Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride

Plessis, Lissinda H. Du; Kotzé, Abraham Frederick; Junginger, Hans E.

doi:10.3109/10717541003762888

Cited by 48 publications

(22 citation statements)

References 46 publications

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“…166 On the other hand, nanoparticles formed with chemically modified CS have proven successful with both TMC and thiolated CS derivatives. 132,134 For example, in a study it was found that thiolated CS nanoparticles produced an improvement in hypoglyceamia compared to the non-thiolated analog in healthy rats. 132 Similarly, the degree of quaternization of TMC was observed to positively affect the absorption of insulin associated to TMC based nanoparticles in rats.…”

Section: Nasal Drug/antigen Deliverymentioning

confidence: 97%

“…132 Similarly, the degree of quaternization of TMC was observed to positively affect the absorption of insulin associated to TMC based nanoparticles in rats. 134 Further to the solid matrix nanoparticle systems, salmon calcitonin (sCT) loaded CS nanocapsules produced a hypocalcaemic effect after nasal administration, where the CS coating resulted in an enhanced effect when compared to the control nanoemulsion. 150 Beyond the enhanced absorption of therapeutic peptides, the potential of CS-based nanocarriers as antigen delivery systems is well established.…”

Section: Nasal Drug/antigen Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Polysaccharide-Based Nanocarriers for Drug Delivery

Teijeiro¹,

McGlone²,

Csaba³

et al. 2014

Frontiers in Nanobiomedical Research

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Section: Nasal Drug/antigen Deliverymentioning

confidence: 97%

Section: Nasal Drug/antigen Deliverymentioning

confidence: 99%

Polysaccharide-Based Nanocarriers for Drug Delivery

Teijeiro¹,

McGlone²,

Csaba³

et al. 2014

Frontiers in Nanobiomedical Research

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“…These salts are soluble in water, the solubility depending on the degree of deacetylation and the pH of solution. To further enhance the solubility of this polymer and to improve its mucoadhesive and permeation enhancing properties, various derivatives such as chitosan glutamate, N-trimethyl chitosan chloride and thiolated chitosans have been developed (6)(7)(8). However, these processes require extensive chemical treatment and processing steps which in turn lead to increased expense and time.…”

Section: Introductionmentioning

confidence: 99%

Characterization of a novel lyophilized chitosan hydrogel complex for the controlled release of a highly water soluble drug, niacinamide.

Ma¹,

Prabhu²

2011

Int J Drug Del

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The purpose of this research was to prepare and characterize a novel lyophilized chitosan-based hydrogel complex (termed CS-M) for controlled drug delivery applications using a highly water soluble model drug, niacinamide. Characterization studies were undertaken to evaluate the physical-chemical properties, polymer swelling, in vitro controlled release kinetics, tissue bioadhesion, intestinal permeability and stability of the novel chitosan complex. Additionally, a comparative analysis was conducted with commercial polymers namely, Carbopol 974P-NF® and hydroxypropyl methylcellulose (HPMC K4M). FT-IR and 1 H NMR studies confirmed that despite alteration in physical structure and morphology of the chitosan complex the chemical properties remained unchanged, when compared to the parent chitosan compound. Polymer swelling studies showed consistency in the structural integrity and water uptake of CS-M compared to other polymers which showed inconsistent swelling and disintegration behavior over a 5 h period. In vitro controlled release profiles of CS-M showed a slower, more controlled release rate of niacinamide than other polymers indicating the influence of polymer swelling capacity on water uptake and subsequent drug release. CS-M demonstrated an overall increase in bioadhesion to intestinal tissue when compared to commercial polymers at same concentrations. Similarly, drug transport through everted sac intestinal tissue showed enhanced absorption properties of CS-M when compared to other polymers. Finally, a 3 month accelerated stability study showed all polymers including CS-M to be stable when formulated with niacinamide. Overall, the modified chitosan-based hydrogel polymer, CS-M, demonstrated enhanced characteristics indicating its potential to be used as a controlled release excipient in oral drug formulations.

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“…There are many reports about absorption enhancement effects of polycations by opening intercellular tight junctions, e.g. poly-L-arginine (Ohtake et al, 2003), chitosan (du Plessis et al, 2010;Rosenthal et al, 2012), poly-L-lysine and polyethylenimine (Ranaldi et al, 2002). This action is always followed by decrease in TEER and integrity of cell monolayers, and thus leads to risk of infection.…”

Section: Transport Of Plvs Across Caco-2 Cell Monolayersmentioning

confidence: 99%

Polymeric lipid vesicles with pH-responsive turning on–off membrane for programed delivery of insulin in GI tract

Fang

Xue

et al. 2016

Drug Delivery

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A kind of polymeric lipid vesicles (PLVs) with pH-responsive turning on-off membrane for programed delivery of insulin in gastrointestinal (GI) tract was developed, which was selfassembled from the grafted amphipathic polymer of N-tocopheryl-N 0 -succinyl-e-poly-L-lysine (TP/SC-g-PLL). By controlling the grafting ratio of hydrophobic alkane and ionizable carboxyl branches, the permeability of membrane was adjustable and thus allowing insulin release in a GI-pH dependent manner. The effects of grafting degree of substitution (DS) on the pHresponsive behavior of the formed vesicles were confirmed by critical aggregation concentration determination, morphology and size characterization. Their transepithelial permeability across the GI tract was proved by both confocal visualization in vitro model of Caco-2 cellular monolayer and in vivo hypoglycemic study in diabetic rats. Accordingly, the work described here indicated that the self-assembled PLVs could be a promising candidate for improving the GI delivery of hydrophilic biomacromolecule agents.

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Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride

Cited by 48 publications

References 46 publications

Polysaccharide-Based Nanocarriers for Drug Delivery

Polysaccharide-Based Nanocarriers for Drug Delivery

Characterization of a novel lyophilized chitosan hydrogel complex for the controlled release of a highly water soluble drug, niacinamide.

Polymeric lipid vesicles with pH-responsive turning on–off membrane for programed delivery of insulin in GI tract

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