DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?

Lutu, Mathabo Ruth; Nzuza, Sanelisiwe; Mato, Pascale Edith Mofo; Govender, Khmera; Gumede, Londiwe Mphumelelo; Kumalo, Sinenhlanhla Innocentia; Mlambo, Nontokozo Nomfundo; Hurchund, Ranjendraparsad; Owira, Peter M. O.

doi:10.1016/j.ejphar.2019.03.017

Cited by 4 publications

(3 citation statements)

References 122 publications

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“…78,108 NAR had been recommended as a therapeutic adjunct to Nucleoside-Reverse-Transcriptase-Inhibitors for antiretroviral therapy. 139 In silico docking studies have demonstrated blocking of the neuraminidase site by NAR and other flavonoids in Influenza Type A viruses. 140 Thus, NAR exhibits a broad-spectrum antiviral activity which involves inhibiting a variety of viruses.…”

Section: Antiviral Significance Of Naringeninmentioning

confidence: 99%

Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19

Agrawal¹,

Agrawal²,

Blunden

2021

Natural Product Communications

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Naringenin, widely distributed in fruits and vegetables, is endowed with antiviral and other health beneficial activities, such as immune-stimulating and anti-inflammatory actions that could play a role in contributing, to some extent, to either preventing or alleviating coronavirus infection. Several computational studies have identified naringenin as one of the prominent flavonoids that can possibly inhibit internalization of the virus, virus-host interactions that trigger the cytokine storm, and replication of the virus. This review highlights the antiviral potential of naringenin in COVID-19 associated risk factors and its predicted therapeutic targets against SARS-CoV-2 infection.

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Section: Antiviral Significance Of Naringeninmentioning

confidence: 99%

Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19

Agrawal¹,

Agrawal²,

Blunden

2021

Natural Product Communications

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“…MtDNA also encodes 24 transfer RNAs (t-RNAs) required for protein synthesis in mitochondria. An important feature of mitochondria is that almost all mtDNA comes from unfertilized oocytes [13][14][15] . Most researchers believe that, in fact, from the time of fertilization, the paternal mtDNA without sperm can survive into the fertilized egg, so the embryo only develops with the maternal mtDNA.…”

Section: Structure Function and Genetics Of Mitochondriamentioning

confidence: 99%

Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells

Liu

Qin

Cong

2022

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Lung cancer is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers, and lung adenocarcinoma is the most common NSCLC. Most patients with lung cancer eventually lead to local and metastatic recurrence, including many patients who have completely removed the primary tumor during surgery and have no noticeable metastasis. There are two different deoxynucleotide triphosphate (dNTP) libraries in eukaryotic cells. The de novo synthesis of dNTPs in the cytoplasm is coordinated with the cell cycle and reaches a peak in the S phase, thereby providing deoxynucleotides for the replication of genomic DNA. In contrast, the mitochondrial pool of dNTPs is maintained through the mitochondrial deoxynucleoside rescue pathway throughout the cell cycle and is essential for mtDNA replication. Mitochondria are vital cell powers in assimilation and catabolism. Oxidative phosphorylation (OXPHOS) of mitochondria is essential for the self-renewal of cancer stem-like cells in lung cancer, glioblastoma and leukemia. Thymidine kinase 2 (TK2) and deoxyguanosine kinase (DGUOK) are two mitochondrial deoxynucleoside kinases, which are responsible for the transport of pyrimidine and purine deoxynucleoside in mitochondria. Apoptosis and autophagy are important processes that regulate cell proliferation and death in normal cells and cancer cells. Inducing cancer cell apoptosis and autophagy is an effective means to treat malignant tumors. This review discusses the research progress of the relationship between mitochondrial deoxyguanosine kinase and lung adenocarcinoma cell apoptosis and autophagy.

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“…Naringenin because of its potent free radicle scavenging activity, had been recommended as a therapeutic adjunct to Nucleoside-reversetranscriptase-inhibitors (NRTIs) for antiretroviral therapy (cARVs). The combination had been proposed to mitigate the mitochondrial toxicity of these drugs [22]. In silico docking studies with different flavonoids had demonstrated the blocking of neuraminidase site by naringenin and other flavonoids in Influenza Type A viruses [23].…”

Section: Anti-viral Properties Of Naringeninmentioning

confidence: 99%

Therapeutic Applications of Naringenin, a Flavanone Enriched in Citrus Fruits, for Disorders beyond Diabetes

Jaswinder¹,

Vyas²,

Singh³

et al. 2020

Phyton

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In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin in managing disorders other than diabetes and its role in regulating gene expression by altering chromatin structure as histone deacetylase inhibitor. The understanding of these phenomena will increase the overall knowledge of the various health-promoting effects of citrus fruits.

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DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin?

Cited by 4 publications

References 122 publications

Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19

Naringenin as a Possible Candidate Against SARS-CoV-2 Infection and in the Pathogenesis of COVID-19

Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells

Therapeutic Applications of Naringenin, a Flavanone Enriched in Citrus Fruits, for Disorders beyond Diabetes

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