Nasal Inserts for Drug Delivery: An Overview

Algin-Yapar, E

doi:10.4314/tjpr.v13i3.22

Cited by 8 publications

(1 citation statement)

References 49 publications

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“…The mechanism of action is similar for NSPAHs and carrageenans and may be attributed to the inhibition of virus release from infected cells. Further, even though NSPAHs show efficacies similar to those of carrageenans, these newly developed anti-influenza compounds present far better physicochemical properties, such as high solubility and lack of gelling properties (18,49).…”

Section: Discussionmentioning

confidence: 99%

Novel Polyanions Inhibiting Replication of Influenza Viruses

Ciejka

Milewska

Wytrwał-Sarna

et al. 2016

Antimicrob Agents Chemother

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Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized, and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NSPAHs were found to be nontoxic and very soluble in water, in contrast to gel-forming and thus generally poorly soluble carrageenans. In vitro and ex vivo studies using susceptible cells (Madin-Darby canine kidney epithelial cells and fully differentiated human airway epithelial cultures) demonstrated the antiviral effectiveness of NSPAHs. The activity of NSPAHs was proportional to the molecular mass of the chain and the degree of substitution of amino groups with sulfonate groups. Mechanistic studies showed that the NSPAHs and carrageenans inhibit influenza A and B virus assembly in the cell.

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Section: Discussionmentioning

confidence: 99%