Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF-κB/COX-2-caspase-1 pathway in HeLa cervical cancer cells

Zeng, Liyun; Zhen, Yulan; Chen, Yiming; Zou, Lin; Zhang, Ying; Hu, Fang; Feng, Jianqiang; Shen, Jianhua; Wei, Bing

doi:10.3892/ijo.2014.2617

Cited by 70 publications

(41 citation statements)

References 49 publications

(62 reference statements)

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“…On the other hand, caspase‐1 that cleaves pro‐IL‐1β to mature IL‐1β, is an activator of NF‐κB. Interestingly, the NF‐κB‐COX‐2/caspase‐1 pathway has been demonstrated to be responsible for cell growth, anti‐apoptosis and inflammation in CC cells . Toll‐like receptor 4 (TLR4) is a pattern recognition (or Toll‐like) receptor, which is also associated with tumor growth and inflammation in CC.…”

Section: Inflammation and CCmentioning

confidence: 99%

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Nahand

Moghoofei

Salmaninejad

et al. 2019

Intl Journal of Cancer

179

108

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Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most important risk factor for the development of CC is cervical infection with human papilloma virus (HPV). Inflammation is a protective strategy that is triggered by the host against pathogens such as viral infections that acts rapidly to activate the innate immune response. Inflammation is beneficial if it is brief and well controlled; however, if the inflammation is excessive or it becomes of chronic duration, it can produce detrimental effects. HPV proteins are involved, both directly and indirectly, in the development of chronic inflammation, which is a causal factor in the development of CC. However, other factors may also have a potential role in stimulating chronic inflammation. MicroRNAs (miRNAs) (a class of noncoding RNAs) are strong regulators of gene expression. They have emerged as key players in several biological processes, including inflammatory pathways. Abnormal expression of miRNAs may be linked to the induction of inflammation that occurs in CC. Exosomes are a subset of extracellular vesicles shed by almost all types of cells, which can function as cargo transfer vehicles. Exosomes contain proteins and genetic material (including miRNAs) derived from their parent cells and can potentially affect recipient cells. Exosomes have recently been recognized to be involved in inflammatory processes and can also affect the immune response. In this review, we discuss the role of HPV proteins, miRNAs and exosomes in the inflammation associated with CC.

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Section: Inflammation and CCmentioning

confidence: 99%

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Nahand

Moghoofei

Salmaninejad

et al. 2019

Intl Journal of Cancer

179

108

View full text Add to dashboard Cite

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“…Naringin (750 μM) showed an anti-proliferative effect on SiHa human cervical cancer cells through cell cycle arrest in the G2/M phase and apoptosis induction via disruption of mitochondrial transmembrane potential, and the activation of both the intrinsic and extrinsic pathways [130]. By contrast, naringin (1 mM) induced growth inhibition and apoptosis by suppressing the NF-κB/COX-2-caspase-1 pathway on HeLa cells [131]. Recently, the role of glycoconjugates in cancer cells has been a focus because of their regulatory effects on malignant phenotypes.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

et al. 2016

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Fruits and vegetables have long been recognized as potentially important in the prevention of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown by increasing number of experimental studies about the relationship between diet and cancer development. This review attempts to provide an insight into the anti-cancer effects of Citrus fruits, with a focus on their bioactive compounds, elucidating the main cellular and molecular mechanisms through which they may protect against cancer. Scientific literature was selected for this review with the aim of collecting the relevant experimental evidence for the anti-cancer effects of Citrus fruits and their flavonoids. The findings discussed in this review strongly support their potential as anti-cancer agents, and may represent a scientific basis to develop nutraceuticals, food supplements, or complementary and alternative drugs in a context of a multi-target pharmacological strategy in the oncology.

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“…Previous studies indicate that naringin suppressed cell growth of HeLa cervical cancer cells (18), human triple-negative breast cancer cells (19) and P388 cells (20). Therefore, it is hypothesized that naringin may be used as an effective anticancer agent for therapy in lung cancer.…”

Section: Discussionmentioning

confidence: 99%

miR‑126/VCAM‑1 regulation by naringin suppresses cell growth of human non‑small cell lung cancer

Chen

Peng

et al. 2018

Oncol Lett

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Abstract. Certain studies have indicated that naringin possesses various pharmacological activities including anti-aging, anti-oxidation, anticancer, cardiovascular and cerebrovascular disease prevention, in addition to anti-hepatic effects. The present study explores the anticancer effect of naringin on human small cell lung cancer H69AR cells. Cell growth and apoptosis rates of H69AR cells were measured by MTT or flow cytometry, which demonstrated naringin suppressed cell growth and induced apoptosis of H69AR cells. MicroRNA (miR)-126 expression and levels of phosphorylated protein kinase B (AKT), mechanistic target of rapamycin (mTOR), nuclear factor (NF)-κB and vascular cell adhesion molecule 1 (VCAM-1) proteins were detected by quantitative polymerase chain reaction and western blotting. It was identified that naringin increased miR-126 expression and suppressed the phosphorylation of AKT, mTOR, NF-κB and VCAM-1 proteins in H69AR cells. Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels. However, close of miR-126 expression did not affect the levels of NF-κB protein in H69AR cells. In summary, naringin exhibits its anti-cancer effect by suppressing cell growth of small cell lung cancer cells through miR-126/VCAM-1 signaling pathway.

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Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF-κB/COX-2-caspase-1 pathway in HeLa cervical cancer cells

Cited by 70 publications

References 49 publications

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: A review

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

miR‑126/VCAM‑1 regulation by naringin suppresses cell growth of human non‑small cell lung cancer

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