Naringin abrogates HIV-1 protease inhibitors-induced atherogenic dyslipidemia and oxidative stress in vivo

Nzuza, Sanelisiwe; Owira, Peter M. O.

doi:10.1016/j.jff.2018.11.007

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…This increase in redox imbalance was ameliorated by Nar treatment in a dose-dependent manner, possibly by its direct ability to scavenge free radicals [37], or through the transcriptional up-regulation of antioxidant genes [38]. These results are consistent with reports of other investigators [31,39,40]. Several studies have reported that the antioxidant and anti-inflammatory effects of Nar are retained up to 400 mg/kg exposure [41][42][43].…”

Section: Discussionsupporting

confidence: 86%

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells

et al. 2020

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Methotrexate (MTX) is an efficient chemotherapeutic and immunosuppressant drug, but the hepatotoxicity of MTX limits its clinical use. Naringin (Nar) is a flavonoid derived from Citrus paradise, and has been shown to possess several pharmacological activities, including free-radical scavenging and antioxidant properties. In the present study, we first tested the possible protective effects of multiple doses of Nar against MTX-induced acute hepatotoxicity in rats, and then we investigated the growth inhibition and apoptotic effects of MTX and/or Nar against the HepG2 hepatocarcinoma cell line. Our in vivo results showed that Nar significantly reduced MTX-induced increases in serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin levels. Nar also reduced MTX-induced oxidative stress by significantly reducing liver malondialdehyde (MDA) and nitric oxide (NO) content and increasing superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH). In addition, Nar significantly counteracted MTX-induced increases in hepatic interleukin-6 and tumor necrosis factor-α (TNF-α). Further, Nar greatly protected hepatocyte ultrastructure against MTX-induced injury. In contrast, in vitro MTX and/or Nar treatment of HepG2 cells for 48 h exhibited a cytotoxic effect and induced apoptosis in a dose-dependent manner mediated by a significant increase in the Bax/Bcl-2 protein expression ratio. Noticeably, Nar potentiated the MTX effect on the Bax/Bcl-2 ratio. In conclusion, Nar decreased MTX-induced functional and ultrastructural liver damage in a tumor-free animal model. Also, our data introduce MTX and Nar as promising antiproliferative agents with a distinctive mode of action, inducing apoptosis in HepG2 tumor cells through activation of Bax and down-regulation of Bcl-2 protein expression.

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Section: Discussionsupporting

confidence: 86%

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells

et al. 2020

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Section: Targeting Er Stress By Bbr Under Pathological Conditionsmentioning

confidence: 99%

“…Human immunodeficiency virus (HIV) protease inhibitors are used in therapy for HIV infection, which causes sustained suppression of viral replication (Nzuza & Owira, 2019). Dyslipidemia and its complications, such as atherosclerosis and endothelial dysfunction, are the side effects of HIV protease inhibitors treatment (Nzuza & Owira, 2019). Multiple mechanisms are involved in complications associated with the HIV protease inhibitors, including apoptosis inflammation and ER stress (Gruevska et al, 2021; Nzuza & Owira, 2019).…”

Section: Targeting Er Stress By Bbr Under Pathological Conditionsmentioning

confidence: 99%

“…Dyslipidemia and its complications, such as atherosclerosis and endothelial dysfunction, are the side effects of HIV protease inhibitors treatment (Nzuza & Owira, 2019). Multiple mechanisms are involved in complications associated with the HIV protease inhibitors, including apoptosis inflammation and ER stress (Gruevska et al, 2021; Nzuza & Owira, 2019). The inhibitory effect of BBR on HIV protease inhibitor‐induced inflammation in murine macrophages has been shown (Zha et al, 2010).…”

Section: Targeting Er Stress By Bbr Under Pathological Conditionsmentioning

confidence: 99%

“…Multiple mechanisms are involved in complications associated with the HIV protease inhibitors, including apoptosis inflammation and ER stress (Gruevska et al, 2021;Nzuza & Owira, 2019). The inhibitory effect of BBR on HIV protease inhibitor-induced inflammation in murine macrophages has been shown (Zha et al, 2010).…”

Section: Infectionmentioning

confidence: 99%

See 2 more Smart Citations

The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress

Yarmohammadi

Hayes

Karimi

2022

Phytotherapy Research

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Various factors interfere with the endoplasmic reticulum (ER) function, which is involved in protein folding and calcium homeostasis. ER dysfunction referred to as ER stress triggers cell death by apoptosis and inflammation. Berberine (BBR) is an alkaloid extracted from the family Berberidacea. It has shown multiple pharmacological activities, including anti-inflammatory, antioxidative, anti-apoptotic, antiproliferative, and antihypertensive. It has been reported that BBR can decrease apoptosis and inflammation following different pathological conditions, which might be mediated by targeting ER stress pathways.In this manuscript, we reviewed the protective potential of BBR against several diseases, such as metabolic disorders, cancer, intestinal diseases, cardiovascular, liver, kidney, and central nervous system diseases, in both in vivo and in vitro studies.

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DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?

Lutu

Nzuza

Mato

et al. 2019

European Journal of Pharmacology

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Naringin abrogates HIV-1 protease inhibitors-induced atherogenic dyslipidemia and oxidative stress in vivo

Cited by 7 publications

References 45 publications

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells

The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress

DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?

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