Naringenin protects against scopolamine-induced dementia in rats

Zaki, Hala F.; AbdelFattah, May; Attia, Amina S.

doi:10.1016/j.bfopcu.2013.11.001

Cited by 66 publications

(39 citation statements)

References 50 publications

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“…Along with this, during aging cholinergic and catecholaminergic systems are also severely affected [44]. Disturbance in cholinergic neurotransmission strongly correlates with the extent of dementia and severity of neuropathological changes associated with AD [63]. Impaired cholinergic functions in brain are considered to be involved in cognitive dysfunction associated with aging [39].…”

Section: Discussionmentioning

confidence: 99%

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

et al. 2020

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Currently prescribed medications for the treatment of Alzheimer's disease (AD) that are based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide protection against neurodegeneration. There appear to be an intense need for the development of therapeutic strategies that not only improve brain functions but also prevent neurodegeneration. The oxidative stress is one of the main causative factors of AD. Various antioxidants are being investigated to prevent neurodegeneration in AD. The objective of this study was to investigate the neuroprotective effects of naringenin (NAR) against AlCl 3 +D-gal induced AD-like symptoms in an animal model. Rats were orally pre-treated with NAR (50 mg/kg) for two weeks and then exposed to AlCl 3 +D-gal (150 mg/kg + 300 mg/kg) intraperitoneally for one week to develop AD-like symptoms. The standard drug, donepezil (DPZ) was used as a stimulator of cholinergic activity. Our results showed that NAR pre-treatment significantly protected AD-like behavioral disturbances in rats. In DPZ group, rats showed improved cognitive and cholinergic functions but the neuropsychiatric functions were not completely improved and showed marked histopathological alterations. However, NAR not only prevented AlCl 3 +D-gal induced AD-like symptoms but also significantly prevented neuropsychiatric dysfunctions in rats. Results of present study suggest that NAR may play a role in enhancing neuroprotective and cognition functions and it can potentially be considered as a neuroprotective compound for therapeutic management of AD in the future. PLOS ONE | https://doi.org/10.1371/journal.pone.0227631 January 16, 2020 1 / 30 OPEN ACCESS Citation: Haider S, Liaquat L, Ahmad S, Batool Z, Siddiqui RA, Tabassum S, et al. (2020) Naringenin protects AlCl 3 /D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress. PLoS ONE 15(1): e0227631.

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Section: Discussionmentioning

confidence: 99%

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

et al. 2020

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“…There is strong evidence that antioxidants play an important role in the neuroprotective mechanisms of memory function (Zaki, Abd‐EL‐Fattah, & Attia, ). The result revealed that combination of both caffeine and caffeic acid administration resulted in a significant ( p < .05) decrease in MDA level with a concomitant synergistic increase in TSH, NPSH, CAT activity, and SOD activity in brain and cerebral cortex of rats compared to either caffeine or caffeic acid alone (Figure a–d).…”

Section: Discussionmentioning

confidence: 99%

The effects of caffeine, caffeic acid, and their combination on acetylcholinesterase, adenosine deaminase and arginase activities linked with brain function

Akomolafe

2017

J Food Biochem

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This study evaluated the effects of caffeine, caffeic acid, and their combination on critical enzymes of brain function. Wistar male rats weighing an average of 205 g were divided into four groups (n = 5) and treated with these compounds for seven successive days. The results of the study revealed that the levels of nitric oxide, total thiol, nonprotein thiol, and acetylcholinesterase activities were increased while the levels of lipid peroxidation, arginase, and adenosine deaminase activities were decreased in animals treated with caffeine when compared to the control. These findings indicate that moderate short‐term consumption of caffeine may be beneficial for brain function. Practical applications The results suggest that moderate short‐term consumption of a combination of caffeine and caffeic acid can effectively improve brain function via improvements in the antioxidant status, decreased lipid peroxidation, and inhibition of acetylcholinesterase, adenosine deaminase, and arginase activities in the brain and cerebral cortex.

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“…However, ACHE inhibitors have limitations, including short half-lives, peripheral cholinergic side effects, and notable hepatotoxicity (Lee et al, 2011). Beside ACH depletion, abnormal phosphorylation of the protein tau, oxidative stress, and altered protein processing resulting in abnormal β-amyloid peptide (Aβ) accumulation are associated with the progressive development of AD, leading to neuronal cell death (Zaki et al, 2014).…”

Section: Effects On Alzheimer's Diseasementioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

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Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

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Naringenin protects against scopolamine-induced dementia in rats

Cited by 66 publications

References 50 publications

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

The effects of caffeine, caffeic acid, and their combination on acetylcholinesterase, adenosine deaminase and arginase activities linked with brain function

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

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