Simple logistics strategies such as "carry-along" and Earth-based "resupply" were sufficient for past human space programs. Next-generation space logistics paradigms are expected to be more complex, involving multiple exploration destinations and insitu resource utilization (ISRU). Optional ISRU brings additional complexity to the interplanetary supply chain network design problem. This paper presents an interdependent network flow modeling method for determining optimal logistics strategies for space exploration and its application to the human exploration of Mars. It is found that a strategy utilizing lunar resources in the cislunar network may improve overall launch mass to low Earth orbit for recurring missions to Mars compared to NASA's Mars Design Reference Architecture 5.0, even when including the mass of the ISRU infrastructures that need to be pre-deployed. Other findings suggest that chemical propulsion using LOX/LH 2 , lunar ISRU water production, and the use of aerocapture significantly contribute to reducing launch mass from Earth. A sensitivity analysis