Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system

Shin, D.M.; Peelman, Kayla; Rosario, Joseph Del; Haider, Bilal

doi:10.1101/2022.05.19.491028

Cited by 3 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2a,c). Frozen noise drove highly repeatable time-locked sequences of action potentials in the recorded neurons, consistent with prior work 16,[40][41][42][43] (Fig. 2b, left).…”

Section: Balanced Bidirectional Optogeneticssupporting

confidence: 87%

Balanced bidirectional optogenetics reveals the causal impact of cortical temporal dynamics in sensory perception

Quintana,

Bounds,

Veit

et al. 2024

Preprint

View full text Add to dashboard Cite

Whether the fast temporal dynamics of neural activity in brain circuits causally drive perception and cognition remains one of most longstanding unresolved questions in neuroscience1–6. While some theories posit a ‘timing code’ in which dynamics on the millisecond timescale is central to brain function, others instead argue that mean firing rates over more extended periods (a ‘rate code’) carry most of the relevant information. Existing tools, such as optogenetics, can be used to alter temporal structure of neural dynamics7, but they invariably change mean firing rates, leaving the interpretation of such experiments ambiguous. Here we developed and validated a new approach based on balanced, bidirectional optogenetics that can alter temporal structure of neural dynamics while mitigating effects on mean activity. Using this new approach, we found that selectively altering cortical temporal dynamics substantially reduced performance in a sensory perceptual task. These results demonstrate that endogenous temporal dynamics in the cortex are causally required for perception and behavior. More generally, this new bidirectional optogenetic approach should be broadly useful for disentangling the causal impact of different timescales of neural dynamics on behavior.

show abstract

“…2a,c). Frozen noise drove highly repeatable time-locked sequences of action potentials in the recorded neurons, consistent with prior work 16,[40][41][42][43] (Fig. 2b, left).…”

Section: Balanced Bidirectional Optogeneticssupporting

confidence: 87%

Balanced bidirectional optogenetics reveals the causal impact of cortical temporal dynamics in sensory perception

Quintana,

Bounds,

Veit

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…For consistency of our studies, in this study, we chose the HG frequency range as 50 to 150 Hz and divided it into two components: lower component of HG activity (LHG; 50 to 70 Hz) which is similar to the narrowband gamma oscillation in other studies, and higher component of HG activity (HHG; 70 to 150 Hz). The boundary of two components (70 Hz) was determined based on the frequency range of conventional gamma oscillation (30 to 70 Hz), a recent study (narrowband gamma oscillation: 50 to 70 Hz) (Shin et al, 2023), and visual inspection of our data. Note that slight changes in boundary frequency (65 to 75 Hz) did not significantly affect the main results.…”

Section: Resultsmentioning

confidence: 99%

“…A vision study suggested that narrowband gamma oscillation is strongest in layer IV and reflects the signal flow from the thalamus to the cortex (Saleem et al, 2017). Furthermore, a recent study suggested that narrowband gamma oscillations (50 to 70 Hz) propagate and synchronize throughout the thalamocortical visual system in mice (Shin et al, 2023). Consistent with previous vision studies, in the current somatosensory study, we observed that LHG power was strongest in layer IV.…”

Section: Discussionmentioning

confidence: 99%

“…In vision studies, it has been suggested that broadband (∼80 to 200 Hz) and narrowband gamma (close to 60 Hz) activities in the primary visual cortex (V1) have different origins and functions in mice and monkeys (Ray and Maunsell, 2011; Saleem et al, 2017). In particular, a recent study indicated that narrowband gamma activities (50 to 70 Hz) are closely associated with neuronal firing in the lateral geniculate nucleus (LGN) of the thalamus and propagate throughout the thalamocortical visual system, including V1 and higher visual areas (Shin et al, 2023). A human vision study using ECoG suggested that narrowband gamma (∼20 to 60) and broadband gamma (∼70 to 150+ Hz) activities showed distinct spectral, temporal, and functional properties (Bartoli et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct Functional Roles of Narrow and Broadband High-Gamma Activities in Human Primary Somatosensory Cortex

Ryun,

Chung

2024

Preprint

View full text Add to dashboard Cite

In previous studies, higher (broadband) and lower (narrowband) components of high-gamma (HG) activity (approximately from 50 to 150 Hz) have different functions and origins in the primary visual cortex (V1). However, in the primary somatosensory cortex (S1), it is unknown whether those are similarly segregated. Furthermore, the origin and functional role of S1 HG activity still remain unclear. Here, we investigate their roles by measuring neural activity during vibrotactile and texture stimuli in humans. Also, to estimate their origins, S1 layer-specific HG activity was measured in rats during somatosensory stimulation. In the human experiment, with texture stimulation, the lower HG activity (LHG, 50-70 Hz) in S1 represents the intensity of the sustained mechanical stimulus. In the vibrotactile experiment, the higher HG (HHG, 70 -150 Hz) activity in S1 depended on the ratio of low and high mechanical frequencies with its pattern being a mixture of neural activity for low and high mechanical frequencies. Furthermore, 8 texture types could be classified using power values of HHG activity, while the classification using LHG activity showed poor performance. In the rat experiment, we found that both HHG and LHG activities are highest in the somatosensory input layer (layer IV), similar to previous visual cortex studies. Interestingly, analysis of spike-triggered LFP (stLFP) revealed significant HG oscillations during pressure stimulation with the stLFP HG power most significant in layer IV, suggesting that both LHG and HHG activities are closely related to the neuronal firing in layer IV. In summary, LHG activity represents the intensity of tactile sensation, while HHG activity represents the detail of the surface geometry of objects interacting with skin. Additionally, low and high mechanical frequencies are processed in parallel in S1. Finally, both HHG and LHG originated in layer IV of S1.

show abstract

“…Recently, it was found that narrow gamma oscillations propagate beyond V1, potentially serving as a key mechanism for coordinated spiking across the mouse visual system. (Shin et al., 2023), indeed, it has been reported that several neurons in LGN, V1, and higher visual areas showed tightly coordinated narrow gamma band spiking and a high likelihood for pairwise functional interactions.…”

Section: Introductionmentioning

confidence: 91%

Rodents’ visual gamma as a biomarker of pathological neural conditions

Meneghetti,

Vannini,

Mazzoni

2024

The Journal of Physiology

View full text Add to dashboard Cite

Neural gamma oscillations (indicatively 30–100 Hz) are ubiquitous: they are associated with a broad range of functions in multiple cortical areas and across many animal species. Experimental and computational works established gamma rhythms as a global emergent property of neuronal networks generated by the balanced and coordinated interaction of excitation and inhibition. Coherently, gamma activity is strongly influenced by the alterations of synaptic dynamics which are often associated with pathological neural dysfunctions. We argue therefore that these oscillations are an optimal biomarker for probing the mechanism of cortical dysfunctions. Gamma oscillations are also highly sensitive to external stimuli in sensory cortices, especially the primary visual cortex (V1), where the stimulus dependence of gamma oscillations has been thoroughly investigated. Gamma manipulation by visual stimuli tuning is particularly easy in rodents, which have become a standard animal model for investigating the effects of network alterations on gamma oscillations. Overall, gamma in the rodents’ visual cortex offers an accessible probe on dysfunctional information processing in pathological conditions. Beyond vision‐related dysfunctions, alterations of gamma oscillations in rodents were indeed also reported in neural deficits such as migraine, epilepsy and neurodegenerative or neuropsychiatric conditions such as Alzheimer's, schizophrenia and autism spectrum disorders. Altogether, the connections between visual cortical gamma activity and physio‐pathological conditions in rodent models underscore the potential of gamma oscillations as markers of neuronal (dys)functioning. image

show abstract

Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system

Cited by 3 publications

References 53 publications

Balanced bidirectional optogenetics reveals the causal impact of cortical temporal dynamics in sensory perception

Balanced bidirectional optogenetics reveals the causal impact of cortical temporal dynamics in sensory perception

Distinct Functional Roles of Narrow and Broadband High-Gamma Activities in Human Primary Somatosensory Cortex

Rodents’ visual gamma as a biomarker of pathological neural conditions

Contact Info

Product

Resources

About