Sinonasal Adenoid Cystic Carcinoma

Husain, Qasim; Kanumuri, Vivek V.; Svider, Peter F.; Radvansky, Brian M.; Boghani, Zain; Liu, James K.; Eloy, Jean Anderson

doi:10.1177/0194599812464020

Cited by 69 publications

(25 citation statements)

References 116 publications

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“…The prognostic effects of solid histopathology are controversial. Some believes it means a lower rate of survival when compared with the tubular or cribriform type, whereas others have shown that there is no relationship [46, 47]. The combined analysis showed that the recurrence rate of patients with positive expression of p53 was 43.1%, and that of patients with negative expression of p53 was 20%.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis

Huang

Zheng

et al. 2017

Oncotarget

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Adenoid cystic carcinoma of salivary glands is a rare adenocarcinoma and has been placed in “high-risk” category as poor long-term prognosis. The purpose of this study was to investigate p53 protein expression in adenoid cystic carcinoma of salivary glands and its correlation with clinicopathological parameters and prognosis. Literatures were searched from PubMed, Embase, Cochrane Library and Web of Science, which investigated the relationships between p53 expression and pathological type, clinical stage, local recurrence, metastasis, nerve infiltration and overall survival. A total of 1,608 patients from 36 studies were included in the analysis. The results showed that p53-postive expression rate was 49% in adenoid cystic carcinoma of salivary glands (OR=10.34, 95%CI: 4.93-21.71, P < 0.0001). The p53-postive expression was closely related to tumor types (OR=0.30, 95%CI: 0.14-0.65, P < 0.0001). The tumor with solid histological subtype had a strong positive correlation with p53 expression. The combined analysis revealed that the p53-positive expression rate among patients in T1and T2 stage was 41.4%, compared to 53.2% among those in T3 and T4 stage. However, there was no significant correlation between tumor stage and p53 expression (OR=0.47, 95% CI: 0.17-1.29, P = 0.14). Besides, compared to patients with p53-negative expression, those with p53-positive expression had a greater chance of developing metastasis, local recurrence and nerve infiltration as well as poorer 5-year overall survival (P < 0.01). In conclusion, the p53 expression is related to the survival of adenoid cystic carcinoma of salivary glands. It can be considered as the auxiliary detection index in treatment and prognosis of adenoid cystic carcinoma of salivary glands.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis

Huang

Zheng

et al. 2017

Oncotarget

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“…Upon presentation, SNACC frequently involves local vital structures such as orbit, cranial nerves, brain, dura and carotid arteries, limiting the option for aggressive surgery . Because of its tendency to present in an advanced stage, surgery with adjuvant radiotherapy has been the mainstay of treatment for SNACC . However, studies assessing the most effective treatment modalities for SNACC have presented contrasting results.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Trope

Triantafillou

Kohanski

et al. 2019

Int Forum Allergy Rhinol

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Background: Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). Methods:This was a retrospective, population-based cohort study performed at a tertiary academic medical center. All participants were diagnosed with SNACC between 2004 and 2012 within the NCDB. The main outcome was overall survival (OS). Results:A total of 793 patients were identified. The cohort was composed of 46.9% males. Mean age at diagnosis was 59.6 years. The maxillary sinus was the most common primary site (49.7%). Nodal disease was seen in 3.6% of the patients, whereas 3.7% had distant metastases. Stage IV disease was seen in 49.1% of cases. In total, 77.4% of patients underwent surgery, 68.2% received radiation therapy, and 16.4% had chemotherapy. Median OS was 78.5 months; OS at 1, 2, and 5 years was 91%, 83%, and 61%, respectively. On multivariate analysis, advanced age (p = 0.001), frontal sinus primary site (p < 0.001), positive margins (p < 0.001), Charlson comorbidity index >0 (p = 0.01), residing in an urban se ing (p = 0.04), poorly differentiated or undifferentiated tumor grade (p = 0.003), and advanced tumor stage (p = 0.01) were associated with worse OS, whereas surgery (p < 0.001), but not radiation therapy (p = 0.52) or chemotherapy (p = 0.57), predicted improved OS. Conclusion:Predictors of survival in SNACC include age, comorbidity status, grade, and stage. Surgery is associated with improved survival and remains the mainstay of therapy, whereas the roles of radiation therapy and chemotherapy require future investigation. C 2019 ARS-AAOA, LLC.

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“…A systematic review consisting of both individual and aggregate SNACC patient data reported a 5-year survival rate of 62.5%. 22 A retrospective cohort study using the United States National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) registry identified a total of 412 cases between 1973 and 2009. The 5-year OS rate was 68.8% with African Americans having inferior survival compared to other races, which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus

et al. 2017

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Background The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (SNACC) and to clarify its association with human papilloma virus (HPV). Methods The medical records of 23 patients with SNACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. p16 testing was performed using immunohistochemistry and HPV infection was determined using quantitative polymerase chain reaction with primers targeting the E6/E7 region. Results Two of the 17 samples showed strong and diffuse p16 staining, while the remaining 15 cases showed p16 positivity isolated to the luminal cells. Only one of the p16 positive cases was positive for HPV. The 5-year local failure, disease-free survival, and overall survival were 51%, 52%, and 62%, respectively. Conclusions Local failures are common with advanced SNACC, and the association of HPV with true SNACC is low.

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Sinonasal Adenoid Cystic Carcinoma

Abstract: This study contains the largest pool of SNACC patients to date. The data suggest that SNACC has a poor overall prognosis. It also suggests that surgery with postoperative radiotherapy is the most commonly used and may possibly be the most effective therapy.

Cited by 69 publications

References 116 publications

Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis

Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus

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