Nasal administration of Carbamazepine using chitosan microspheres: In vitro/in vivo studies

Gavini, Elisabetta; Hegge, Anne Bee; Rassu, Giovanna; Sanna, Vanna; Testa, Cecilia; Pirisino, G; Karlsen, Jan; Giunchedi, Paolo

doi:10.1016/j.ijpharm.2005.09.013

Cited by 149 publications

(83 citation statements)

References 31 publications

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“…The distributions of the particle sizes were narrow, as described by He et al (1999b). Similar particle size results have been observed by several authors when using spray-drying technique for preparation of chitosan microspheres (Ganza-Gonzales et al, 1999;Giunchedi et al, 2002;Gavini et al, 2006).…”

Section: Size Distribution Of Microspheressupporting

confidence: 87%

“…The lower yields could be explained by aspiration of the small microspheres and attached polymer droplets in the spraying wall of the spray-dryer, as also reported by Giunchedi et al (2002) and Gavini et al (2006). The molecular weight of chitosan polymer used for formulations affected the production yields (p < 0.001).…”

Section: Preparation Of Microspheres and Percent Yield Valuesupporting

confidence: 58%

“…Even that given production yield results seemed to limited, there are studies in the literature that showed similar values (Giunchedi et al, 2002;Martinac et al, 2005;Gavini et al, 2006). The lower yields could be explained by aspiration of the small microspheres and attached polymer droplets in the spraying wall of the spray-dryer, as also reported by Giunchedi et al (2002) and Gavini et al (2006).…”

Section: Preparation Of Microspheres and Percent Yield Valuementioning

confidence: 64%

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Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

et al. 2010

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Section: Size Distribution Of Microspheressupporting

confidence: 87%

Section: Preparation Of Microspheres and Percent Yield Valuesupporting

confidence: 58%

Section: Preparation Of Microspheres and Percent Yield Valuementioning

confidence: 64%

See 1 more Smart Citation

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

et al. 2010

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“…An amount of free drug or microspheres corresponding to 2 mg of RK were used. At predetermined times (5,10,15,20,25,30,45, 60, 90, 120 and 180 min), 1 mL samples were withdrawn and the sample volume was replaced with fresh phosphate buffer. The samples withdrawn were centrifuged for 10 min at 13,000 rpm and the supernatant analysed.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

“…Chitosans have been used in the design of different types of drug carriers for various administration routes such as oral, ocular, buccal, nasal, transdermal, parenteral, vaginal. Chitosan dosage forms can be engineered into different shapes and geometries such as nanoparticles, microspheres, hydrogels, films, fibers, sponges and rods [25,26,[27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Improvement of Antiamoebic Activity of Rokitamycin Loaded in Chitosan Microspheres

Rassu¹,

Gavini²,

Mattana³

et al. 2008

TODDJ

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Rokitamycin is a new macrolide containing 16 carbon atoms, strongly inhibitory for Acanthamoeba castellanii, an opportunistic protozoa of humans which cause primarily amoebic keratitis and chronic, but fatal, amoebic granulomatous meningoencephalitis. Chitosan microspheres were prepared as carriers to obtain a controlled release of rokitamycin, able to improve the antiamoebic activity of this drug. The microparticles were in vitro characterised and the efficacy of rokitamycin alone and encapsulated into microspheres on the growth rate of Acanthamoeba castellani was evaluated. The results obtained suggest that spray-drying is a good technique for the preparation of microspheres loaded with rokitamycin. The loading of the drug into the polymeric network leads to an increase in the dissolution rate compared to drug raw material and improves and prolongs the in vitro antiamoebic activity of the drug. Thus, microspheres based on rokitamycin could be used in the therapy of systemic and topical infections caused by Acanthamoeba.

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Nasal Powder Drug Delivery

Filipović-Grčić

Hafner

2010

Pharmaceutical Sciences Encyclopedia

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Intranasal drug administration has been practiced since ancient times. Nasal dry powder formulations have been recognized as efficient nasal delivery systems offering numerous advantages over liquid formulations, such as avoidance of preservatives, improved formulation stability, and prolonged contact with the mucosa. This article focuses on the benefits associated with nasal dry powder formulations and microspheres as nasal drug delivery devices.

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Nasal administration of Carbamazepine using chitosan microspheres: In vitro/in vivo studies

Cited by 149 publications

References 31 publications

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Improvement of Antiamoebic Activity of Rokitamycin Loaded in Chitosan Microspheres

Nasal Powder Drug Delivery

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Nasal administration of Carbamazepine using chitosan microspheres: In vitro/in vivo studies

Cited by 149 publications

References 31 publications

Optimization of prednisolone acetate-loaded chitosan microspheres using a 23factorial design for preventing restenosis

Optimization of prednisolone acetate-loaded chitosan microspheres using a 23factorial design for preventing restenosis

Improvement of Antiamoebic Activity of Rokitamycin Loaded in Chitosan Microspheres

Nasal Powder Drug Delivery

Contact Info

Product

Resources

About

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis

Optimization of prednisolone acetate-loaded chitosan microspheres using a 2³factorial design for preventing restenosis