Nasal Adenoid Cystic Carcinoma with Intracranial Extension

Benazzou, Salma; Arkha, Yasser; Boulaadas, Malik; Derraz, S.; Essakali, L.; Kzadri, M.

doi:10.1097/01.scs.0000234984.99863.de

Cited by 4 publications

(8 citation statements)

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“…27 The indolence of SNACCs leads to late detection and treatment, increasing morbidity and mortality. 3,6,10…”

Section: Discussionmentioning

confidence: 99%

“…These tumors possess characteristics making them difficult to detect and treat, including (1) slow progression, (2) frequent local recurrence, (3) frequent metastases, and (4) low radiocurability 27 . The indolence of SNACCs leads to late detection and treatment, increasing morbidity and mortality 3,6 , 10…”

Section: Discussionmentioning

confidence: 99%

“…2,31,32 Nasal obstruction and difficulty breathing were the most frequently reported presenting symptoms, in line with prior reports. 32,33 Pain (head, 3 1 Cantor 68 1 Caruso 92 2 Cheng 93 1 Choi 94 2 Cleveland 37 3 Close 95 1 Close 96 2 Dal Maso 12 8 Delbouk 31 1 Dickoff 97 1 Fuchihata 98 7 Furue 99 1 Goldwyn 100 1 Gormley 101 2 Hair 102 2 Johnson 27 1 Kim 73 22 Kimmich 103 1 Kraus 104 1 Kwon 105 1 LoRusso 106 1 McCaffrey 107 1 Nakao 108 1 Parsons 109 1 Poetker 70 1 Rapidis 110 7 Ruo Redda 60 1 Sato 111 1 Schneiderman 112 1 Sessions 113 1 Spiers 54 1 Tai 114 1 Veillon 115 1 Wakisaka 57 1 Wolfowitz 116 3 Wolfowitz 117 1 Woo 118 1 Total 88 sinonasal, ocular, otologic, dental), enlarging mass/swelling, epistaxis, bone destruction, rhinorrhea/nasal discharge, facial anesthesia, blurred vision, exophthalmos, facial paralysis, and cognitive deficits were also reported. 34 Consistent with earlier reports, the maxillary...…”

Section: Clinical Informationmentioning

confidence: 99%

“…8,9 Adenoid cystic carcinomas are known for their prolonged history, insidious growth, and late diagnosis, with indolent recurrence and metastasis through the bloodstream. 3,6,10,11 This tumor has been considered incurable, due to its tendency to recur and metastasize by spreading submucosally and throughout major and minor nerves. [12][13][14][15] Sinonasal ACC (SNACC) has an especially poor prognosis and has remained relatively understudied.…”

mentioning

confidence: 99%

“…Adenoid cystic carcinoma (ACC), first described as a “cylindroma” by Billroth in the 1800s, is a rare tumor ( Figure 1). 1,2 Adenoid cystic carcinomas are malignant epithelial tumors of the exocrine glands originating from minor salivary glands of the upper respiratory tract 3,4 . Although ACCs have a predilection for the head and neck, they account for less than 2% of head and neck malignancies and 5% to 15% of malignant paranasal sinus tumors 4–7 .…”

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confidence: 99%

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Sinonasal Adenoid Cystic Carcinoma

Husain

Kanumuri

Svider

et al. 2012

Otolaryngol.--head neck surg.

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“…27 The indolence of SNACCs leads to late detection and treatment, increasing morbidity and mortality. 3,6,10…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Clinical Informationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Sinonasal Adenoid Cystic Carcinoma

Husain

Kanumuri

Svider

et al. 2012

Otolaryngol.--head neck surg.

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Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

Thompson

Penner

Ho³

et al. 2013

Head and Neck Pathol

119

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'Primary sinonasal tract and nasopharyngeal adenoid cystic carcinomas (STACC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. Eighty-six cases of STACC included 45 females and 41 males, aged 12-91 years (mean 54.4 years). Patients presented most frequently with obstructive symptoms (n = 54), followed by epistaxis (n = 23), auditory symptoms (n = 12), nerve symptoms (n = 11), nasal discharge (n = 11), and/or visual symptoms (n = 10), present for a mean of 18.2 months. The tumors involved the nasal cavity alone (n = 25), nasopharynx alone (n = 13), maxillary sinus alone (n = 4), or a combination of the nasal cavity and paranasal sinuses (n = 44), with a mean size of 3.7 cm. Patients presented equally between low and high stage disease: stage I and II (n = 42) or stage III and IV (n = 44) disease. Histologically, the tumors were invasive (bone: n = 66; neural: n = 47; lymphovascular: n = 33), composed of a variety of growth patterns, including cribriform (n = 33), tubular (n = 16), and solid (n = 9), although frequently a combination of these patterns was seen within a single tumor. Pleomorphism was mild with an intermediate N:C ratio in cells containing hyperchromatic nuclei. Reduplicated basement membrane and glycosaminoglycan material was commonly seen. Necrosis (n = 16) and atypical mitotic figures (n = 11) were infrequently present. Pleomorphic adenoma was present in 9 cases; de-differentiation was seen in two patients. Immunohistochemical studies showed positive reactions for pan-cytokeratin, CK7, CK5/6, CAM5.2, and EMA, with myoepithelial reactivity with SMA, p63, calponin, S100 protein and SMMHC. CD117, CEA, GFAP and p16 were variably present. CK20 and HR HPV were negative. STACC needs to be considered in the differential diagnosis of most sinonasal malignancies, particularly poorly differentiated carcinoma, olfactory neuroblastoma and pleomorphic adenoma. Surgery (n = 82), often accompanied by radiation therapy (n = 36), was generally employed. A majority of patients developed a recurrence (n = 52) 2-144 months after initial presentation. Overall mean follow-up was 19.4 years (range 0.4-37.5 years): 46 patients died with disease (mean 6.4 years); 5 were alive with disease (mean 5.4 years), and 35 patients were either alive or had died of unrelated causes (mean 16.3 years). ACC of the SNT is uncommon. Recurrences are common. The following parameters, when present, suggest an increased incidence of either recurrence or dying with disease: mixed site of involvement, high stage disease (stage IV), skull base involvement, tumor 123Head and Neck ) 8:88-109 DOI 10.1007 recurrence, a solid histology, perineural invasion, bone invasion, and lymphovascular invasion.

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Carcinoma adenoide cístico intracraniano

Welling¹,

Lynch²,

Andrade³

et al. 2011

Arq Bras Neurocir

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ResumoOs carcinomas adenoides císticos são tumores de crescimento lento, localmente agressivos e com tendência à recorrência. Têm particular interesse por infiltrar estruturas neurais e disseminar-se pelo perineuro. Envolvimento intracraniano é raro. Descreve-se um caso de carcinoma adenoide cístico originado na glândula lacrimal esquerda e invasão do seio cavernoso. Ressonância magnética demonstrou lesão tumoral, extra-axial, bem delimitada, semelhante a um meningioma da asa do esfenoide com invasão do seio cavernoso. O paciente apresentou boa resposta ao tratamento com cirurgia e radioterapia complementar.

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Nasal Adenoid Cystic Carcinoma with Intracranial Extension

Cited by 4 publications

References 12 publications

Sinonasal Adenoid Cystic Carcinoma

Sinonasal Adenoid Cystic Carcinoma

Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

Carcinoma adenoide cístico intracraniano

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