Nasal high-flow oxygen therapy in COVID-19 patients does not cause environmental surface contamination

Roca, Oriol; Pacheco, Andrés; Rodón, Jordi; Antón, Andrés; Vergara‐Alert, Júlia; Armadans, Lluı́s; Pumarola, Tomás; Campins, Magda; Ferrer, Ricard; Garrido, Virginia Rodríguez

doi:10.1016/j.jhin.2021.04.034

Cited by 6 publications

(4 citation statements)

References 6 publications

(3 reference statements)

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“…There were no significant differences in SARS-CoV-2 RNA copies on surfaces and room air between subjects with COVID-19 treated by HFNC versus invasive ventilation. 43,44 Notably, no viable virus was detected by cell culture assays, which agreed with Li and colleagues' findings among 9 subjects with COVID-19 treated by HFNC. 41 Beyond these in vivo and in vitro studies, Westafer and colleagues evaluated COVID-19 infection rates among clinical and non-clinical staff in their emergency department before and after implementing a respiratory protocol that involved using HFNC to treat patients with COVID-19.…”

Section: Oxygen Devices Including High-flow Nasal Cannulasupporting

confidence: 87%

“…Room air sampling plates were placed at distances of 0.4 m and 1.5 m from the subjects and no significant differences in bacterial counts were found between oxygen modalities. 42 Two groups of researchers (Lebreil et al 43 and Roca et al 44 ) measured the SARS-CoV-2 RNA copies on surfaces and in the room air of subjects with COVID-19 receiving HFNC compared to subjects receiving invasive mechanical ventilation. Invasive mechanical ventilation was considered to present the lowest possibility of environmental contamination because intubated subjects were breathing via the ventilator and their exhaled gas was filtered.…”

Section: Oxygen Devices Including High-flow Nasal Cannulamentioning

confidence: 99%

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Aerosol-Generating Procedures and Virus Transmission

Alolaiwat

Fink

et al. 2022

Respir Care

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During the early phase of the COVID-19 pandemic, many respiratory therapies were classified as aerosol-generating procedures. This categorization resulted in a broad range of clinical concerns and a shortage of essential medical resources for some patients. In the past 2 years, many studies have assessed the transmission risk posed by various respiratory care procedures. These studies are discussed in this narrative review, with recommendations for mitigating transmission risk based on the current evidence.

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Section: Oxygen Devices Including High-flow Nasal Cannulasupporting

confidence: 87%

Section: Oxygen Devices Including High-flow Nasal Cannulamentioning

confidence: 99%

Aerosol-Generating Procedures and Virus Transmission

Alolaiwat

Fink

et al. 2022

Respir Care

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“…Nasal and fecal swabs positive for SARS-CoV-2 as determined by RT-qPCR were evaluated for the presence of the infectious virus by titration in Vero E6 cells, as previously reported [ 21 , 28 ]. Direct samples and ten-fold dilutions were transferred to Vero E6 monolayers.…”

Section: Methodsmentioning

confidence: 99%

Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses

Fernández-Bellón

Rodón

Fernández‐Bastit

et al. 2021

Viruses

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To date, no evidence supports the fact that animals play a role in the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19). However, several animal species are naturally susceptible to SARS-CoV-2 infection. Besides pets (cats, dogs, Syrian hamsters, and ferrets) and farm animals (minks), different zoo animal species have tested positive for SARS-CoV-2 (large felids and non-human primates). After the summer of 2020, a second wave of SARS-CoV-2 infection occurred in Barcelona (Spain), reaching a peak of positive cases in November. During that period, four lions (Panthera leo) at the Barcelona Zoo and three caretakers developed respiratory signs and tested positive for the SARS-CoV-2 antigen. Lion infection was monitored for several weeks and nasal, fecal, saliva, and blood samples were taken at different time-points. SARS-CoV-2 RNA was detected in nasal samples from all studied lions and the viral RNA was detected up to two weeks after the initial viral positive test in three out of four animals. The SARS-CoV-2 genome was also detected in the feces of animals at different times. Virus isolation was successful only from respiratory samples of two lions at an early time-point. The four animals developed neutralizing antibodies after the infection that were detectable four months after the initial diagnosis. The partial SARS-CoV-2 genome sequence from one animal caretaker was identical to the sequences obtained from lions. Chronology of the events, the viral dynamics, and the genomic data support human-to-lion transmission as the origin of infection.

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“…Initially, concerns about the risk of HFNO spreading COVID-19 through aerosolization were expressed. However, recent evidence confirmed that HFNO poses a low risk of spread, and delivery with a surgical mask prevents aerosol dispersal ( 40 – 43 ).…”

Section: Clinical Efficacy Of High Flow Nasal Oxygenationmentioning

confidence: 99%

Recent advances in the use of high flow nasal oxygen therapies

Wyatt¹,

Goel

Whittle

2022

Front. Med.

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High flow nasal oxygen is a relatively new option for treating patients with respiratory failure, which decreases work of breathing, improves tidal volume, and modestly increases positive end expiratory pressure. Despite well-described physiologic benefits, the clinical impact of high flow nasal oxygen is still under investigation. In this article, we review the most recent findings on the clinical efficacy of high flow nasal oxygen in Type I, II, III, and IV respiratory failure within adult and pediatric patients. Additionally, we discuss studies across clinical settings, including emergency departments, intensive care units, outpatient, and procedural settings.

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Nasal high-flow oxygen therapy in COVID-19 patients does not cause environmental surface contamination

Cited by 6 publications

References 6 publications

Aerosol-Generating Procedures and Virus Transmission

Aerosol-Generating Procedures and Virus Transmission

Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses

Recent advances in the use of high flow nasal oxygen therapies

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