaviours, from benign melanocytomas to malignant melanomas with high metastatic propensity, posing both a diagnostic and prognostic challenge.…”

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confidence: 99%

Advances in Understanding Spontaneously Occurring Melanoma in Animals

Blacklock

Weyden

2023

Veterinary Sciences

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When pink is a question: Comparative gross and microscopic skin structure analyses reveal the histological basis of skin colour in Galápagos pink land iguanas (Conolophus marthae)

Lewbart,

Colosimo,

Gaudette

et al. 2023

Acta Zoologica

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One of the rarest and most unusual iguanas on the planet is the Galápagos pink land iguana (Conolophus marthae). There have been a number of hypotheses on the source of their pink coloration, including that the colour is from blood and a relative lack of dermal pigmentation. We obtained full thickness skin biopsies of three species and compared tissue from darkly pigmented areas and lightly pigmented surfaces. “Pink” areas of pink iguanas are devoid of pigment cells (e.g. melanophores) and the dermal tissue is rich with aggregates of confluent capillaries. This was in sharp contrast to the minimally vascular (only capillaries were observed) dermal areas of the marine and yellow iguanas. The dermal stratum laxum of every biopsy site contained melanophores except for the pink skin of pink iguanas. Interestingly, marine iguanas have a much thicker epidermal stratum germinativum/granulosum, between 2 and 10 cells thick depending on location, compared to the thinner epidermal stratum germinativum/granulosum of land iguanas (one to three cells thick with most areas possessing just one or two cell layers). These microscopic differences might reflect differences in habitat and ecology of the three species.

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Chromatophoromas in Reptiles

Cited by 5 publications

References 49 publications

Histological Variants of Squamous and Basal Cell Carcinoma in Squamates and Chelonians: A Comprehensive Classification

Histological Variants of Squamous and Basal Cell Carcinoma in Squamates and Chelonians: A Comprehensive Classification

Advances in Understanding Spontaneously Occurring Melanoma in Animals

When pink is a question: Comparative gross and microscopic skin structure analyses reveal the histological basis of skin colour in Galápagos pink land iguanas (Conolophus marthae)

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