Controlled Drug Delivery via the Nasal Route

Conway, Barbara R.; Ghori, Muhammad Usman

doi:10.1002/9781119769644.ch16

Cited by 3 publications

(2 citation statements)

References 148 publications

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“…However, there is currently insufficient information available to define which constituents represent an inhalational risk. Furthermore, molecules and drugs can be absorbed through the olfactory epithelium and its membranes and enter the bloodstream ( Kristensson and Olsson, 1971 ; Conway and Ghori, 2022 ). In addition, EOs can bind and modulate receptor proteins of the olfactory bulbs which can directly transmit signals via synapsis to electrochemical nerves and to the brain ( Angelucci et al, 2014 ).…”

Section: Therapeutic Uses Of Eosmentioning

confidence: 99%

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

et al. 2022

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Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands of years. They are widely used as fragrances in perfumes and cosmetics and contribute to a healthy diet, but also act as active ingredients of pharmaceutical products. Their antibacterial, antiviral, and anti-inflammatory properties have qualified EOs early on for both, the causal and symptomatic therapy of a number of diseases, but also for prevention. Obtained from natural, mostly plant materials, EOs constitute a typical example of a multicomponent mixture (more than one constituent substances, MOCS) with up to several hundreds of individual compounds, which in a sophisticated composition make up the property of a particular complete EO. The integrative use of EOs as MOCS will play a major role in human and veterinary medicine now and in the future and is already widely used in some cases, e.g., in aromatherapy for the treatment of psychosomatic complaints, for inhalation in the treatment of respiratory diseases, or topically administered to manage adverse skin diseases. The diversity of molecules with different functionalities exhibits a broad range of multiple physical and chemical properties, which are the base of their multi-target activity as opposed to single isolated compounds. Whether and how such a broad-spectrum effect is reflected in natural mixtures and which kind of pharmacological potential they provide will be considered in the context of ONE Health in more detail in this review.

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Section: Therapeutic Uses Of Eosmentioning

confidence: 99%

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

et al. 2022

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“…Along with this, the sensitive nature of nasal mucosa creates local irritation if the drug is not isotonic and has different pH. 70 NLC are nanosized biocompatible carriers that can deeply penetrate nasal mucosa and show sustained drug release. With the ability to deliver the drug in the nasal mucosa, these carriers are frequently investigated to deliver the drug into the brain.…”

Section: Delivery Through Nasal Routementioning

confidence: 99%

An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes

Khan¹,

Sharma²,

Jain³

2022

Adv Pharm Bull

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Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as a biocompatible, non-toxic, and safe nano-drug delivery system as compared to polymeric or metallic nanoparticles. Due to its safety, stability, and high drug loading capacity compared to other lipid-based nanocarriers, NLC gained the attention of researchers to formulate safe and effective drug carriers. The ability to increase drug solubility and permeability while encapsulating the drug in a lipidic shell makes them an ideal carrier for drug delivery through difficult-to-achieve routes. Surface modification of NLC and the use of various additives result in drug targeting and increased residence time. With such qualities, NLCs can be used to treat a variety of diseases such as cancer, infections, neurodegenerative diseases, hypertension, diabetes, and pain management. This review focuses on the recent developments being made to deliver the drugs and genes through different routes via these nanocarriers. Here, we also discuss about historical background, structure, types of NLC and commonly employed techniques for manufacturing lipid-based nanocarriers.

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Nanomaterial-based delivery of vaccine through nasal route: Opportunities, challenges, advantages, and limitations

Kumar

Dogra²,

Mandal³

2022

Journal of Drug Delivery Science and Technology

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Controlled Drug Delivery via the Nasal Route

Cited by 3 publications

References 148 publications

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes

Nanomaterial-based delivery of vaccine through nasal route: Opportunities, challenges, advantages, and limitations

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