Nasal Colonization by Staphylococci and Severity of Atopic Dermatitis

Blicharz, Leszek; Usarek, Paulina; Młynarczyk, G.; Skowroński, Krzysztof; Rudnicka, Lidia; Samochocki, Zbigniew

doi:10.1097/der.0000000000000568

Cited by 12 publications

(14 citation statements)

References 34 publications

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“…Blicharz et al . [ 47 ] showed that adult patients with AD co-colonized with S . aureus and CoNS on the skin and anterior nares had lower IgE levels than those colonized only with S .…”

Section: Discussionmentioning

confidence: 99%

Skin and nasal colonization of coagulase-negative staphylococci are associated with atopic dermatitis among South African toddlers

et al. 2022

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Background Skin colonization with coagulase-negative staphylococci (CoNS) is generally beneficial, but recent investigations suggest its association with flares and atopic dermatitis (AD) severity. However, this relationship remains unclear. Objective To assess patterns of staphylococcal colonization and biofilm formation in toddlers with and without AD from rural and urban South African settings. Methods We conducted a cross-sectional study of AD-affected and non-atopic AmaXhosa toddlers from rural Umtata and urban Cape Town, South Africa. CoNS isolates were recovered from lesional, nonlesional skin samples and the anterior nares of participants. Identification of the staphylococci was achieved by MALDI-TOF mass spectrometry. The microtiter plate assay assessed in-vitro biofilm formation. Results CoNS and S. aureus commonly co-colonized nonlesional skin among cases (urban: 24% vs. 3%, p = 0.037 and rural 21% vs. 6%, p<0.001), and anterior nares in urban cases (24% vs. 0%, p = 0.002) than the control group. S. capitis colonization on nonlesional skin and anterior nares was positively associated with more severe disease in rural (48.3±10.8 vs. 39.7±11.5, P = 0.045) and urban cases (74.9±10.3 vs. 38.4±13, P = 0.004), respectively. Biofilm formation was similar between cases and controls, independent of rural-urban living. Conclusion CoNS colonization is associated with AD and disease severity and may be implicated in AD exacerbations. Studies are needed to understand their underlying pathological contribution in AD pathogenesis.

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“…Blicharz et al . [ 47 ] showed that adult patients with AD co-colonized with S . aureus and CoNS on the skin and anterior nares had lower IgE levels than those colonized only with S .…”

Section: Discussionmentioning

confidence: 99%

Skin and nasal colonization of coagulase-negative staphylococci are associated with atopic dermatitis among South African toddlers

et al. 2022

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“…To date, biofilm studies concerning S. aureus in AD have been predominantly based on isolates from the skin, generally concluding that the ability to form biofilm associates with more severe AD and that the extent of biofilm formation positively correlates with the intensity of the lesions [12, 16-18]. However, S. aureus is also frequently isolated from the anterior nares, which could be a potential source of this pathogen in AD [13, 19].…”

Section: Discussionmentioning

confidence: 99%

“…In the previous study [13], we showed that the abundance of S. aureus not only on the skin but also in the anterior nares correlates with the severity of AD. It seems possible that the anterior nares, aside from the skin, are an important niche to be investigated for the carriage and characteristics of S. aureus to better understand the nature and impact of microbiome disorders in AD.…”

Section: Introductionmentioning

confidence: 88%

The Propensity to Form Biofilm in vitro by Staphylococcus aureus Strains Isolated from the Anterior Nares of Patients with Atopic Dermatitis: Clinical Associations

et al. 2020

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Background: Atopic dermatitis is a chronic inflammatory dermatosis with complex pathogenesis. The skin microbiome in atopic dermatitis is dominated by Staphylococcus aureus which shows the ability to produce biofilm. Objectives: The aim of this work was to assess the influence of S. aureus biofilm on the course of atopic dermatitis. Methods: Disease severity was evaluated based on the SCORAD index in 56 adult patients with atopic dermatitis. Microtiter plate assay of the propensity to form biofilm was performed on S. aureus strains isolated from the anterior nares, lesional skin, and nonlesional skin. Microbiological results were correlated to the clinical parameters and total IgE concentration. Results: Biofilm-producing strains of S. aureus were identified in 76.3% (29/38) and 79.1% (34/43) of samples from the anterior nares and lesional skin, respectively (p > 0.05), and in 48.5% (16/33) of samples from nonlesional skin (p < 0.03). Patients colonized by biofilm-producing strains of S. aureus within the anterior nares showed statistically higher mean values of total and objective SCORAD and its components (extent, dryness), and of the largest extent of skin lesions during the flares in the last year when compared to patients colonized by non-biofilm-producing strains. Carriage of biofilm-producing S. aureus on lesional skin was associated with higher mean values of the extent of skin lesions during stable periods of the disease. Conclusions: The results of this study may suggest a relationship between the production of biofilm by S. aureus strains colonizing the anterior nares and the course of atopic dermatitis. Biofilm seems crucial for dispersal and persistent colonization of large areas of the skin by this pathogen. Destruction of S. aureus biofilm could positively affect the course of atopic dermatitis.

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“…Other niches have also been investigated in AD. Similarly to skin lesions, the nonlesional skin was revealed to harbor an increased load of S. aureus [81][82][83]. Furthermore, a report comparing the microbial composition of the nonlesional skin of AD patients and the skin of controls demonstrated the abundance of Streptococcus spp.…”

Section: The Skin Microbiome In Atopic Dermatitismentioning

confidence: 99%

The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update

Blicharz

Rudnicka

Czuwara

et al. 2021

IJMS

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Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin. According to recent research such phenomena are closely related to the microbial dysbiosis of the skin. There is growing evidence that cutaneous microbiota and bacterial biofilms negatively affect skin barrier function, contributing to the onset and exacerbation of AD. This review summarizes the latest data on the mechanisms leading to microbiome dysbiosis and biofilm formation in AD, and the influence of these phenomena on skin barrier function.

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Nasal Colonization by Staphylococci and Severity of Atopic Dermatitis

Cited by 12 publications

References 34 publications

Skin and nasal colonization of coagulase-negative staphylococci are associated with atopic dermatitis among South African toddlers

Skin and nasal colonization of coagulase-negative staphylococci are associated with atopic dermatitis among South African toddlers

The Propensity to Form Biofilm in vitro by <b><i>Staphylococcus aureus</i></b> Strains Isolated from the Anterior Nares of Patients with Atopic Dermatitis: Clinical Associations

The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update

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