Nasal and Tracheal Cytological Changes After Total Laryngectomy in Long-Term Survivors

Riva, Giuseppe; Boita, Monica; Corvino, Andrea; Sensini, Matteo; Peruzzetto, Daniela; Chiusa, Luigi; Pecorari, Giancarlo; Garzaro, Massimiliano

doi:10.1177/0003489416676500

Cited by 19 publications

(22 citation statements)

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“…However, laryngectomized patients have complete separation of upper and lower respiratory tracts. Riva et al [3,6] showed that direct airflow through the trachea may result in loss of these functions. Cytological and histological changes have also been studied among these impaired nasal functions of laryngectomized patients.…”

Section: Discussionmentioning

confidence: 99%

“…Cytological and histological changes have also been studied among these impaired nasal functions of laryngectomized patients. [3,4] It has been shown that mucosal transit time was affected and that epithelium of the nasal cavity transitioned to columnar epithelium. [7] Fisher et al [8] demonstrated mucosal atrophy and decreased number of goblet cells.…”

Section: Discussionmentioning

confidence: 99%

“…The nasal cavity is not used for breathing and this may cause certain physiological, cytological, and histological changes in the nasal cavity and mucosa. [3][4][5] However, among these changes, nasal polyposis is not an expected outcome in laryngectomized patients. To the best of our knowledge, this is the second report on this issue.…”

Section: Department Of Otolaryngology Selçuk University Faculty Of mentioning

confidence: 99%

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Nasal polyposis in laryngectomy patients

Erdur¹

2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Department Of Otolaryngology Selçuk University Faculty Of mentioning

confidence: 99%

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Nasal polyposis in laryngectomy patients

Erdur¹

2020

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“…In contrast to prior findings of other investigators, both Skoloudik et al and Riva et al found mucus cell hyperplasia and an increase in the number of bacteria in the nasal mucosa of laryngectomees, but with a notable absence of significant inflammation, suggesting colonization without true infection. 17,18 A 2008 cross-sectional analysis of nasal and sinus symptoms following laryngectomy showed an increase in the prevalence of rhinorrhea compared to before laryngectomy, in contrast to a decrease in common colds and acute and chronic rhinosinusitis. 3 Our study supported the findings of prior studies in that there was no difference in the self-reported incidence of sinusitis between laryngectomees and controls, but there was a higher incidence of rhinitis in laryngectomees.…”

Section: Discussionmentioning

confidence: 99%

Nasal Symptoms Following Laryngectomy: A Cross-sectional Analysis

Ayoub

Kearney

Sayyid

et al. 2020

Am J Rhinol�Allergy

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Background After total laryngectomy, the severe reduction in nasal airflow alters the function and physiology of the nasal cavity. These anatomic and physiologic changes may in turn impact sinonasal quality of life. Objective This study sought to characterize the degree of postoperative sinonasal symptoms experienced by laryngectomees. Methods Two groups of subjects were recruited in this cross-sectional analysis: patients who previously underwent laryngectomy with or without chemoradiation for laryngeal or hypopharyngeal cancer and a comparison group treated with radiation but not laryngectomy. Patients underwent assessment of sinonasal symptoms using the Reflective Total Nasal Symptom Score (rTNSS), 22-item Sinonasal Outcome Test (SNOT-22), and visual analog scales (VASs). Patients also underwent nasal endoscopy recorded and graded by blinded reviewers using the Modified Lund–Kennedy (MLK) scale. Results Thirty-six laryngectomees and 12 controls were enrolled. The total SNOT-22 was similar between the 2 groups (27.3 vs 20.3, P = .16), but the laryngectomy cohort had higher rhinologic ( P < .01), extranasal ( P = .01), and ear/face ( P = .01) subdomain scores. VAS scores were worse in the laryngectomy group for nasal congestion ( P < .01), rhinorrhea ( P < .01), postnasal drip ( P < .01), and smell ( P < .01) but not for nasal fullness ( P = .11). rTNSS (4.7 vs 2.8, P = .04) and MLK scores (2.8 vs 0.8, P < .01) were higher in the laryngectomy group. In addition, 44% and 83% of patients in the laryngectomy and nonlaryngectomy groups, respectively, subjectively reported well-controlled nasal symptoms. Conclusion Laryngectomees are likely to experience a higher degree of subjective and objective nasal disease than nonlaryngectomized patients. Postlaryngectomy nasal dysfunction may be an important aspect of quality of life impairment in the laryngectomee population.

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“…Some of the laryngectomees were previously evaluated for nasal and tracheal microbial colonization and cytology at our department. 11,12…”

Section: Methodsmentioning

confidence: 99%